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Saltikva (attenuated Salmonella typhimurium expressing IL-2)
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Other names: Salmonella-IL2, attenuated Salmonella typhimurium containing the human gene for interleukin-2, MDB401B
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Company:
MD Biosciences, Salspera
Drug class:
IL-2 stimulant
Related drugs:
22d
Saltikva for Metastatic Pancreatic Cancer (clinicaltrials.gov)
P2, N=60, Active, not recruiting, Salspera LLC | Recruiting --> Active, not recruiting
Enrollment closed • Metastases
|
gemcitabine • 5-fluorouracil • albumin-bound paclitaxel • irinotecan • leucovorin calcium • Saltikva (attenuated Salmonella typhimurium expressing IL-2)
1year
Addition of Salmonella-IL2 to FOLFIRINOX for metastatic stage 4 pancreatic cancer nearly doubles median survival (AACR 2023)
Addition of Salmonella-IL2 to FOLFIRINOX for stage 4 metastatic pancreatic cancer results in the near doubling of median survival when compared to historical and site-specific controls receiving FOLFIRNOX only. These findings strongly indicate that a larger pivotal phase 3 multicenter trial is warranted.
Metastases
|
IL2 (Interleukin 2)
|
gemcitabine • 5-fluorouracil • albumin-bound paclitaxel • irinotecan • leucovorin calcium • Saltikva (attenuated Salmonella typhimurium expressing IL-2)
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