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    GENE:

    SEPTIN10 (Septin 10)

    i
    Other names: SEPTIN10, Septin 10, SEPT10, Septin-10, FLJ11619, Sept1-Like
    Associations

    News

    Trials
    1year
    Identification of Tumor-Suppressive miR-30a-3p Controlled Genes: ANLN as a Therapeutic Target in Breast Cancer. (PubMed, Noncoding RNA)
    Finally, our assays demonstrated that the overexpression of ANLN had cancer-promoting functions in BC cells. The involvement of miR-30a-3p (the passenger strand) in BC molecular pathogenesis is a new concept in cancer research, and the outcomes of our study strongly indicate the importance of analyzing passenger strands of miRNAs in BC cells.
    Journal
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    EML4 (EMAP Like 4) • BIRC5 (Baculoviral IAP repeat containing 5) • CLTC (Clathrin Heavy Chain) • NCAPG (Non-SMC Condensin I Complex Subunit G) • RIF1 (Replication Timing Regulatory Factor 1) • ANLN (Anillin Actin Binding Protein) • CCNB1 (Cyclin B1) • E2F7 (E2F Transcription Factor 7) • KIF23 (Kinesin Family Member 23) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MIR30A (MicroRNA 30a) • SEPTIN10 (Septin 10) • ZWINT (ZW10 Interacting Kinetochore Protein)
    2years
    SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling. (PubMed, Cancer Lett)
    Importantly, the crosstalk between microfilaments and microtubules is mediated by SEPTIN10 as its loss abrogates actin stress fiber formation after microtubule disruption. Together, the YAP/TAZ target gene SEPTIN10 controls the dynamic interplay between actin and microtubule filaments, which feeds back on Hippo pathway activity in HCC cells and thus acts as molecular switch with impact on oncogenic signaling and cancer cell biology.
    Journal
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    CAPZA2 (Capping Actin Protein Of Muscle Z-Line Subunit Alpha 2) • SEPTIN10 (Septin 10) • TAFAZZIN (Tafazzin)
    over3years
    Septin-6 Regulates Murine and Human Hematopoiesis, and Its Dysregulation Is Associated with Pediatric Myelodysplasia (ASH 2022)
    Engraftment studies demonstrated a significant reduction in bone marrow chimerism in primary transplant recipients after knockdown of Septin-6 most clearly in ST-HSC (Table 2) with a trend towards a decrease in LT-HSC and MPP. These data support a key role of Septin-6 in murine and human hematopoiesis via alterations in cell cycle and validate the pathogenic nature of a specific mutation in human SEPTIN-6.
    Preclinical
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    FLT3 (Fms-related tyrosine kinase 3) • IL6 (Interleukin 6) • CD34 (CD34 molecule) • SEPTIN6 (Septin 6) • SEPTIN10 (Septin 10)