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    BIOMARKER:

    S100A8 overexpression

    i
    Other names: S100A8, S100 Calcium Binding Protein A8, Migration Inhibitory Factor-Related Protein 8, Leukocyte L1 Complex Light Chain, Urinary Stone Protein Band A, Calprotectin L1L Subunit, Cystic Fibrosis Antigen, Protein S100-A8, Calgranulin A, CAGA, CFAG, MRP8, S100 Calcium-Binding Protein A8 (Calgranulin A), S100 Calcium-Binding Protein A8, Calgranulin-A, 60B8AG, CP-10, MA387, MRP-8, CGLA, L1Ag, MIF, NIF
    Entrez ID:
    6279
    Related biomarkers:
    Expression
    Others
    over1year
    S100 Calcium-Binding Protein A8 Functions as a Tumor-Promoting Factor in Renal Cell Carcinoma via Activating NF-κB Signaling Pathway. (PubMed, J Invest Surg)
    Overall, S100A8 knockdown restrained RCC malignant biological properties, which was associated with the deactivation of the NF-κB signaling pathway. This present study demonstrates new insights that S100A8 may be a potential therapeutic target in RCC.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • S100A8 (S100 Calcium Binding Protein A8) • MMP9 (Matrix metallopeptidase 9)
    |
    S100A8 overexpression • S100A8 expression
    over1year
    New Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8. (PubMed, Cells)
    HPV (+) OSCC has a peculiar microenvironment pattern distinctive from HPV (-), involving the expression of pathogen-associated pattern receptors, S100A8 overexpression, and NFκB activation and responses, which has important consequences in prognosis and may guide therapeutic decisions.
    Journal
    |
    S100A8 (S100 Calcium Binding Protein A8) • SERPINE1 (Serpin Family E Member 1) • COPS3 (COP9 Signalosome Subunit 3)
    |
    S100A8 overexpression
    over2years
    Evolution of severe (transfusion-dependent) anaemia in myelodysplastic syndromes with 5q deletion is characterized by a macrophage-associated failure of the eythropoietic niche. (PubMed, Br J Haematol)
    Marked Ery-Is loss predicted reduced efficacy (erythrocyte transfusion independence) of lenalidomide therapy (p = 0.0006). Thus, erythroid hypoplasia, a characteristic complication of MDS.del(5q), seems to result primarily from a macrophage-associated failure of the erythropoietic niche markedly reducing the productive capacity of erythropoiesis as the leading factor in anaemia progression and evolution of RBC-TD in MDS.del(5q).
    Journal
    |
    TP53 (Tumor protein P53) • TNFA (Tumor Necrosis Factor-Alpha) • CD34 (CD34 molecule) • S100A8 (S100 Calcium Binding Protein A8) • TFRC
    |
    TP53 mutation • Chr del(5q) • TP53 overexpression • S100A8 overexpression
    |
    lenalidomide
    almost3years
    Effects of S100 calcium-binding protein A8 (S100A8) and S100 calcium-binding protein A9 (S100A9) on matrix metalloproteinase (MMP) expression in nasopharyngeal carcinoma CNE-2 cells. (PubMed, Transl Cancer Res)
    The number of cells in S100A8 overexpression group and S100A9 overexpression group at 24, 48 and 72 h was higher than that in RNAi group, RNAi control group, overexpression control group and normal control group, with statistical significance; The cell doubling time in S100A8 and S100A9 overexpression group was significantly shorter than that in RNAi control group, overexpression control group and normal control group, with statistical significance. High S100A8 and S100A9 expression may promote the expression of MMP7, MMP9 and MMP12, which are related to the invasion and metastasis of NPC cells.
    Journal
    |
    S100A8 (S100 Calcium Binding Protein A8) • S100A9 (S100 Calcium Binding Protein A9) • MMP9 (Matrix metallopeptidase 9) • MMP7 (Matrix metallopeptidase 7)
    |
    S100A8 overexpression • S100A8 expression • S100A9 expression