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    GENE:

    SEPTIN9 (Septin 9)

    i
    Other names: SEPTIN9, Septin 9, Ov/Br Septin, MLL Septin-Like Fusion Protein MSF-A, Ovarian/Breast Septin, Septin D1, Septin-9, KIAA0991, AF17q25, PNUTL4, SeptD1, SEPT9, MSF1, MSF, MLL Septin-Like Fusion Protein, MLL Septin-Like Fusion, SEPTIN9, SINT1, NAPB
    Associations

    News

    Trials
    7d
    Utilizing an Artificial Intelligence and Machine Learning Model to Predict Colorectal Cancer Risk in American Samoa: A Pilot Study. (PubMed, Asian Pac J Cancer Prev)
    This study demonstrates the potential of AI/ML models for predicting CRC risk in resource-limited and culturally diverse populations like American Samoa. However, significant barriers, including cultural, financial, and logistical factors, limit patient follow-up and the broader implementation of these technologies. Future research should focus on addressing these barriers, enhancing community engagement, and integrating culturally appropriate interventions to improve CRC screening and outcomes in underserved populations.
    Retrospective data • Journal
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    SEPTIN9 (Septin 9)
    7d
    Evaluating plasma and tissue biopsy for DNA methylation markers in early colorectal cancer detection: a systematic review. (PubMed, Asian Biomed (Res Rev News))
    QUADAS-2 illustrated a potential high risk of bias in patient selection and flow/timing domains, which underscores the need for more standardized diagnostic workflows and assay protocols. Future research should focus on multi-marker panels, adherence to regulatory thresholds, cost-effectiveness analyses, and clear clinical management pathways to facilitate the widespread implementation of plasma-based CRC screening.
    Journal
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    SEPTIN9 (Septin 9) • SFMBT2 (Scm Like With Four Mbt Domains 2)
    12d
    Development of a circulating tumor DNA methylation biomarker panel for hepatocellular carcinoma detection. (PubMed, Eur J Surg Oncol)
    These findings suggest that the DNA methylation biomarkers panel could revolutionize HCC diagnostics by enabling earlier, more accurate, and cost-effective detection, particularly in high-risk populations.
    Journal • Circulating tumor DNA
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    SOCS1 (Suppressor Of Cytokine Signaling 1) • SEPTIN9 (Septin 9)
    13d
    SEPT9 methylation as a diagnostic and predictive biomarker in the progression of ductal carcinoma in situ to invasive breast cancer. (PubMed, Sci Rep)
    Additionally, decitabine treatment induced a reduction in SEPT9 methylation levels, which affects microtubule stability, suggesting a potential mechanistic link to tumor invasion. These findings indicate that SEPT9 methylation is a promising biomarker for distinguishing invasive breast cancer from DCIS and for identifying high-risk DCIS lesions with greater potential for progression.
    Journal
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    SEPTIN9 (Septin 9)
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    decitabine
    17d
    Validation of Liquid Biopsy Using a Methylated SEPT9 Assay and Integrated Index for Detecting Hepatocellular Carcinoma. (PubMed, Hepatol Res)
    The diagnostic performance of m-SEPT9 alone could not be fully verified; however, the ASDAm-S9 index demonstrated excellent accuracy for detecting HCC, including its early stages. This index shows promise as a blood-based cancer screening tool for early-stage HCC in the general population.
    Journal • Liquid biopsy
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    AFP (Alpha-fetoprotein) • SEPTIN9 (Septin 9)
    20d
    Y10 phosphorylation of LDHA promotes the release of extracellular vesicle-derived circSEPT9 to enhance the chemoresistance of triple negative breast cancer cells via modulation of miR-515-5p/KIAA1429 axis. (PubMed, Drug Resist Updat)
    Phosphorylated LDHA (Y10) promotes EV-circSEPT9 secretion, elevating intracellular circSEPT9 levels in recipient TNBC cells. By functioning as a competing endogenous RNA (ceRNA) that sponges miR-515-5p, circSEPT9 upregulates KIAA1429, augments m6A methylation, and drives the development of chemoresistance.
    Journal
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    LDHA (Lactate dehydrogenase A) • SEPTIN9 (Septin 9) • VIRMA (Vir Like M6A Methyltransferase Associated)
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    doxorubicin hydrochloride
    22d
    Diagnostic efficacy and subgroup heterogeneity of SHOX2, RASSF1A, Septin9, and HOXA9 methylation in pleural effusion lymphoma. (PubMed, Clin Epigenetics)
    Integrating methylation markers SHOX2, HOXA9, Septin9, and RASSF1A exhibits significant diagnostic potential in pleural effusion lymphoma, especially within DLBCL subgroups. These markers could prove valuable in identifying high-risk subgroups and guiding clinical decision-making.
    Journal • Pleural effusion • IO biomarker
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    TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6) • HOXA9 (Homeobox A9) • RASSF1 (Ras Association Domain Family Member 1) • SEPTIN9 (Septin 9) • SHOX2 (SHOX Homeobox 2)
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    TP53 deletion
    1m
    Prospective Study on the Dynamic Prognostic Prediction of Postoperative Plasma SEPTIN9 Methylation Status in Stage II-III Colorectal Cancer (ChiCTR2500107774)
    P=N/A, N=0, Not yet recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University
    New trial
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    SEPTIN9 (Septin 9)
    2ms
    The value of circulating methylated septin 9 in the diagnosis and prognostic assessment of gastric cancer. (PubMed, Discov Oncol)
    mSEPT9 shows potential in GC diagnosis and prognosis prediction, and its combination with conventional biomarkers may improve the accuracy of GC diagnosis and prognosis assessment.
    Journal
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    CA 19-9 (Cancer antigen 19-9) • SEPTIN9 (Septin 9)
    3ms
    Septin-9 gene methylation and carcinoembryonic antigen as key biomarkers in colorectal cancer: A retrospective study on prognosis and recurrence. (PubMed, Medicine (Baltimore))
    Both mSEPT9 and CEA positivity are independent risk factors for CRC. mSEPT9 is closely linked to tumor burden and distant metastasis, demonstrating higher sensitivity in monitoring postoperative recurrence.
    Retrospective data • Journal
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    CEACAM5 (CEA Cell Adhesion Molecule 5) • SEPTIN9 (Septin 9)
    3ms
    The Role of Epigenetic Biomarkers as Diagnostic, Predictive and Prognostic Factors in Colorectal Cancer. (PubMed, Cancers (Basel))
    Selected lncRNAs, including THOR and LINC01094, have also demonstrated significant prognostic value. Despite these advances, challenges persist, including inconsistent reporting, limited external validation, and a lack of replication by independent research groups.
    Review • Journal
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    ERCC1 (Excision repair cross-complementation group 1) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MIR21 (MicroRNA 21) • GAS6 (Growth arrest specific 6) • MIR211 (MicroRNA 211) • IGFBP3 (Insulin-like growth factor binding protein 3) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • MIR140 (MicroRNA 140) • MIR150 (MicroRNA 150) • MIR215 (MicroRNA 215) • MIR675 (MicroRNA 675) • SDC2 (Syndecan 2) • SEPTIN9 (Septin 9) • SNHG14 (Small Nucleolar RNA Host Gene 14) • ASB16-AS1 (ASB16 Antisense RNA 1)