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DRUG:

SCIB1

i
Other names: SCIB1, ImmunoBody melanoma vaccine, melanoma vaccine TRP2 gp100, SCIB 1, SCIB-1
Associations
Company:
Scancell
Drug class:
gp100 inhibitor, TYRP2 inhibitor
Associations
5ms
TRP-2 / gp100 DNA vaccine and PD-1 checkpoint blockade combination for the treatment of intracranial tumors. (PubMed, Cancer Immunol Immunother)
Here we show that SCIB1, a TRP-2 and gp100 directed ImmunoBody® DNA vaccine, generates a strong TRP-2 specific immune response, as demonstrated by the high number of TRP2-specific IFNγ spots produced and the detection of a significant number of pentamer positive T cells in the spleen of vaccinated mice...Time-to-death was significantly prolonged, and this correlated with increased CD4+ and CD8+ T cell infiltration in the tissue microenvironment (TME). However, in addition to PD-L1 and IDO, the GBM TME was found to contain a significant number of immunoregulatory T (Treg) cell-associated transcripts, and the presence of such cells is likely to significantly affect clinical outcome unless also tackled.
Journal • Checkpoint inhibition • Checkpoint block
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PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • IDO1 (Indoleamine 2,3-dioxygenase 1) • CD4 (CD4 Molecule)
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SCIB1
5ms
Enrollment change • Metastases
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BRAF (B-raf proto-oncogene)
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Keytruda (pembrolizumab) • Opdivo (nivolumab) • Yervoy (ipilimumab) • SCIB1
over2years
SCIB1 in Melanoma Patients Receiving Either Nivolumab With Ipilimumab or Pembrolizumab (The SCOPE Study) (clinicaltrials.gov)
P2, N=87, Recruiting, Scancell Ltd | N=44 --> 87 | Trial completion date: Dec 2023 --> Jan 2026 | Trial primary completion date: Dec 2023 --> Jan 2026
Enrollment change • Trial completion date • Trial primary completion date
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PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene)
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PD-L1 expression • BRAF mutation
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Keytruda (pembrolizumab) • Opdivo (nivolumab) • Yervoy (ipilimumab) • SCIB1
over3years
Clinical • Enrollment change
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PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene)
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PD-L1 expression • BRAF mutation
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SCIB1