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    BIOMARKER:

    SDC1 elevation

    i
    Other names: SDC1, Syndecan 1, Syndecan Proteoglycan 1, CD138 Antigen, Syndecan-1, SYND1, SDC, Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor, Syndecan, CD138
    Entrez ID:
    6382
    Related biomarkers:
    Expression
    2years
    Needle in a Haystack: A Pilot Study Combining Single-Cell Multiomics with Clinical NGS-MRD Sequencing to Search for Circulating Clonotypic Dedifferentiated Myeloma Cells (ASH 2022)
    This profile suggested elevated CD38 expression without elevated CD138 expression, which previously has been associated with dedifferentiated plasma cells and plasmablasts, although further analyses are ongoing. In future studies, we will enrich for B-lymphoid spectrum cells prior to single-cell analytics.
    Clinical • IO biomarker • Next-generation sequencing
    |
    CD19 (CD19 Molecule) • BCL6 (B-cell CLL/lymphoma 6) • PAX5 (Paired Box 5) • SDC1 (Syndecan 1) • CD27 (CD27 Molecule) • HMGB2 (High Mobility Group Box 2) • STMN1 (Stathmin 1)
    |
    CD38 expression • SDC1 elevation
    |
    clonoSEQ
    over2years
    Serum Syndecan-1: A Novel Biomarker for Pancreatic Ductal Adenocarcinoma. (PubMed, Clin Transl Gastroenterol)
    These findings suggest serum SDC1 as a promising novel biomarker for early blood-based diagnosis of pancreatic cancer.
    Journal
    |
    SDC1 (Syndecan 1)
    |
    SDC1 elevation