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    GENE:

    SELP (Selectin P)

    i
    Other names: SELP, Selectin P, PADGEM, GMP140, CD62P, CD62, PSEL, GRMP, Platelet Activation Dependent Granule-External Membrane Protein, Selectin P (Granule Membrane Protein 140kDa, Antigen CD62), Leukocyte-Endothelial Cell Adhesion Molecule 3, CD62 Antigen-Like Family Member P, Granule Membrane Protein 140kDa, Granule Membrane Protein 140, P-Selectin, GMP-140, LECAM3, Selectin P (Granule Membrane Protein 140kD, Antigen CD62), Platelet Alpha-Granule Membrane Protein, Granulocyte Membrane Protein, CD62P Antigen, Antigen CD62, GMRP
    Associations

    News

    Trials
    5d
    A Clinical Study Evaluating the Safety and Preliminary Efficacy of Universal Allogeneic CAR T-cell Therapy Targeting CD19 and BCMA(QT-019C)in Patients With Refractory Primary Immune Thrombocytopenia (clinicaltrials.gov)
    P1, N=27, Not yet recruiting, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
    New P1 trial
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    SELP (Selectin P)
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    cyclophosphamide
    10d
    Immune and Endothelial-Related Extracellular Vesicles Are Associated with Corticosteroid Response and Mortality in Alcohol-Associated Hepatitis. (PubMed, Int J Mol Sci)
    EVs enriched in platelet (CD49e) and endothelial (CD31) markers were associated with corticosteroid response, whereas EVs enriched with endothelial (CD105 and CD146) and B lymphocyte (CD19) markers were associated with mortality. Overall, EVs enriched in endothelial and monocyte markers may represent a candidate non-invasive tool for predicting corticosteroid response and mortality in AH, aiding risk stratification and early identification of non-responders for timely transplant evaluation.
    Journal • IO biomarker
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    CD20 (Membrane Spanning 4-Domains A1) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL2RA (Interleukin 2 receptor, alpha) • ICAM1 (Intercellular adhesion molecule 1) • CD14 (CD14 Molecule) • MCAM (Melanoma Cell Adhesion Molecule) • CD31 (Platelet and endothelial cell adhesion molecule 1) • CD40 (CD40 Molecule) • ENG (Endoglin) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • VCAM1 (Vascular Cell Adhesion Molecule 1) • ISG20 (Interferon Stimulated Exonuclease Gene 20) • ITGA5 (Integrin Subunit Alpha 5) • SELP (Selectin P)
    20d
    Histological and Immunohistochemical Biomarkers for Wound Age Estimation in Human Skin: A Systematic Review. (PubMed, Cureus)
    No single marker provides sufficient accuracy across all healing phases, highlighting the need for multimodal approaches that combine morphological assessment with panels of temporally complementary biomarkers. Standardization of methods and additional high-quality human studies are essential to improve the reliability and forensic applicability of wound age estimation.
    Review • Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD14 (CD14 Molecule) • CCL2 (Chemokine (C-C motif) ligand 2) • CD68 (CD68 Molecule) • CCL3 (C-C Motif Chemokine Ligand 3) • SELP (Selectin P)
    21d
    Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation. (PubMed, Small)
    Collectively, both SPIONs attenuate complement activation, indicating high biocompatibility. Based on the early immunological responses, DS-SPIONs display a pro-healing immune profile suitable for regenerative drug delivery, whereas HP-SPIONs induce pro-inflammatory responses that may be leveraged for anticancer immunotherapy.
    Journal
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    ICAM1 (Intercellular adhesion molecule 1) • ITGAM (Integrin, alpha M) • SELP (Selectin P)
    1m
    Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC. (PubMed, Front Immunol)
    Despite the small sample size and absence of functional experiments, our results suggest that Pazopanib promotes cytotoxic immune programs but, by six months, reprograms PLT-EVs towards different adhesion characteristics contributing to Treg and MDSC expansion while suppressing NK activity. PLT-EVs may influence the balance between immune activation and suppression during anti-angiogenic therapy, suggesting PLT-EVs as biomarkers and therapeutic targets in mRCC.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • NCAM1 (Neural cell adhesion molecule 1) • ENG (Endoglin) • CD1C (CD1c Molecule) • ITGA2B (Integrin Subunit Alpha 2b) • ITGB1 (Integrin Subunit Beta 1) • SELP (Selectin P)
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    pazopanib
    1m
    Identification of Gastric Cancer Subtypes Based on Neutrophil Extracellular Trap Related Genes. (PubMed, Asia Pac J Clin Oncol)
