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    BIOMARKER:

    SERPINE1 overexpression

    i
    Other names: SERPINE1, Serpin Family E Member 1, PAI, PLANH1, PAI1, Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Endothelial Plasminogen Activator Inhibitor, Plasminogen Activator Inhibitor 1, Serpin E1, PAI-1, Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1, Plasminogen Activator Inhibitor, Type I
    Entrez ID:
    5054
    Related biomarkers:
    Expression
    2ms
    Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach. (PubMed, Anal Cell Pathol (Amst))
    This study identified vital genes, pathways, and prognostic markers involved in the malignant transformation from normal oral tissue to OPL and primary OSCC, providing insights for early diagnosis and targeted therapy development. Cross-validation with an independent RNA-seq dataset and immunohistochemistry reinforced the findings, supporting the robustness of the identified molecular signatures.
    Journal
    |
    NFIB (Nuclear Factor I B) • SERPINE1 (Serpin Family E Member 1) • ITGA6 (Integrin, alpha 6)
    |
    SERPINE1 expression • SERPINE1 overexpression
    2ms
    HLTF/SERPINE1 Axis Plays a Crucial Pro-oncogenic Role in the Progression from Cervical Precancerous Lesions to Cervical Carcinoma in Vitro. (PubMed, Gynecol Obstet Invest)
    HLTF transcriptionally activates SERPINE1, promoting the progression from cervical precancerous lesions to CC.
    Preclinical • Journal
    |
    SERPINE1 (Serpin Family E Member 1)
    |
    SERPINE1 expression • SERPINE1 overexpression
    6ms
    MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1- extracellular signal-regulated kinase-1/2 axis. (PubMed, World J Gastrointest Oncol)
    This study found that miR-145-5p inhibits tumor progression and is expressed in lower amounts in patients with GC. MiR-145-5p was found to affect GC cell proliferation, migration, and invasion by negatively regulating SERPINE1 levels and controlling the ERK1/2 pathway.
    Journal
    |
    SERPINE1 (Serpin Family E Member 1) • MIR145 (MicroRNA 145)
    |
    PAI1 expression • SERPINE1 expression • SERPINE1 overexpression
    6ms
    PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer. (PubMed, PLoS One)
    In H1993-derived resistant cells, MEK inhibitors could be a potential therapeutic strategy for overcoming resistance with downstream mitogen-activated protein kinase pathway activation. In this study, we revealed the different mechanisms of acquired resistance to the MET inhibitor crizotinib with potential therapeutic application in patients with MET-amplified lung carcinoma.
    Preclinical • Journal
    |
    SERPINE1 (Serpin Family E Member 1)
    |
    MET amplification • SERPINE1 expression • SERPINE1 overexpression
    |
    Xalkori (crizotinib)
    11ms
    Expression of Serpin Family E Member 1 (SERPINE1) Is Associated with Poor Prognosis of Gastric Adenocarcinoma. (PubMed, Biomedicines)
    SERPINE1 overexpression is associated with a poor gastric cancer prognosis.
    Journal
    |
    SERPINE1 (Serpin Family E Member 1)
    |
    PAI1 expression • SERPINE1 expression • SERPINE1 overexpression
    1year
    Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in ccRCC. (PubMed, Front Pharmacol)
    Finally, the high expression of SERPINE1 in ccRCC was verified using qRT-PCR performed on patient samples, six independent GEO cohorts, and proteomic data from the CPTAC database. The findings of the present study revealed that SERPINE1 exhibits aberrant expression in various types of cancers and is associated with cancer immunity and tumor malignancy, providing novel insights for individualized cancer treatment.
    Journal • Tumor mutational burden • IO biomarker • Pan tumor
    |
    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • SERPINE1 (Serpin Family E Member 1)
    |
    PAI1 expression • SERPINE1 expression • SERPINE1 overexpression
    over1year
    Melanoma and subcutaneous adipose tissue: Role of peritumoral adipokines in disease characterization and prognosis. (PubMed, Pigment Cell Melanoma Res)
    Our preliminary study shows that the overexpression of PAI1, LEP, CXCL1, NAMPT, and TNF-α may contribute to the growth and to the local aggressiveness of cutaneous melanoma. It opens the hypothesis of a direct oncogenic role of subcutaneous adipose tissue and adipokines in the tumorigenesis of melanoma.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • NAMPT (Nicotinamide Phosphoribosyltransferase) • CXCL1 (Chemokine (C-X-C motif) ligand 1)
    |
    PAI1 expression • SERPINE1 overexpression
    over1year
    SERPINE1 and its co-expressed genes are associated with the progression of clear cell renal cell carcinoma. (PubMed, BMC Urol)
    In this study, we identified hub genes that are strongly related to ccRCC, and highlights the potential utility of overexpressed SERPINE1 and its co-expressed genes could be used as prognostic and diagnostic biomarkers in ccRCC.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • SERPINE1 (Serpin Family E Member 1) • ITGA5 (Integrin Subunit Alpha 5)
    |
    PAI1 expression • SERPINE1 expression • SERPINE1 overexpression