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    GENE:

    SCNN1A (Sodium Channel Epithelial 1 Subunit Alpha)

    i
    Other names: SCNN1A, Sodium Channel Epithelial 1 Subunit Alpha, Amiloride-Sensitive Sodium Channel Subunit Alpha, ENaCalpha, SCNN1, Sodium Channel, Non Voltage Gated 1 Alpha Subunit, Nonvoltage-Gated Sodium Channel 1 Subunit Alpha, Epithelial Na(+) Channel Subunit Alpha, Alpha-ENaC, Alpha-NaCH, SCNEA, Amiloride-Sensitive Epithelial Sodium Channel Alpha Subunit, Amiloride-Sensitive Sodium Channel Subunit Alpha 2, Nasal Epithelial Sodium Channel Alpha Subunit, Sodium Channel Epithelial 1 Alpha Subunit, Sodium Channel, Non-Voltage-Gated 1 Alpha, Sodium Channel, Nonvoltage-Gated 1 Alpha, Alpha ENaC-2, LIDLS3, BESC2, ENaCa, ENaCA
    Associations

    News

    Trials
    7ms
    Integrative single-cell and exosomal multi-omics uncovers SCNN1A and EFNA1 as non-invasive biomarkers and drivers of ovarian cancer metastasis. (PubMed, Front Immunol)
    By coupling single-cell, bulk tissue, and exosomal transcriptomics, we elucidated the key molecular drivers of OV metastasis and established SCNN1A and EFNA1 as promising non-invasive biomarkers. This multi-omics framework provides an effective strategy for early detection and a better understanding of metastatic progression in OV.
    Journal
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    EFNA1 (Ephrin A1) • SCNN1A (Sodium Channel Epithelial 1 Subunit Alpha)
    10ms
    SCNN1A expression in triple-negative breast cancer: clinical implications for prognosis and neoadjuvant therapy response. (PubMed, World J Surg Oncol)
    SCNN1A overexpression is associated with poor prognosis and non-pCR status in TNBC patients undergoing neoadjuvant chemotherapy.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • SCNN1A (Sodium Channel Epithelial 1 Subunit Alpha)
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    HER-2 expression
    11ms
    Downregulation of the Unfolded Protein Response Links Metformin Treatment to Good Clinical Outcomes in Colorectal Cancer Patients. (PubMed, Curr Oncol)
    We also show that the antiapoptotic protein sFas is downregulated in metformin-treated samples relative to diet-controlled samples (p = 0.005). These findings suggest a role for the unfolded protein response in mediating metformin-related CRC-protective effects by enhancing apoptosis and suggest the investigation of these proteins as targets for novel CRC therapies.
    Clinical data • Journal
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    SCNN1A (Sodium Channel Epithelial 1 Subunit Alpha)
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    metformin
    over1year
    The Association between the JAK-STAT Pathway and Hypertension among Kenyan Women Diagnosed with Breast Cancer. (PubMed, bioRxiv)
    Understanding these mechanisms may help develop targeted treatments that may improve health outcomes of Kenyan women diagnosed with breast cancer. Longitudinal studies with larger cohorts will be needed to validate our results.
    Journal
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    STAT5B (Signal Transducer And Activator Of Transcription 5B) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • SOCS2 (Suppressor Of Cytokine Signaling 2) • SCNN1A (Sodium Channel Epithelial 1 Subunit Alpha) • SMAD9 (SMAD Family Member 9)
    almost2years
    CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p. (PubMed, Genesis)
    CircSCNN1A inhibited RCC cell proliferation, migration and invasion by regulating the miR-590-5p/CLDN8 pathway.
    Journal
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    CCND1 (Cyclin D1) • CDH1 (Cadherin 1) • MMP2 (Matrix metallopeptidase 2) • VIM (Vimentin) • CDH2 (Cadherin 2) • MMP9 (Matrix metallopeptidase 9) • CLDN8 (Claudin 8) • SCNN1A (Sodium Channel Epithelial 1 Subunit Alpha)
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    CCND1 expression • CDH1 expression • VIM expression
    over3years
    CircSCNN1A is a tumor suppressor in renal cell carcinoma via inducing the upregulation of MPP7 by the sponge effect on miR-421. (PubMed, Transpl Immunol)
    The experimental data revealed that circSCNN1A upregulated the expression of MPP7 via sponging miR-421, then inhibiting the progression of RCC.
    Journal
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    SCNN1A (Sodium Channel Epithelial 1 Subunit Alpha)