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    DRUG CLASS:

    Selective serotonin reuptake inhibitor

    Related drugs:
    3d
    Xiao-Yao-San suppresses psychological distress-related colorectal cancer metastasis and enhances antitumor immune responses through regulating gut microbiota-bile acid axis. (PubMed, Phytomedicine)
    XYS prevents psychiatric disorder-associated CRC metastasis and strengthens antitumor immune responses by regulating bsh-expressing gut bacteria and their derived BA profiles. These findings thus offer a novel mechanistic rationale for the potential use of XYS in treating CRC patients with comorbid psychiatric disorders.
    Journal
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    CD8 (cluster of differentiation 8)
    4d
    Sertraline and the Risk of Serious Adverse Events (clinicaltrials.gov)
    P=N/A, N=6893, Completed, London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
    New trial • Adverse events • Serious adverse event
    6d
    Trazodone and the Risk of Serious Adverse Events (clinicaltrials.gov)
    P=N/A, N=31459, Completed, London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
    New trial • Adverse events • Serious adverse event
    9d
    The exploration of the efficacy and possible mechanisms of paroxetine combined with liraglutide in the treatment of depression associated with obesity. (ChiCTR2500113481)
    P=N/A, N=24, Not yet recruiting, Zhongda Hospital Affiliated to Southeast University; Zhongda Hospital Affiliated to Southeast University
    New trial
    9d
    Citalopram treatment window Study Based on PK-PD Model: Correlation analysis of therapeutic drug Monitoring and clinical outcomes in Patients with sleep Disorders and Depression (ChiCTR2500112989)
    P=N/A, N=200, Not yet recruiting, Shanghai General Hospital; Shanghai General Hospital
    New trial
    9d
    Effect of rTMS combined with sertraline on Inflammatory levels and Its correlation in adolescent patients with depression (ChiCTR2500112243)
    P=N/A, N=150, Recruiting, The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University; The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University
    New trial
    9d
    Clinical study of the ability of celecoxib combined with olanzapine and paroxetine hydrochloride to improve depression,anxiety and analgesic effects in patients after hemorrhoidal surgery (ChiCTR2500112052)
    P=N/A, N=60, Completed, Affiliated Hospital of Jining Medical University; Affiliated Hospital of Jining Medical University
    New trial
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    celecoxib oral • olanzapine
    9d
    Study on resting state brain magnetic resonance imaging of DBT combined with drug therapy in adolescents with depression (ChiCTR2600116754)
    P=N/A, N=100, Completed, University City Hospital of Chongqing Medical University; University City Hospital of Chongqing Medical University
    New trial
    9d
    Efficacy and Safety of Idebenone Combined With Escitalopram in Post-stroke Depression: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (ChiCTR2500111442)
    P4, N=216, Not yet recruiting, Xuanwu Hospital Capital Medical University; Xuanwu Hospital Capital Medical University
    New P4 trial
    17d
    ESPRIT: sElective Serotonin reuPtake inhibitoRs In posT-covid (clinicaltrials.gov)
    P3, N=160, Not yet recruiting, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
    New P3 trial
    24d
    Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model. (PubMed, Metab Brain Dis)
    Acupuncture alleviates depression-like behaviors in CUMS-induced rats by modulating microglial polarization and inhibiting neuroinflammation-mediated pyroptosis. Our findings provide further evidence supporting acupuncture as a viable strategy for depression treatment.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • IL1B (Interleukin 1, beta) • IL4 (Interleukin 4) • MRC1 (Mannose Receptor C-Type 1) • NLRP3 (NLR Family Pyrin Domain Containing 3) • CASP1 (Caspase 1)
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    fluoxetine