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    GENE:

    SERTAD1 (SERTA Domain Containing 1)

    i
    Other names: SERTAD1, SERTA Domain Containing 1, TRIP-Br1, SEI1, Transcriptional Regulator Interacting With The PHD-Bromodomain 1, SERTA Domain-Containing Protein 1, CDK4-Binding Protein P34SEI1, CDK4-Binding Protein P34SEI, P34(SEI-1), TRIPBR1, SEI-1
    Associations

    News

    Trials
    11ms
    Chemotherapy-Mediated Induction of PD-L1 via SEI1 Facilitates Myeloma Immune Evasion. (PubMed, Adv Sci (Weinh))
    Both in vitro and in vivo experiments demonstrate that treating myeloma cells with PD-L1 antibodies post-chemotherapy significantly enhances the killing efficiency of activated T cells, compared to sequential treatment with chemotherapy and PD-L1 antibodies. This research not only uncovers a pivotal regulatory mechanism of PD-L1 upregulation but also provides a compelling rationale for the integration of chemotherapy and immunotherapy in myeloma treatment.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CREBBP (CREB binding protein) • STING (stimulator of interferon response cGAMP interactor 1) • IRF7 (Interferon Regulatory Factor 7) • PAF1 (PAF1 Homolog, Paf1/RNA Polymerase II Complex Component) • SERTAD1 (SERTA Domain Containing 1)
    almost2years
    Methylated lncRNAs suppress apoptosis of gastric cancer stem cells via the lncRNA-miRNA/protein axis. (PubMed, Cell Mol Biol Lett)
    Our study revealed the requirement for site-specific methylation of lncRNAs in the tumorigenesis of GCSCs, contributing novel insights into cancer development.
    Journal • Cancer stem
    |
    EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) • METTL3 (Methyltransferase Like 3) • MIR22HG (MIR22 Host Gene) • SERTAD1 (SERTA Domain Containing 1) • LRPPRC (Leucine Rich Pentatricopeptide Repeat Containing)
    over3years
    Necroptosis-Related Prognostic Signature and Nomogram Model for Predicting the Overall Survival of Patients with Lung Cancer. (PubMed, Genet Res (Camb))
    Patients in HR group were involved in p53 signaling pathway and cell cycle. This study constructed a robust six-NRDs signature and established a prognostic nomogram for survival prediction of lung cancer.
    Journal • Tumor Mutational Burden
    |
    TMB (Tumor Mutational Burden) • PLK1 (Polo Like Kinase 1) • FLNC (Filamin C) • SERTAD1 (SERTA Domain Containing 1)