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DRUG:

senl_BCMA

i
Other names: senl_BCMA, BCMA CAR-T cells, Senl_BCMA03
Associations
Company:
SenlangBio
Drug class:
BCMA-targeted CAR-T immunotherapy
Related drugs:
Associations
1year
High Efficacy and Safety of Nanobody Based Anti-BCMA CAR-T Cell Therapy in Treating Patients with Relapsed or Refractory Multiple Myeloma (ASH 2023)
Methods Autologous peripheral blood lymphocytes were collected from patients, who subsequently underwent intravenous fludarabine (30mg/m2/d) and cyclophosphamide (300mg/m2/d) lymphodepletion chemotherapy from day-5 to day -3. Conclusions The clinical trial demonstrated that BCMA CAR-T therapy, composed of dual nanobody VHHs targeting BCMA (dVHHs), exhibits a high ORR with a manageable safety profile in treating R/R MM patients. This extends even to high-risk patients, such as those with extramedullary lesions, cytogenetics high-risk groups, and patients with plasma cell leukemia or anaplastic plasma cell tumor.
Clinical • CAR T-Cell Therapy • IO biomarker
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TP53 (Tumor protein P53)
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TP53 mutation
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cyclophosphamide • fludarabine IV • senl_BCMA
2years
New trial
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CD8 (cluster of differentiation 8) • IL6 (Interleukin 6) • CD4 (CD4 Molecule) • IL10 (Interleukin 10)
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cyclophosphamide • senl_BCMA