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    GENE:

    SERPINA5 (Serpin Family A Member 5)

    i
    Other names: SERPINA5, Serpin Family A Member 5, PROCI, PAI3, Protein C Inhibitor, PLANH3, PCI, Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5, Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5, Acrosomal Serine Protease Inhibitor, Plasma Serine Protease Inhibitor, PAI-3, Plasminogen Activator Inhibitor III, Plasminogen Activator Inhibitor-3, Plasminogen Activator Inhibitor 3, Serpin A5, PCI-B
    Associations

    News

    Trials
    8ms
    Cadmium-associated molecular pathways drive gender-specific pathogenesis and prognosis in lung adenocarcinoma. (PubMed, Ecotoxicol Environ Saf)
    We propose a Cd-exposure pathogenesis model wherein disrupted ALB homeostasis triggers aberrant lipid trafficking and SERPINA5-mediated signaling cascades, driving sexual dimorphism in LUAD progression. These findings provide mechanistic insights into environmental carcinogen-induced sex disparities, highlighting ALB and SERPINA5 as potential targets for gender-specific diagnostic strategies and therapeutic development.
    Journal
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    SERPINA5 (Serpin Family A Member 5)
    over1year
    Screening of differential gene expression patterns through survival analysis for diagnosis, prognosis and therapies of clear cell renal cell carcinoma. (PubMed, PLoS One)
    Then we detected 10 repurposable drug molecules (Irinotecan, Imatinib, Telaglenastat, Olaparib, RG-4733, Sorafenib, Sitravatinib, Cabozantinib, Abemaciclib, and Dovitinib.) by molecular docking with KGs-mediated receptor proteins. Their ADME/T analysis and cross-validation with the independent receptors, also supported their potent against ccRCC. Therefore, these outputs might be useful inputs/resources to the wet-lab researchers and clinicians for considering an effective treatment strategy against ccRCC.
    Journal • PARP Biomarker
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • SERPINA5 (Serpin Family A Member 5)
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    Lynparza (olaparib) • sorafenib • imatinib • Verzenio (abemaciclib) • Cabometyx (cabozantinib tablet) • irinotecan • dovitinib (TKI258) • telaglenastat (CB-839) • sitravatinib (MGCD516) • RG4733
    over1year
    Construction and assessment of an angiogenesis-related gene signature for prognosis of head and neck squamous cell carcinoma. (PubMed, Discov Oncol)
    This study established a new prognostic model for AAGs and may guide the selection of therapeutic agents for HNSC. These genes have important functions in the tumor microenvironment; it also provides a valuable resource for the future clinical trials investigating the relationship between HNSC and AAGs.
    Journal • Gene Signature
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    PDGFA (Platelet Derived Growth Factor Subunit A) • SERPINA5 (Serpin Family A Member 5) • STC1 (Stanniocalcin 1)
    over1year
    Integrated analysis of ncRNA in hepatocellular carcinoma with CTNNB1 mutations reveals miR-205-5p and miR-3940-3p Axes. (PubMed, Dig Liver Dis)
    This study demonstrated CTNNB1 mutations associated ncRNA regulatory axes playing different roles in HCC cell proliferation, providing novel insights into the controversial role of CTNNB1 in HCC.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR199A1 (MicroRNA 199a-1) • MIR199A (MicroRNA 199a) • LY6E (Lymphocyte Antigen 6 Family Member E) • MIR205 (MicroRNA 205) • SERPINA5 (Serpin Family A Member 5) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    almost2years
    Comprehensive analysis of T-cell regulatory factors and tumor immune microenvironment in stomach adenocarcinoma. (PubMed, BMC Cancer)
    This study identified T cell-related genes in patients with stomach adenocarcinoma (STAD) for prognosis estimation and proposed potential immunotherapeutic targets for STAD.
    Journal • IO biomarker
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    CXCL12 (C-X-C Motif Chemokine Ligand 12) • CD5 (CD5 Molecule) • SERPINA5 (Serpin Family A Member 5) • ESM1 (Endothelial Cell Specific Molecule 1)
    almost2years
    Evaluating the predictive value of a coagulation-related gene model in glioma. (PubMed, Turk Neurosurg)
    This study established the correlation between the coagulation-related gene model and glioma prognosis, providing deeper insight into the mechanism and treatment of glioma.
    Journal
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    SERPINA5 (Serpin Family A Member 5)
    almost2years
    Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells. (PubMed, Sci Rep)
