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    GENE:

    SEMA6A (Semaphorin 6A)

    i
    Other names: SEMA6A, Semaphorin 6A, KIAA1368, SEMA6A1, HT018, SEMAQ, SEMA, Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6A, Semaphorin VIA, Semaphorin-6A, Sema VIa, SEMA6A-1, Semaphorin 6A-1, Semaphorin-6A-1, Sema VIA, VIA
    3ms
    SEMA6A overexpression inhibited tumor growth and metastasis in colorectal cancer. (PubMed, Braz J Med Biol Res)
    In addition, SEMA6A overexpression resulted in a marked decrease in liver metastasis of CRC cells, with decreased numbers of hepatic metastatic nodules and infiltration of cancer cells. In summary, SEMA6A overexpression alleviated CRC progression by inhibiting tumor growth and metastasis both in vivo and in vitro.
    Journal
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    CDH1 (Cadherin 1) • CDH2 (Cadherin 2) • SEMA6A (Semaphorin 6A)
    3ms
    Development and validation of a novel nerve-related prognostic model for gastric cancer based on bulk and single-cell RNA sequencing data. (PubMed, BMC Cancer)
    Taken together, NRRS could serve as a stable and powerful model for survival prediction, and can help to identify GC patients who may benefit from chemotherapy and immunotherapy.
    Journal • IO biomarker
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    NRP1 (Neuropilin 1) • SEMA6A (Semaphorin 6A) • EPHB3 (EPH Receptor B3)
    6ms
    Genome-Wide Identification of Microglia-Related RNA-Binding Proteins and Regulated Alternative Splicing in Spinal Cord Injury. (PubMed, ACS Omega)
    Four RBPs associated with SCI were identified: Nkrf, Marcks, NDRG4, and Ryr2. These key RBPs may serve as potential targets for the treatment of patients with SCI.
    Journal
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    CDC42 (Cell Division Cycle 42) • SEMA6A (Semaphorin 6A) • SEMA6D (Semaphorin 6D) • MARCKS (Myristoylated Alanine Rich Protein Kinase C Substrate) • RTN4 (Reticulon 4) • SEMA4D (Semaphorin 4D)
    7ms
    Identification of Molecular Subtypes of B-Cell Acute Lymphoblastic Leukemia in Mexican Children by Whole-Transcriptome Analysis. (PubMed, Int J Mol Sci)
    Here, we have demonstrated the importance of using RNA-seq to facilitate the differential diagnosis of B-ALL with successful detection of gene fusions and mutations. This will aid both patient risk stratification and precision medicine.
    Journal
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    FLT3 (Fms-related tyrosine kinase 3) • NRAS (Neuroblastoma RAS viral oncogene homolog) • JAK2 (Janus kinase 2) • RUNX1 (RUNX Family Transcription Factor 1) • KMT2A (Lysine Methyltransferase 2A) • ETV6 (ETS Variant Transcription Factor 6) • CRLF2 (Cytokine Receptor Like Factor 2) • NT5C2 (5'-Nucleotidase Cytosolic II) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • TCF3 (Transcription Factor 3) • PBX1 (PBX Homeobox 1) • TYK2 (Tyrosine Kinase 2) • SEMA6A (Semaphorin 6A) • STAT2 (Signal transducer and activator of transcription 2) • DUX4 (Double Homeobox 4) • RAG1 (Recombination Activating 1) • ZNF384 (Zinc Finger Protein 384) • SPATS2L (Spermatogenesis Associated Serine Rich 2 Like)
    7ms
    A ligand-receptor interactome of the bone tumor microenvironment in multiple myeloma bone pain. (PubMed, Pain)
    Together, our analysis maps potential nociceptive signaling pathways of different MM microenvironment cell types. These pathways extend from upstream regulatory kinases to transcription factors to secreted ligands, which can potentially stimulate sensory neuron receptors in the bone.
    Journal
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    IGF1 (Insulin-like growth factor 1) • MIF (Macrophage Migration Inhibitory Factor) • TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) • SEMA6A (Semaphorin 6A) • FGF7 (Fibroblast Growth Factor 7) • MAPK14 (Mitogen-Activated Protein Kinase 14) • NRG2 (Neuregulin 2)
    8ms
    Mechanism of Curcumin Inhibition of Malignant Progression of Lung Cancer Cells by Regulating Ferroptosis via the NRF2/HMOX1 Pathway. (PubMed, Crit Rev Eukaryot Gene Expr)
    Liproxstatin-1 or ML385 treatment reversed curcumin-induced anti-tumor effect and ferroptosis. Curcumin activates the NRF2/HMOX1 pathway to promote ferroptosis, thus repressing the malignant progression of lung cancer cells. These findings provide new insights into the mechanism of curcumin's anti-tumor effect and highlight its potential as a therapeutic drug for lung cancer.
