P2, N=12, Recruiting, ConSynance Therapeutics | Not yet recruiting --> Recruiting

P3, N=680, Completed, Otsuka Pharmaceutical Development & Commercialization, Inc. | Active, not recruiting --> Completed

P3, N=315, Completed, Otsuka Pharmaceutical Development & Commercialization, Inc. | Active, not recruiting --> Completed

P1, N=40, Completed, Otsuka Pharmaceutical Development & Commercialization, Inc. | Recruiting --> Completed

P3, N=42, Recruiting, St. Joseph's Healthcare Hamilton | Not yet recruiting --> Recruiting

Moreover, when combined with LPA, amitriptyline curtailed Rho activation and the Rho-mediated cellular responses. (4) These results demonstrate that in astroglial cells, amitriptyline exerts a balanced action on LPA-activated receptors by enhancing the neuroprotective ERK1/2-CREB-BDNF signaling and dampening the potentially detrimental Rho-ROCK pathway, and suggest that this unique property may contribute to the antidepressant activity of the drug.

P1, N=17, Completed, Rutgers, The State University of New Jersey | Recruiting --> Completed | Trial completion date: Dec 2025 --> Sep 2025

P2, N=100, Not yet recruiting, University of Michigan

Imipramine exhibits potent anti-OC activity by inducing apoptosis, inhibiting metastasis, and suppressing EMT, supporting its potential as a repurposed therapeutic agent.

P4, N=30, Completed, Zhongda Hospital, Southeast University; Zhongda Hospital, Southeast University

P=N/A, N=60, Completed, Cairo University

Moreover, AMI suppressed the expression of PD-L1 in cells that had been exposed to or had not been exposed to radiation, whereas radiation enhanced its expression. Because AMI exhibited promising anticancer properties including an interesting, previously unknown immunomodulatory effect, it appears that its potential therapeutic should be verified in an in vivo study.