    Additionally, the protective effects of sericin depended on the counterregulation of APOB, POU2F1, OGT, TRAF6, and HSPA5. These findings suggest that sericin exerts hepatoprotective effects through diverse pathways at different doses, providing novel potential targets for the treatment of liver diseases.
    Journal
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    FGFR1 (Fibroblast growth factor receptor 1) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • STAT1 (Signal Transducer And Activator Of Transcription 1) • APOB (Apolipoprotein B) • CREB1 (CAMP Responsive Element Binding Protein 1) • GATA3 (GATA binding protein 3) • ARID5B (AT-Rich Interaction Domain 5B) • SERPINA5 (Serpin Family A Member 5) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma) • TRAF6 (TNF Receptor Associated Factor 6) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    2years
    PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma. (PubMed, Technol Cancer Res Treat)
    The consensus of multiple parallel computational strategies has unmasked candidate Gleason grade-specific biomarkers. PRADclass, a validated AI model featurizing these biomarkers achieved good performance, and could be trialed to predict the differentiation of prostate cancers. PRADclass is available for academic use at: https://apalania.shinyapps.io/pradclass (online) and https://github.com/apalania/pradclass (command-line interface).
    Journal
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    NCAM1 (Neural cell adhesion molecule 1) • CBX2 (Chromobox 2) • SERPINA5 (Serpin Family A Member 5) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    2years
    Exploration of SERPINA family functions and prognostic value in breast cancer based on transcriptome and in vitro analysis. (PubMed, Environ Toxicol)
    Finally, experimental validation demonstrated that SERPINA5 contributes to lower invasion and metastatic potential of breast cancer cells. With bioinformatics analysis, the significant role SERPINA family genes functioned in breast cancer was comprehensively explored, with SERPINA5 emerging as a key gene in suppressing breast cancer progression.
    Preclinical • Journal
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    SERPINA5 (Serpin Family A Member 5)
    2years
    Predictive multi-omics analysis of BPM31510 in combination with gemcitabine in a phase 2 study of advanced pancreatic ductal adenocarcinoma (PDAC). (ASCO-GI 2024)
    Clinical Trial Registration Number NCT02650804 Sponsored by No funding sources reported Background: Advanced PDAC has limited therapeutic options. Our results point to biomarkers associated with (a) length on trial, (b) outcome and (c) involvement of mitochondrial biology in the mechanism of BPM31510-IV in the adequately treated PDAC population. The data herein supports further study of these biomarkers in late-stage trials to confirm the biological mechanism of BPM31510 in PDAC patients. Clinical trial information: NCT02650804.
    P2 data • Combination therapy • Metastases
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    CRP (C-reactive protein) • SERPINA5 (Serpin Family A Member 5) • LUM (Lumican)
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    gemcitabine • ubidecarenone IV (BPM31510 IV)
    over2years
    A new prognostic model for glioblastoma multiforme based on coagulation-related genes. (PubMed, Transl Cancer Res)
    Moreover, high-risk patients exhibited higher levels of immune cell infiltration, stromal score, immune score, and ESTIMATE score than that of low-risk patients. An analysis of coagulation-related prognostic signatures was conducted in this study, as well as how signature genes may affect GBM progress, providing information that might provide new ideas for the development of GBM-related molecular targeted therapies.
    Journal
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    SERPINA5 (Serpin Family A Member 5)
    over2years
    Identification of angiogenesis-related genes signature for predicting survival and its regulatory network in glioblastoma. (PubMed, Cancer Med)
    Single-cell RNA sequencing also validated malignant cells expressed high levels of the ANXA1, COL6A1, PDPN, and key DETF (WWTR1). Our PDEARG-based risk prediction model and regulatory network identified prognostic biomarkers and provided valuable insight into future studies on angiogenesis in GBM.
    Journal
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    ANXA1 (Annexin A1) • WWTR1 (WW Domain Containing Transcription Regulator 1) • COL6A1 (Collagen Type VI Alpha 1 Chain) • DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3) • NRP1 (Neuropilin 1) • PLK2 (Polo Like Kinase 2) • SLIT2 (Slit Guidance Ligand 2) • HEY1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1) • ITGA5 (Integrin Subunit Alpha 5) • SERPINA5 (Serpin Family A Member 5)