P4, N=350, Recruiting, Vanderbilt University Medical Center | Trial primary completion date: Jul 2024 --> Jul 2025

P1, N=32, Recruiting, Capital Medical University | Not yet recruiting --> Recruiting

We verify the structure using mutagenesis and confirm that the conformation corresponds to the active state of the receptor. Subsequent study of TrkB interaction with the antidepressant drug fluoxetine, and the antipsychotic drug chlorpromazine, provides a clear self-consistent model, describing the mechanism by which fluoxetine activates the receptor by binding to its transmembrane domain.

P1, N=32, Not yet recruiting, Capital Medical University

Previous studies have shown that chlorpromazine (CPZ) can inhibit YAP1 expression...Collectively, our findings indicate that FOXP3 competitively binds TEAD4 to regulate YAP1 localization in the nucleus and cytoplasm to suppress NPC progression. Consequently, FOXP3 may be a prognostic indicator for HNSCC.

P=N/A, N=338, Suspended, The Affiliated Hospital of Shandong Second Medical University; The Affiliated Hospital of Shandong Second Medical University | Not yet recruiting --> Suspended

P2, N=0, Withdrawn, Clinical Academic Center (2CA-Braga) | N=52 --> 0 | Not yet recruiting --> Withdrawn

P=N/A, N=200, Completed, Central South University | Recruiting --> Completed

Chlorpromazine potentiates the cytotoxic effects of the alkylating agent temozolomide through a mechanism involving downregulation of Cx43 expression and disruption of the cell cycle arrest essential for DNA repair processes. This finding suggests that chlorpromazine may be a potential therapeutic strategy to overcome TMZ resistance in GBM cells by inhibiting their DNA repair mechanisms.

P3, N=0, Withdrawn, Centre Hospitalier St Anne | N=40 --> 0 | Unknown status --> Withdrawn

P2/3, N=11, Active, not recruiting, M.D. Anderson Cancer Center | Enrolling by invitation --> Active, not recruiting | N=150 --> 11

This is one of the few published cases of COVID-19 associated persistent hiccups, occurring more than a month after the initial presentation. Most of the published cases report hiccups occurring in the acute COVID-19 period. Consequently, hiccups occurring in the post-acute COVID-19 period may not be attributable to COVID-19. This case has highlighted the need to consider post-acute COVID-19 in the differential diagnosis of persistent hiccup.

P3, N=367, Completed, Organon and Co | Phase classification: P3b --> P3

Clomipramine showed the best anti-inflammatory effect compared to Escitalopram and Risperidone. Therefore, clomipramine showed the best relieving effect on inflammation of ulcerative colitis in rats.

P4, N=400, Recruiting, The Chaim Sheba Medical Center | Trial completion date: Dec 2022 --> Aug 2024 | Trial primary completion date: Dec 2022 --> Aug 2024

P4, N=26, Completed, Weill Medical College of Cornell University | N=47 --> 26

Taurine and COQ-10 alone notably improved the antioxidant/anti-inflammatory status relative to controls. Among other mechanisms, taurine and COQ-10 abated CPZ-induced hematological deficiencies, via decreased serum levels of oxidative stress, and pro-inflammatory cytokines release, with increased antioxidants and anti-inflammation function.

P4, N=60, Recruiting, All India Institute of Medical Sciences, Bhubaneswar | Not yet recruiting --> Recruiting

Based on our findings, a mechanism of cell death was not able to be established due to lack of cleaved caspase-3 expression. Capable of bypassing many aspects of the lengthy, costly, and difficult cancer drug approval process, chlorpromazine and prazosin deserve further investigation for use in conjunction with traditional chemotherapeutics.

Endocytosis inhibitors identified that Monensin and Chlorpromazine hydrochloride significantly reduced MM-ZC internalization...Overall, the current study provides valuable insights into the cellular uptake and intracellular trafficking of MM-ZC in myeloma cells. Identifying these mechanisms and molecular players involved in MM-ZC uptake contributes to a better understanding of the delivery and potential applications of cell-specific Zip-Codes in gene delivery and drug targeting in cancer research.

P=N/A, N=196, Completed, Northwell Health | Recruiting --> Completed

P4, N=60, Not yet recruiting, All India Institute of Medical Sciences, Bhubaneswar

P=N/A, N=509, Completed, Duke University | Active, not recruiting --> Completed

Mechanistically, the direct binding of JX57 to GRP75 impairs the structure of the mitochondria-associated endoplasmic reticulum membrane and disrupts the endoplasmic reticulum-mitochondrial calcium homeostasis, resulting in a mitochondrial energy crisis and AMP-activated protein kinase activation. Taken together, these findings highlight GRP75 as a potential prognostic biomarker and direct therapeutic target in endometrial cancer and suggest that the chlorpromazine derivative JX57 can potentially be a new therapeutic option for endometrial cancer.

