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    GENE:

    SENCR (Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated LncRNA)

    i
    Other names: SENCR, Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated LncRNA, Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated Long Non-Coding RNA, FLI1 Antisense RNA 1 (Non-Protein Coding), FLI1-AS1, FLI1 Antisense RNA 1, NONHSAG010021.2, HSALNG0088110, LncRNA9, SENCR
    Associations

    News

    Trials
    2ms
    The lncRNA SENCR of Polymorphism rs12420823 Drives Breast Cancer Progression and Its Overexpression Regulates this Process via the miR-3648/FOXD3 axis. (PubMed, Arch Biochem Biophys)
    Furthermore, SENCR upregulates FOXD3 mRNA, an effect also abolished by miR-3648. In conclusion, the rs12420823 C allele confers protection against TNBC, and lncRNA SENCR acts as a tumor suppressor by sponging miR-3648 to regulate FOXD3, underscoring its prognostic and therapeutic relevance.
    Journal
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    FOXD3 (Forkhead Box D3) • SENCR (Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated LncRNA)
    almost3years
    Long noncoding RNA SENCR facilitates the progression of acute myeloid leukemia through the miR-4731-5p/IRF2 pathway. (PubMed, Pathol Res Pract)
    Our findings underscore the important role of SENCR in regulating the malignant phenotype of AML cells by targeting the miR-4731-5p/IRF2 axis.
    Journal
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    IRF2 (Interferon Regulatory Factor 2) • MIR4731 (MicroRNA 4731) • SENCR (Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated LncRNA)
    over3years
    Super enhancer-LncRNA SENCR promoted cisplatin resistance and growth of NSCLC through upregulating FLI1. (PubMed, J Clin Lab Anal)
    SE-LncRNA SENCR was upregulated in A549/DDP, which could promote cisplatin resistance and growth of NSCLC cell through upregulating FLI1 expression.
    Journal
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    FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • PCNA (Proliferating cell nuclear antigen) • SENCR (Smooth Muscle And Endothelial Cell Enriched Migration/Differentiation-Associated LncRNA)
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    cisplatin