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    BIOMARKER:

    SAA1-L

    i
    Other names: SAA1, Serum Amyloid A1, Tumor Protein P53 Inducible Protein 4, TP53I4
    Entrez ID:
    6288
    Related biomarkers:
    Expression
    Others
    3years
    SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling. (PubMed, J Cancer)
    Low SAA1 expression segregated glioma patients who were treated with Temozolomide (TMZ) or with high MGMT promoter methylation into survival groups in TCGA and CGGA dataset. Our study strongly suggested that SAA1 was a regulator of cells apoptosis and acted not only as a prognostic marker but also a novel biomarker of sensitivity of glioma to TMZ.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • MGMT (6-O-methylguanine-DNA methyltransferase) • SAA1 (Serum Amyloid A1)
    |
    MGMT promoter methylation • SAA1-L
    |
    temozolomide