    Journal
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    HMOX1 (Heme Oxygenase 1) • GPX4 (Glutathione Peroxidase 4) • SEMA6A (Semaphorin 6A)
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    liproxstatin-1
    10ms
    Long noncoding RNA semaphorin 6A-antisense RNA 1 reduces hepatocellular carcinoma by promoting semaphorin 6A mRNA degradation. (PubMed, World J Gastroenterol)
    Our findings suggest that SEMA6A-AS1 can inhibit HCC progression through decreasing SEMA6A expression by promoting its mRNA degradation. SEMA6A-AS1 may be a prognostic biomarker and therapeutic target for HCC.
    Journal
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    AFP (Alpha-fetoprotein) • SEMA6A (Semaphorin 6A)
    12ms
    Identification of BCL11A, NTN5, and OGN as Diagnosis Biomarker of Papillary Renal Cell Carcinomas by Bioinformatic Analysis. (PubMed, J Kidney Cancer VHL)
    A combined receiver operating characteristic (ROC) curve analysis revealed that the BCL11A-NTN5-OGN genes, which have specificity and sensitivity values of 0.968 and 0.901, respectively, can be used as a diagnostic biomarker for PRCC. In general, the genes introduced in this study may be used as diagnostic biomarkers for the early diagnosis of PRCC, thus providing the possibility of early treatment and preventing the progression of the disease.
    Journal
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    CCL23 (Chemokine (C-C motif) ligand 23) • SEL1L3 (SEL1L family member 3) • PRCC (Proline Rich Mitotic Checkpoint Control Factor) • SEMA6A (Semaphorin 6A) • BCL11A (BAF Chromatin Remodeling Complex Subunit BCL11A)
    over1year
    m6A- and m5C- modified lncRNAs orchestrate the prognosis in cutaneous melanoma and m6A- modified LINC00893 regulates cutaneous melanoma cell metastasis. (PubMed, Skin Res Technol)
    We made an analysis of m6A- and m5C- related lncRNAs in melanoma samples and a prediction of these lncRNAs' role in prognosis, tumor microenvironment, immune infiltration, and clinicopathological features. We also found that LINC00893, which is potentially regulated by m6A modification, could serve as a tumor-suppressor in melanoma and play an inhibitory role in melanoma metastasis.
    Journal
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    SEMA6A (Semaphorin 6A) • METTL3 (Methyltransferase Like 3) • MIAT (Myocardial Infarction Associated Transcript) • YTHDF3 (YTH N6-Methyladenosine RNA Binding Protein F3)
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    erlotinib • dasatinib • gefitinib • gemcitabine • sorafenib • nilotinib • sirolimus • AZD8055 • AZD6482 • AZD-7762
    over1year
    The intracellular domain of Sema6A is essential for development of the zebrafish retina. (PubMed, J Cell Sci)
    We identified that the intracellular domain is not required for eye size and retinal patterning, however it is required for retinal integrity, the number and end feet strength of Müller glia and protecting against retinal cell death. This novel function for the intracellular domain suggests a role for Sema6A reverse signaling in zebrafish eye development.
    Journal
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    SEMA6A (Semaphorin 6A)
    almost2years
    Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations. (PubMed, Mutagenesis)
    Dedicated studies on 153 DNA repair genes showed associations for some 30 genes, expression of which could be modified by the implicated variants. We finally point out that monitoring of CAs is so far the only method of assessing cancer risk in healthy human populations, and the use of the technology should be made more attractive by developing automated performance steps and incorporating artificial intelligence methods into the scoring.
    Journal
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    PSMA1 (Proteasome 20S Subunit Alpha 1) • SYK (Spleen tyrosine kinase) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • SEMA5A (semaphorin 5A) • SEMA6A (Semaphorin 6A) • UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5) • ITGB3 (Integrin Subunit Beta 3)
    almost2years
    CircSEMA6A upregulates PRRG4 by targeting MiR-520h and recruiting ELAVL1 to affect cell invasion and migration in papillary thyroid carcinoma. (PubMed, Arch Endocrinol Metab)
    CircSEMA6A recruits ELAV1 to stabilize PRRG4 mRNA and drives PTC progression via PRRG4. CircSEMA6A upregulates PRRG4 by targeting miR-520h and recruiting ELAVL1 to affect the invasion and migration of PTC cells, offering insight into the molecular mechanisms of PTC.
    Journal
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    ELAVL1 (ELAV Like RNA Binding Protein 1) • SEMA6A (Semaphorin 6A) • MIR520H (MicroRNA 520h)