^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    SERPINA3 (Serpin Family A Member 3)

    i
    Other names: SERPINA3, Serpin Family A Member 3, ACT, Alpha-1-Antichymotrypsin, AACT, Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3, Cell Growth-Inhibiting Gene 24/25 Protein, Serpin A3, Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3, Serine (Or Cysteine) Proteinase Inhibitor, Clade A, Member 3, Growth-Inhibiting Protein 24, Growth-Inhibiting Protein 25, Alpha-1 Antichymotrypsin, GIG24, GIG25
    Associations

    News

    Trials
    13d
    Injury-transduced SerpinOLs modulate neuroinflammation and glial activation in the diseased and non-diseased CNS. (PubMed, bioRxiv)
    Together, our findings suggest SerpinOLs are a common population of injury-transduced OLs that amplify neuroinflammation and glial activation in the diseased and non-diseased CNS through SERPINA3N secretion. Our findings provide new insights into myelination-independent role of OLs in regulating CNS pathophysiology.
    Journal
    |
    SERPINA3 (Serpin Family A Member 3)
    15d
    SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing. (PubMed, Cell Rep)
    Targeting SERPINA3 with antisense oligonucleotides successfully sensitized liver cancer cells to irinotecan therapy. These findings elucidate a critical mechanism of chemoresistance in liver cancer and propose targeting SERPINA3 as a promising therapeutic strategy to enhance chemotherapy efficacy.
    Journal
    |
    CTSG (Cathepsin G) • SERPINA3 (Serpin Family A Member 3)
    |
    irinotecan
    1m
    SERPINA3 facilitates malignant progression and remodels tumor immune microenvironment in glioma. (PubMed, Biochem Biophys Rep)
    Intriguingly, within GBM tissues, we further confirmed the expression of SERPINA3 in GAMs, and that SERPINA3 expression is positively associated with CD68 and IBA1 in primary gliomas, indicating remodeling of the tumor immune microenvironment. This study provides an insight into the therapeutic strategy targeting SERPINA3 in glioma patients.
    Journal
    |
    CD68 (CD68 Molecule) • SERPINA3 (Serpin Family A Member 3)
    1m
    SERPINA3 Promotes Glioblastoma Progression by Promoting APOE Expression and Regulating the PI3K/AKT/FOXO1 Pathway. (PubMed, Neurol India)
    SERPINA3 promotes GBM progression by promoting APOE expression and modulating the PI3K/AKT/FOXO1 pathway.
    Journal
    |
    FOXO1 (Forkhead box O1) • APOE (Apolipoprotein E) • SERPINA3 (Serpin Family A Member 3)
    2ms
    Skeletal Muscle Methylome-Transcriptome Disruptions During the Onset and Progression of Colorectal Cancer-Induced Cachexia. (PubMed, Am J Physiol Cell Physiol)
    A conserved feature across -omics layers, sexes, and conditions was dysregulated Runx1 and neurodegeneration-related pathways, which may indicate cachexia-mediated denervation. Overall, we provide evidence for the role of epigenetics in cachexia progression and severity and a valuable resource to the cachexia research communities.
    Journal
    |
    RUNX1 (RUNX Family Transcription Factor 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • OSMR (Oncostatin M Receptor) • SERPINA3 (Serpin Family A Member 3)
    4ms
    Impact of SERPINA3 on the Prognostic Role of KRAS G12R-Mutated Pancreatic Ductal Adenocarcinoma Patients Receiving Gemcitabine-Based Treatment: A Cross-Sectional Study. (PubMed, Health Sci Rep)
    GSEA and TIDE revealed that they were correlated with Cluster of Differentiation 4 Positive T Cell (CD4+ T cell) activation in opposite directions. SERPINA3 overexpression and KRAS G12R were together identified as novel gene signatures to predict poor PFS of PDAC patients receiving gemcitabine-based treatment.
    Observational data • Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • CD4 (CD4 Molecule) • SERPINA3 (Serpin Family A Member 3)
    |
    KRAS mutation • KRAS G12R • KRAS G12
    |
    gemcitabine
    5ms
    Mapping the Proteomic Landscape of Pancreatic Cancer: Prognostic Insights and Subtype Stratification. (PubMed, Cancer Res Commun)
    An 18-protein (PURB, SDCBP2, CD2BP2, GALM, SERPINA3, OAS3, FAN1, ZPR1, KRT2, NUDT2, SMNDC1, SERPINA4, CUTA, WDR36, POSTN, CLEC11A, PEX14, and PI4KA) risk score demonstrated independent prognostic significance for overall survival, and recurrence, and was validated in an independent proteomic dataset generated using a different proteomic technology. This study introduces four novel prognostic PDA subtypes and an 18-protein risk score, validated in an independent dataset, which show promise for improving survival prediction and could serve as a valuable tool for personalized treatment guidance.
