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    BIOMARKER:

    SERPINB3 mutation

    i
    Other names: SERPINB3, Serpin family B member 3, Serine (or cysteine) proteinase inhibitor, clade B, Squamous cell carcinoma antigen 1, Protein T4-A, Serpin B3
    Entrez ID:
    6317
    over2years
    SerpinB3 drives cancer stem cell survival in glioblastoma (SNO 2021)
    The addition of the cathepsin inhibitor E64D partially rescues the SerpinB3 knockdown, however, SerpinB3 mutants that are unable to inhibit cathepsins fail to do the same. Taken together, our findings, identify a novel GBM CSC-specific survival mechanism involving a previously uninvestigated cysteine protease inhibitor, SerpinB3, and provide a potential target to increase the efficacy of standard of care GBM therapies against therapy-resistant CSCs.
    TGFB1 (Transforming Growth Factor Beta 1) • CTSS (Cathepsin S) • SERPINB3 (Serpin family B member 3)
    |
    MYC expression • SERPINB3 mutation