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    BIOMARKER:

    SDHB deletion

    i
    Other names: SDHB, Succinate Dehydrogenase Complex Iron Sulfur Subunit B, Iron-Sulfur Subunit Of Complex II, Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial, Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip), SDH1, SDH, Succinate Dehydrogenase Complex Subunit B, Iron Sulfur (Ip), Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, SDHIP, CWS2, PGL4, SDH2
    Entrez ID:
    6390
    Related biomarkers:
    Mutation
    Others
    over1year
    Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Imatinib and Adjuvant Therapy Era. (PubMed, Clin Cancer Res)
    We developed a novel, next-generation genomic risk stratification model for primary gastric and small bowel GISTs, complementing traditional clinicopathologic models. Future independent validation of our model in external cohorts is essential.
    Journal • Stroma
    |
    TP53 (Tumor protein P53) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RB1 (RB Transcriptional Corepressor 1) • SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B)
    |
    TP53 mutation • KIT mutation • KIT exon 11 mutation • SDHB deletion
    |
    MSK-IMPACT
    |
    imatinib