    Journal
    |
    HRD (Homologous Recombination Deficiency) • LGALS1 (Galectin 1) • LGALS3 (Galectin 3) • CEACAM6 (CEA Cell Adhesion Molecule 6) • LAMC2 (Laminin subunit gamma 2) • ALDOA (Aldolase Fructose-Bisphosphate A) • CTSD (Cathepsin D) • THBS2 (Thrombospondin 2) • COL12A1 (Collagen Type XII Alpha 1 Chain) • LGALS3BP (Lectin galactoside-binding soluble 3-binding protein) • POSTN (Periostin) • S100P (S100 calcium binding protein P) • SERPINA3 (Serpin Family A Member 3) • ZPR1 (ZPR1 Zinc Finger)
    |
    HRD
    5ms
    A paradigm shift of SERPINA3N in neurobehavioral development and brain injury. (PubMed, bioRxiv)
    Its overexpression promotes neurodegeneration through apoptosis-mediated neuronal loss and disrupts oligodendroglial differentiation and myelination following neonatal brain injury. Collectively, our findings challenge the prevailing paradigm of SERPINA3N in neurodevelopment and injury, revealing that while SERPINA3N is dispensable for neurobehavioral development, it aggravates neural injury and vascular damage under pathological conditions.
    Journal
    |
    SERPINA3 (Serpin Family A Member 3)
    6ms
    Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer. (PubMed, Front Oncol)
    We identified some differentially expressed genes relevant to oncogenic signaling and immunosuppressive tumor-associated macrophages. These findings provide novel insights into factors affecting prognosis in patients with residual disease after NAC for early-stage TNBC.
    Journal
    |
    ACTA2 (Actin Alpha 2 Smooth Muscle) • S100A9 (S100 Calcium Binding Protein A9) • CHI3L1 (Chitinase 3-like 1) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) • KRT14 (Keratin 14) • COL3A1 (Collagen Type III Alpha 1 Chain) • IFI27 (Interferon Alpha Inducible Protein 27) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • MMP7 (Matrix metallopeptidase 7) • MYLK (Myosin Light Chain Kinase) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) • SERPINA3 (Serpin Family A Member 3) • TPM2 (Tropomyosin 2) • RPL22 (Ribosomal Protein L22)
    6ms
    Can Biomarkers Predict Kidney Function Recovery and Mortality in Patients with Critical COVID-19 and Acute Kidney Injury? (PubMed, Diagnostics (Basel))
    This study strongly suggests that uSerpinA3 and uKIM-1 can predict CRR and mortality in patients with critical COVID-19 and AKI requiring KRT. Metabolic analysis appears promising for identifying affected pathways and their clinical impact in this population.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • KIM1 (Kidney injury molecule 1) • LCN2 (Lipocalin-2) • SERPINA3 (Serpin Family A Member 3)
    7ms
    Integrated Omics Approach to Delineate the Mechanisms of Doxorubicin-Induced Cardiotoxicity. (PubMed, bioRxiv)
    Temporal comparison with a delayed timepoint (6 weeks post-DOX) uncovered dynamic remodeling of cardiac signaling, with early response dominated by inflammatory and apoptotic responses, and delayed response marked by cell cycle and DNA repair pathway activation. This integrated-omics study reveals key molecular pathways and temporal changes in DOX-induced cardiotoxicity, identifying potential biomarkers for future cardioprotective strategies.
    Journal
    |
    CD74 (CD74 Molecule) • EPHX1 (Epoxide Hydrolase 1) • NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1) • SERPINA3 (Serpin Family A Member 3)
    |
    doxorubicin hydrochloride
    7ms
    Genomic and Clinical Predictors of Conversion in Initially Unresectable Colorectal Cancer Liver Metastases. (PubMed, Ann Surg Oncol)
    Genomic profiling improves precision management of CRLM, facilitating tailored conversion strategies and better prognostic prediction. Future studies should validate these findings in prospective cohorts to refine personalized treatment for patients with initially unresectable CRLM.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • CEACAM5 (CEA Cell Adhesion Molecule 5) • GRIN2A (Glutamate Ionotropic Receptor NMDA Type Subunit 2A) • CA 19-9 (Cancer antigen 19-9) • SERPINA3 (Serpin Family A Member 3)
    |
    BRAF mutation • HER-2 mutation • ALK mutation