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    DRUG CLASS:

    Selective serotonin reuptake inhibitor

    Related drugs:
    1d
    PARACHUTES: Pedophilia At Risk Acute Treatment E-therapy vs SSRI (2024-513388-16-00)
    P1/2, N=111, Recruiting, Karolinska University Hospital | Not yet recruiting --> Recruiting
    Enrollment open
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    fluoxetine
    2d
    SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety (clinicaltrials.gov)
    P2, N=240, Recruiting, First Affiliated Hospital of Wenzhou Medical University | Not yet recruiting --> Recruiting
    Enrollment open
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    Opdivo (nivolumab) • Tevimbra (tislelizumab-jsgr) • oxaliplatin • fluoxetine
    8d
    TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children (clinicaltrials.gov)
    P4, N=180, Recruiting, Poznan University of Medical Sciences
    New P4 trial
    |
    fluoxetine
    8d
    Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder (clinicaltrials.gov)
    P=N/A, N=200, Not yet recruiting, Peking University
    New trial
    8d
    Effect of citalopram on chest pain in patients with achalasia. (2024-517701-81-01)
    P4, N=48, Completed, Amsterdam UMC Stichting | Not yet recruiting --> Completed
    Trial completion
    10d
    Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease (clinicaltrials.gov)
    P2, N=58, Completed, University of Michigan | Active, not recruiting --> Completed
    Trial completion
    10d
    Effect of Tongdu Tiaoshen acupuncture on hippocampal neuronal synaptic remodeling in rats with post-stroke depression based on the CCL2-CCR2 pathway (PubMed, Zhongguo Zhen Jiu)
    Forty-eight successfully modeled rats were randomly divided into a model group, an acupuncture group, a fluoxetine group, and an acupuncture+agonist group, with 12 rats in each group...Compared with the acupuncture+agonist group, the acupuncture group showed better improvement in all indexes (P<0.05). Tongdu Tiaoshen acupuncture could improve neurological function and depressive-like behavior in PSD rats, possibly by inhibiting the CCL2-CCR2 pathway and promoting neuronal synaptic remodeling in the hippocampus.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • CCL2 (Chemokine (C-C motif) ligand 2) • CCR2 (C-C Motif Chemokine Receptor 2) • NAPSA (Napsin A Aspartic Peptidase) • SYP (Synaptophysin) • DLG4 (Discs Large MAGUK Scaffold Protein 4)
    |
    fluoxetine
    12d
    Impact of fluoxetine on innate immunity and melanoma metastasis in mice. (PubMed, Adv Med Sci)
    Obtained data confirm the inhibitory effect of fluoxetine on melanoma growth, but only when this antidepressant is given to animals that already struggle with melanoma development. Fluoxetine administration before cancer development accelerates its progress and induces unbeneficial changes in immunity and metalloproteinase levels in comparison to saline-pretreated mice.
    Preclinical • Journal
    |
    MMP9 (Matrix metallopeptidase 9)
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    fluoxetine
    16d
    Melitidin alleviates escitalopram-induced sub-chronic cardiotoxicity via regulating mitochondrial fission-fusion machinery and redox signaling: A biochemical, echocardiographic, and histological study. (PubMed, Tissue Cell)
    Furthermore, in-silico analysis showed strong association of MLD with key regulatory mitochondrial dynamic genes. Our biochemical, radiological, histological, and in-silico findings showed that MLD confers cardio-protection against ETP-induced cardiotoxicity.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • CAT (Catalase) • CRP (C-reactive protein) • MFN2 (Mitofusin 2) • NPPB (Natriuretic Peptide B)
    19d
    Exploring the behavioural and biochemical effects of cordycepin in PTSD-like behaviour using an early life stress mouse model. (PubMed, Biochem Biophys Res Commun)
    Mice exhibiting PTSD-like behaviour were treated with fluoxetine (FLU, 10 mg/kg), an antidepressant drug, and COR (10 and 50 mg/kg). COR demonstrated a dose-dependent response with 50 mg/kg showing consistent improvement in both behavioural and biochemical parameters. Overall, COR exhibited promising activity in this model and may serve as a potential natural therapeutic strategy to investigate for the management of PTSD in clinics.
    Preclinical • Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3)
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    fluoxetine • cordycepin (OVI-123)
    20d
    FUSE: Fluoxetine and Understanding Social Experiences (clinicaltrials.gov)
    P=N/A, N=80, Not yet recruiting, University of Oxford
    New trial
    |
    fluoxetine
    21d
    ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression (clinicaltrials.gov)
    P2, N=162, Recruiting, Stanford University | Not yet recruiting --> Recruiting
    Enrollment open