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    BIOMARKER:

    SDHB mutation + SDHD mutation

    i
    Other names: SDHB, Succinate Dehydrogenase Complex Iron Sulfur Subunit B, Iron-Sulfur Subunit Of Complex II, Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial, Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip), SDH1, SDH, Succinate Dehydrogenase Complex Subunit B, Iron Sulfur (Ip), Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, SDHIP, CWS2, PGL4, SDH2, Succinate Dehydrogenase Complex Subunit D, CybS, Succinate Dehydrogenase [Ubiquinone] Cytochrome B Small Subunit, Mitochondrial, Succinate-Ubiquinone Oxidoreductase Cytochrome B Small Subunit, Succinate-Ubiquinone Reductase Membrane Anchor Subunit, CII-4, QPs3, SDH4, Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein, Succinate Dehydrogenase Complex Subunit D Integral Membrane Protein, Small Subunit Of Cytochrome B, MC2DN3, CBT1, CWS3, PGL1, SDHD, PGL
    Entrez ID:
    6390; 6392
    Related biomarkers:
    Mutation
    CNA
    Others
    11ms
    Outcomes of systemic treatment according to germline mutational status in patients with metastatic pheochromocytoma and paraganglioma. (PubMed, Clin Genitourin Cancer)
    Our study reveals that CVD and sunitinib are effective treatments for metastatic PPGLs. The results are consistent with previous studies and patients with SDHB and SDHD mutations may benefit most from CVD treatment.
    Clinical • Journal • Metastases
    |
    SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) • SDHD (Succinate Dehydrogenase Complex Subunit D)
    |
    SDHB mutation • SDHB mutation + SDHD mutation
    |
    sunitinib • cyclophosphamide • vincristine • dacarbazine