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    BIOMARKER:

    SERPINE1 overexpression

    i
    Other names: SERPINE1, Serpin Family E Member 1, PAI, PLANH1, PAI1, Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Endothelial Plasminogen Activator Inhibitor, Plasminogen Activator Inhibitor 1, Serpin E1, PAI-1, Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I
    Entrez ID:
    5054
    Related biomarkers:
    Expression
    4ms
    Expression of Serpin Family E Member 1 (SERPINE1) Is Associated with Poor Prognosis of Gastric Adenocarcinoma. (PubMed, Biomedicines)
    SERPINE1 overexpression is associated with a poor gastric cancer prognosis.
    Journal
    |
    SERPINE1 (Serpin Family E Member 1)
    |
    PAI1 expression • SERPINE1 expression • SERPINE1 overexpression
    8ms
    Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in ccRCC. (PubMed, Front Pharmacol)
    Finally, the high expression of SERPINE1 in ccRCC was verified using qRT-PCR performed on patient samples, six independent GEO cohorts, and proteomic data from the CPTAC database. The findings of the present study revealed that SERPINE1 exhibits aberrant expression in various types of cancers and is associated with cancer immunity and tumor malignancy, providing novel insights for individualized cancer treatment.
    Journal • Tumor mutational burden • IO biomarker • Pan tumor
    |
    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • SERPINE1 (Serpin Family E Member 1)
    |
    PAI1 expression • SERPINE1 expression • SERPINE1 overexpression
    8ms
    Melanoma and subcutaneous adipose tissue: Role of peritumoral adipokines in disease characterization and prognosis. (PubMed, Pigment Cell Melanoma Res)
    Our preliminary study shows that the overexpression of PAI1, LEP, CXCL1, NAMPT, and TNF-α may contribute to the growth and to the local aggressiveness of cutaneous melanoma. It opens the hypothesis of a direct oncogenic role of subcutaneous adipose tissue and adipokines in the tumorigenesis of melanoma.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • NAMPT (Nicotinamide Phosphoribosyltransferase) • CXCL1 (Chemokine (C-X-C motif) ligand 1)
    |
    PAI1 expression • SERPINE1 overexpression
    1year
    SERPINE1 and its co-expressed genes are associated with the progression of clear cell renal cell carcinoma. (PubMed, BMC Urol)
    In this study, we identified hub genes that are strongly related to ccRCC, and highlights the potential utility of overexpressed SERPINE1 and its co-expressed genes could be used as prognostic and diagnostic biomarkers in ccRCC.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • SERPINE1 (Serpin Family E Member 1) • ITGA5 (Integrin Subunit Alpha 5)
    |
    PAI1 expression • SERPINE1 expression • SERPINE1 overexpression