    NET-related genes are useful for categorizing GC samples into different subtypes and potentially playing significant roles in forecasting prognosis and guiding immunotherapy in GC. Furthermore, the six-gene risk model may aid in personalized prognosis prediction for GC patients.
    Journal • IO biomarker
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    IL6 (Interleukin 6) • BST1 (Bone Marrow Stromal Cell Antigen 1) • SELP (Selectin P) • KCNJ15 (Potassium Inwardly Rectifying Channel Subfamily J Member 15)
    1m
    Genetically programmable protein-biomineral core-shell nanovectors for enhancing tumor microenvironment-activated chemotherapy. (PubMed, Mater Today Bio)
    In vivo assays revealed that S2E3i4Y@CaP-DOX successfully achieved an impressive 4T1 tumor inhibition rate of 75.9 %, much higher than free DOX, without side effects. This core-shell SELP-based platform provides a biocompatible, efficient, and sustainable nanoplatform for tumor-responsive drug delivery, offering a promising strategy for enhanced cancer therapy with spatiotemporal precision.
    Journal
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    SELP (Selectin P)
    1m
    Biomarkers. (PubMed, Alzheimers Dement)
    Our findings demonstrate that EV composition remains stable in Protein Plus BCT compared to EDTA and ACD-A tubes, with a small number of exceptions. This insight into EV stability in blood specimens is crucial for advancing EV biomarker research in neurological disorders, including Alzheimer's disease, potentially enhancing diagnostic accuracy and therapeutic strategies.
    Journal • IO biomarker
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    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • NCAM1 (Neural cell adhesion molecule 1) • CD14 (CD14 Molecule) • CD24 (CD24 Molecule) • CD9 (CD9 Molecule) • ITGB1 (Integrin Subunit Beta 1) • SELP (Selectin P)
    2ms
    Proteomic Validation of MEG-01-Derived Extracellular Vesicles as Representative Models for Megakaryocyte- and Platelet-Derived Extracellular Vesicles. (PubMed, Biomolecules)
    Overall, these findings suggest that MEG-01-derived EVs approximate certain aspects of megakaryocyte-lineage exosomes and activated platelet-like states, although they do not fully replicate native platelet biology. Notably, plasma exosomes show strong proteomic convergence with MEG-01 exosomes, whereas platelet exosomes retain distinct activation-related features.
    Journal
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    RB1 (RB Transcriptional Corepressor 1) • GATA1 (GATA Binding Protein 1) • ITGA2B (Integrin Subunit Alpha 2b) • SELP (Selectin P) • TEAD1 (TEA Domain Transcription Factor 1)
    2ms
    Genetic deletion of P-selectin prevents fibrosis development by inhibiting the neutrophil megakaryocyte emperipolesis in the Gata1low mouse model for myelofibrosis. (PubMed, Eur J Histochem)
    Our data show that emperipolesis is driven by P-sel. Genetic ablation of P-sel rescued the BM microenvironment, by decreasing fibrosis, suggesting that pharmacological targeting of P-sel could contribute to reduce the BM dysfunction and disease progression.
    Preclinical • Journal
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    CXCL8 (Chemokine (C-X-C motif) ligand 8) • TGFB1 (Transforming Growth Factor Beta 1) • SELP (Selectin P)
    2ms
    Tumor-educated-platelets interact with breast cancer-stem-cells via P-selectin-PSGL1 and ensure stemness and metastasis through WNT-β-catenin-VEGF-VEGFR2 intra-cellular signaling: therapeutic modulation by aspirin. (PubMed, Breast Cancer Res)
    These insights into TEP-BCSC interplay, acknowledges TEPs, as-well-as unveils novel receptor-ligand signaling cascade between TEPs and BCSCs, that could be a beneficial therapeutic strategy to target cancer metastasis.
    Journal
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    KDR (Kinase insert domain receptor) • CD24 (CD24 Molecule) • SELP (Selectin P)
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    aspirin
    2ms
    Investigating genetic modifications to enhance L1CAM-CAR T cell migration in solid tumors in a 3D bioprinted neuroblastoma model. (PubMed, Front Immunol)
    The lack of conservation between the human and murine SELPLG proteins likely accounts for the discrepancy between enhanced in vitro migration of SELPLG-deficient L1CAM-CAR T cells and their lack of improved efficacy in the mouse model. This underscores the need for more predictive human-relevant models to better preclinically evaluate CAR T cell function.
    Journal
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    L1CAM (L1 cell adhesion molecule) • SELP (Selectin P)