The case shows the significance of following prolactin levels in children who are on risperidone therapy particularly those who are non-verbal or those who cannot communicate any discomfort. Clinicians are to remember that risperidone leads to hyperprolactinemia which can simulate pituitary malfunctions. Early identification, educating caregivers, and substitution of prolactin-stimulating drugs with prolactin-sparing ones like olanzapine will allow avoiding unnecessary investigations and enhancing the clinical and family outcomes.

Together, these findings indicate that acute treatment with risperidone in male mice exerts pronounced molecular effects in medial and ventral forebrain regions with high oligodendrocyte and glial cell abundance. Moreover, enrichment analysis points to a molecular convergence between risperidone-induced transcription and genetic pathways implicated in schizophrenia.

P=N/A, N=42, Completed, Hasanuddin University

P4, N=120, Recruiting, Northwell Health | Phase classification: P --> P4

P2, N=128, Recruiting, University of Calgary | Not yet recruiting --> Recruiting

P=N/A, N=104, Not yet recruiting, Eastern Health

P1, N=85, Recruiting, Medical University of Vienna

P2, N=80, Completed, Hasanuddin University

P4, N=180, Recruiting, Northwell Health | Not yet recruiting --> Recruiting

P=N/A, N=80, Completed, Hasanuddin University

In addition, advanced molecular docking analysis demonstrated strong binding affinity of engeletin with the key regulatory proteins SMAD3 (-9.3 kcal/mol) and NF-κB p65 (-9.1 kcal/mol), providing strong evidence that ENG can directly interact with the central regulators of the TGF-β1/Smad and NF-κB signaling pathways. In conclusion, ENG significantly ameliorated RIS-induced hepatotoxicity, highlighting its potential as hepatoprotective adjuvant therapy.

P=N/A, N=50, Completed, Hasanuddin University