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    GENE:

    SAMD5 (Sterile Alpha Motif Domain Containing 5)

    i
    Other names: SAMD5, Sterile Alpha Motif Domain Containing 5, DJ875H10.1, Sterile Alpha Motif Domain-Containing Protein 5, SAM Domain-Containing Protein 5, SAM Domain Containing 1, SAMDC1
    Associations

    News

    Trials
    over1year
    Sterile Alpha Motif Domain-Containing 5 Suppresses Malignant Phenotypes and Tumor Growth in Breast Cancer: Regulation of Polo-Like Kinase 1 and c-Myc Signaling in a Xenograft Model. (PubMed, Cureus)
    This effect appears to be mediated, in part, through its negative association with PLK1. Targeting the SAMD5/PLK1 axis offers a promising therapeutic strategy for addressing aggressive breast cancers.
    Preclinical • Journal
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    CCND1 (Cyclin D1) • CDK4 (Cyclin-dependent kinase 4) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CDK6 (Cyclin-dependent kinase 6) • PLK1 (Polo Like Kinase 1) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • SAMD5 (Sterile Alpha Motif Domain Containing 5)