SCIRT (Stem Cell Inhibitory RNA Transcript)

News alerts, weekly reports and conference planners

1year

M6A -mediated lncRNA SCIRT stability promotes NSCLC progression through binding to SFPQ and activating the PI3K/Akt pathway. (PubMed, Cell Mol Life Sci)

Furthermore, ectopic SCIRT expression upregulated SFPQ and activated the PI3K/Akt pathway following CPT treatment, suggesting an unexpected role of SCIRT in facilitating SFPQ-mediated DSB repair. In brief, our findings highlight the oncogenic role of SCIRT in NSCLC by binding SFPQ and activating PI3K/Akt signaling, presenting a promising therapeutic target for personalized NSCLC treatment.

1 year ago

Journal

HRD (Homologous Recombination Deficiency) • METTL3 (Methyltransferase Like 3) • SCIRT (Stem Cell Inhibitory RNA Transcript)

over3years

The IncRNA SCIRT Promotes the Proliferative, Migratory, and Invasive Properties of Cervical Cancer Cells by Upregulating MMP-2/-9. (PubMed, J Oncol)

Knockdown/overexpressing SCIRT affected CC proliferative/invasive properties. Hence, lncRNA SCIRT is a promising drug-target and a new biological diagnostic molecule for CC patients.

over 3 years ago

Journal

CDH1 (Cadherin 1) • MMP2 (Matrix metallopeptidase 2) • VIM (Vimentin) • CDH2 (Cadherin 2) • MMP9 (Matrix metallopeptidase 9) • SCIRT (Stem Cell Inhibitory RNA Transcript)

CDH1 expression • VIM expression