Salivary Gland Cancer

SSC in pediatric and young adult patients may demonstrate a broader biological spectrum than traditionally assumed. Although generally considered low grade, a measurable subset of younger patients exhibits recurrent or metastatic behavior, underscoring the importance of systematic outcome assessment in this population.

Herein, we report a case of oncocytic IDC of the parotid gland harboring a STRN::ALK fusion, further expanding the molecular landscape of this tumor. Although this fusion has been previously reported in intercalated duct IDC, to our knowledge, this is the first report of this specific fusion in oncocytic IDC.

Ultimately, the diagnosis of WL-MEC requires high clinical suspicion and the integration of molecular testing to differentiate it from metaplastic Warthin tumors, ensuring appropriate diagnosis and management for this generally indolent but morphologically deceptive neoplasm.

These findings should be interpreted as preliminary and hypothesis-generating. Larger, clinically annotated cohorts with orthogonal validation are required before any diagnostic, prognostic, or clinical relevance of GLUT1 can be considered.

HCCC and CCOC demonstrate clinicopathological similarities and shared EWSR1 rearrangement, supporting a close biological relationship. The considerable overlap between these tumours support the hypothesis that CCOC may represent the intraosseous counterpart of HCCC and highlight the importance of integrated clinicopathological assessment and further clarification in future WHO classifications.

Surgical management yields excellent outcomes, though multifocality may complicate interpretation of recurrence. Larger multi-institutional studies are needed to refine diagnostic criteria and clarify biological behavior.

P1/2, N=120, Not yet recruiting, National Cancer Institute (NCI)

Consistently, decreasing WDR66 expression using CRISPR showed a reduction in tumorsphere formation, lower expression of pluripotency-related genes, decreased cell migration, and increased sensitivity to cisplatin...In this media, we identified several cytokines and growth factors related to inflammation and immune system modulation. In conclusion, WDR66 emerges as a potential biomarker of poor prognosis and a possible predictor of response to immunotherapy, given its impact on cellular pluripotency, treatment resistance and modification of the tumor microenvironment in head and neck cancer.

The false-positive rate was 13.3% in acinic cell carcinoma, histologically similar to secretory carcinoma. Luigi-Oral might be a useful alternative to IHC for screening NTRK fusion-positive rare SGC cases, and advances in digital pathology can facilitate implementation of an AI model in the NTRK screening workflow.

While molecular testing for RUNX2 gene rearrangement or fusion is diagnostically helpful, the RUNX2 IHC is not significantly helpful. Although keratocystoma is benign, recurrence may occur occasionally, warranting close postoperative follow-up.

Warthin-like variant of papillary thyroid carcinoma is a rare thyroid malignancy. Its unique morphology is helpful for diagnosis and differential diagnosis, and its prognosis is relatively good.

Bland cytomorphological features typical of fusion-associated neoplasms do not preclude presence of aggressive histological features and development of recurrence in MSA. These aggressive features may serve as indicators for escalation of treatment, despite the low-grade appearance of MSA.