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DRUG:

SENTI-301A

i
Other names: SENTI-301A, SENTI-301, SN301A
Associations
Trials
Company:
Celest Therap, Senti Bio
Drug class:
GPC-3 inhibitor
Associations
Trials
over1year
SENTI-301A, an off-the-shelf multi-armed preclinical CAR-NK cell therapy, for the treatment of GPC3 expressing tumors (AACR 2023)
SENTI-301A is a novel off-the-shelf preclinical CAR-NK cell therapy candidate that targets GPC3-expressing tumors in an antigen-specific manner and exhibits increased persistence via crIL-15. We are exploring the potential synergy between SENTI-301A and CPIs to enhance the existing antitumor functions of SENTI-301A. SENTI-301A is planned for clinical development with an investigational new drug application (IND) expected in 2023.
Preclinical
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IFNG (Interferon, gamma) • GPC3 (Glypican 3) • GZMB (Granzyme B) • IL15 (Interleukin 15)
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GPC3 expression
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SENTI-301A