P2, N=5, Completed, University of Rochester | Suspended --> Completed

P1, N=12, Recruiting, Helsinki University Central Hospital

In this phase II clinical trial, we evaluated the addition of chlorpromazine to temozolomide in the adjuvant phase of the standard first-line therapeutic protocol in patients with unmethylated MGMT gene promoter. These findings provide proof-of-concept for the potential of adding CPZ to standard TMZ treatment in GBM patients with unmethylated MGMT gene promoter. https://clinicaltrials.gov/study/NCT04224441, identifier NCT04224441.

The effect of CPZ can be epitomized as an inhibition of the Warburg effect and thus malignancy in GBM cells, while sparing RPE-1 cells. These preclinical data enforce the rationale that allowed us to investigate the role of CPZ in GBM treatment in a recent multicenter Phase II clinical trial.

P1, N=70, Completed, Whanin Pharmaceutical Company | .

P=N/A, N=300, Not yet recruiting, Peking University

6,9). The addition of Chlorpromazine to temozolomide was well tolerated in newly diagnosed Glioblastoma unmethylated patients, with promising impact on outcome measures.

P2/3, N=70, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Jun 2023 --> Jun 2025

P1, N=15, Recruiting, Mohammed Milhem | Trial completion date: Jun 2025 --> Jul 2024 | Trial primary completion date: Jun 2023 --> Jul 2024

For this case, the patient was stable on oral duloxetine, risperidone, and amitriptyline, all of which have been described in the literature to have decreased absorption after bariatric surgery.[1][2] Importantly, while oral risperidone can be easily transitioned to ODT risperidone, the literature suggests that Roux-en-Y Gastric Bypass likely decreases absorption of oral Duloxetine, and this might persist for at least 12 months after surgery.[2] Given the variability of absorption among psychotropics in an altered GI environment, the only current perioperative psychopharmacologic recommendation is to avoid extended-release preparation of medications when possible and maintain psychotropic regimens and closely monitor if a patient is stable on their current regimen. [1]

Patient was symptomatically treated with Risperidone with no significant improvement...Numerous cases have been reported with psychiatric symptoms in the presence of arachnoid cyst, of which, some were reported with significant improvement after surgical decompression. We briefly review and highlight the available literature on the subject, discuss the mechanisms by which cysts can cause neuropsychiatric symptoms, and suggest future studies investigating this association and the role for neurosurgery.

Introduction Olanzapine is combined with aprepitant, palonosetron, and dexamethasone to prevent chemotherapy-induced nausea and vomiting. Grade 2 adverse events were delirium and dizziness in one patient each. Conclusions ME2136 plus standard antiemetic therapy was safe and had a certain efficacy in patients receiving cisplatin-based chemotherapy with or without DM.

Despite current treatment options such as surgery, radiotherapy, and the use of temozolomide and bevacizumab, it is considered incurable...Typical antipsychotics include chlorpromazine, trifluoperazine, and pimozide...Olanzapine and Quetiapine are examples of atypical antipsychotics, a category that was created later...These include NF-B suppression, cyclin deregulation, and -catenin phosphorylation, among others. This review will delve deeper into the polypharmacological, the multiple effects of antipsychotics in the treatment of GBM, and an outlook for the field's future progression.

In this study, the antipsychotic drug chlorpromazine was characterized as an LSD1 inhibitor (IC = 5.135 μM), and a series of chlorpromazine derivatives were synthesized...An in vivo study confirmed that compound 3s can inhibit MFC cell proliferation without significant toxicity in immunocompetent mice. Taken together, our findings indicated that the novel LSD1 inhibitor 3s tethering a phenothiazine scaffold may serve as a lead compound for further development to activate T-cell immunity in gastric cancer.

Screening of common nervous system drugs identified risperidone interaction with TRAF4, and risperidone treatment resulted in the dissociation of TRAF4 and CAV1. Importantly, pharmacological inhibition of TRAF4 with Risperidone potently inhibited self-renewal, abrogated tumorigenicity, and reversed TMZ resistance in GBM. Overall, TRAF4-mediated stabilization of CAV1 promotes stemness and TMZ resistance in GBM, providing a therapeutic strategy that could improve patient outcomes.