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GENE:

SEC11C (SEC11 Homolog C)

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Other names: SEC11C, SEC11 Homolog C, Signal Peptidase Complex Subunit, SPCS4C, SPC21, SEC11L3, Signal Peptidase Complex Catalytic Subunit SEC11C, Microsomal Signal Peptidase 21 KDa Subunit, Signal Peptidase Complex 21, SEC11-Like Protein 3, SPase 21 KDa Subunit, SEC11 Homolog C (S. Cerevisiae), SEC11-Like 3 (S. Cerevisiae), SEC11 Homolog C, SEC11-Like 3
Associations
Trials
10ms
PSP205, a Novel Phenyl Sulfonyl Piperidine, Induces Apoptotic Cell Death in Colon Cancer by Modulating Coat Protein Complex-Mediated Vesicle Trafficking. (PubMed, ACS Pharmacol Transl Sci)
Furthermore, PSP205 synergistically killed colon cancer cells in combination with proteasome and topoisomerase inhibitors. Cumulatively, our findings suggest that PSP205 targets cancer cells via a novel mechanism, specifically by decreasing the level of COPB2, which has not been extensively studied in the context of cancer therapy development and warrants further investigation.
Journal
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HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) • XBP1 (X-box-binding protein 1) • SEC11C (SEC11 Homolog C)
over2years
Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma. (PubMed, Autoimmunity)
To sum up, the prognostic model of LUAD constructed based on T-cell-mediated cell killing-related genes was not only capable of screening the prognosis of LUAD patients but was also used for screening those LUAD patients with high sensitivity to immunotherapy. Our study offered novel insights into the clinical treatment and prognostic prediction of LUAD patients.
Journal
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CA9 (Carbonic anhydrase 9) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • SEC11C (SEC11 Homolog C)