Furthermore, PSP205 synergistically killed colon cancer cells in combination with proteasome and topoisomerase inhibitors. Cumulatively, our findings suggest that PSP205 targets cancer cells via a novel mechanism, specifically by decreasing the level of COPB2, which has not been extensively studied in the context of cancer therapy development and warrants further investigation.
10 months ago
Journal
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HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) • XBP1 (X-box-binding protein 1) • SEC11C (SEC11 Homolog C)
To sum up, the prognostic model of LUAD constructed based on T-cell-mediated cell killing-related genes was not only capable of screening the prognosis of LUAD patients but was also used for screening those LUAD patients with high sensitivity to immunotherapy. Our study offered novel insights into the clinical treatment and prognostic prediction of LUAD patients.
over 2 years ago
Journal
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CA9 (Carbonic anhydrase 9) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • SEC11C (SEC11 Homolog C)