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    GENE:

    RYR3 (Ryanodine Receptor 3)

    i
    Other names: RYR3, Ryanodine Receptor 3, Brain Ryanodine Receptor-Calcium Release Channel , Brain-Type Ryanodine Receptor, Type 3 Ryanodine Receptor, RYR-3 , RyR3
    Associations

    News

    Trials
    3ms
    Comparing Ovarian Clear Cell Carcinoma and High-Grade Serous Carcinoma Based on the SEER Database and Analyzing the Significantly Mutated Genes. (PubMed, Curr Cancer Drug Targets)
    The independent prognostic factors identified in this study provide a theoretical basis for individualized prognosis judgment in OCCC and HGSC. The SMGs and TMB levels may serve as valuable indicators for prognosis and evaluating targeted therapy or immunother-apy efficacy. Druggable genes such as NOTCH1 and RYR3 offer promising therapeutic tar-gets, while stage-specific pathway enrichments reveal potential intervention strategies. Further validation in larger cohorts is needed to confirm these findings. Our study advances the under-standing of molecular heterogeneity in ovarian cancer and lays the groundwork for personal-ized treatment strategies, ultimately improving patient outcomes.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • NOTCH1 (Notch 1) • MUC19 (Mucin 19, Oligomeric) • TACC2 (Transforming Acidic Coiled-Coil Containing Protein 2) • PCLO (Piccolo Presynaptic Cytomatrix Protein) • RYR3 (Ryanodine Receptor 3)
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    TMB-H
    4ms
    Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression. (PubMed, J Transl Med)
    Overall, this study provides the first evidence that PVT1 establishes a metabolic checkpoint by inducing calcium overload, thereby regulating both the senescence process and functional phenotype of neutrophils, which provides a novel metabolic intervention target for GC immunotherapy.
    Journal • IO biomarker
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    CHEK1 (Checkpoint kinase 1) • SERPINE1 (Serpin Family E Member 1) • PVT1 (Pvt1 Oncogene) • CEACAM8 (CEA Cell Adhesion Molecule 8) • H2AX (H2A.X Variant Histone) • RYR3 (Ryanodine Receptor 3)
    6ms
    Aberrant DNA hypermethylation-regulated long non-coding RNA RYR3-DT affects ferroptosis and progression of glioma cell through the CoQ10/FSP1 axis. (PubMed, Discov Oncol)
    Western blot analysis and RNA sequencing proved that RYR3-DT regulated the ferroptosis CoQ10/FSP1 pathway, concluding that lncRNA RYR3-DT deletion might suppress glioma cell growth migrating and invading ability, and also increase cellular apoptosis via CoQ10/FSP1 pathway. Our research recommends lncRNA RYR3-DT is an expected target for future discoveries on glioma treatment.
    Journal
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    AIFM2 (Apoptosis Inducing Factor Mitochondria Associated 2) • ANXA5 (Annexin A5) • RYR3 (Ryanodine Receptor 3)
    10ms
    Detection of Microsatellite Instability in Endometrial Carcinoma Using a Novel Homopolymer Assay. (PubMed, Int J Surg Pathol)
    Pre-analytic evaluation of the manufacturer's recommended 20% tumor content cut-off is essential to ensure valid results. The Idylla MSI assay offers several advantages over other PCR-based assays including minimal hands-on time, rapid turn-around-time, no requirement for a paired normal sample and the use of FFPE directly without an extraction step.
    Journal • Microsatellite instability • MSi-H Biomarker • IO biomarker
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    MSI (Microsatellite instability) • MRE11A (MRE11 homolog, double strand break repair nuclease) • ACVR2A (Activin A Receptor Type 2A) • BTBD7 (BTB Domain Containing 7) • RYR3 (Ryanodine Receptor 3) • SEC31A (SEC31 Homolog A COPII Coat Complex Component) • SULF2 (Sulfatase 2)
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    MSI-H/dMMR
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    Idylla™ MSI Test
    over1year
    Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance. (PubMed, Hum Genomics)
    The present study identified several putative somatic and germline genetic events with prognostic potential for colorectal cancer that should undergo functional characterization.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • LRP1B (LDL Receptor Related Protein 1B) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • FAT4 (FAT Atypical Cadherin 4) • RYR1 (Ryanodine Receptor 1) • GLI3 (GLI Family Zinc Finger 3) • COL6A3 (Collagen Type VI Alpha 3 Chain) • NAV3 (Neuron Navigator 3 ) • RIF1 (Replication Timing Regulatory Factor 1) • TENM4 (Teneurin Transmembrane Protein 4) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • FLG (Filaggrin) • RYR3 (Ryanodine Receptor 3) • ABCA13 (ATP Binding Cassette Subfamily A Member 13) • TCHH (Trichohyalin)
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    5-fluorouracil
    over1year
    Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma. (PubMed, NPJ Precis Oncol)
    Using The Cancer Genome Atlas (TCGA) cohort (n = 257) and an internal cohort (n = 40), we identify 3 epigenetic markers (GPR15, GNG12, GDNF) and 13 expression markers (IGHA2, SCG5, RPL3L, NTRK1, CD96, BMP6, TFPI2, EFEMP2, RYR3, DMTN, GPD2, BAALC, and FMO3), which are dysregulated in OSCC patients who were never smokers vs. those who have a ≥ 10 pack year history. While mortality risk prediction based on smoking status and clinicopathologic covariates alone is inaccurate (c-statistic = 0.57), the combined epigenetic/expression and histologic signature has a c-statistic = 0.9409 in predicting 5-year mortality in OSCC patients.
    Journal
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    NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • BMP6 (Bone Morphogenetic Protein 6) • BAALC (BAALC Binder Of MAP3K1 And KLF4) • CD96 (CD96 Molecule) • RYR3 (Ryanodine Receptor 3)
    2years
    Function and regulation of miR-186-5p, miR-125b-5p and miR-1260a in chordoma. (PubMed, BMC Cancer)
    miR-186-5p, miR-125b-5p, miR-1260a, and their target protein mRNAs including AMOT, NPTX1, RYR3, P2RX5, TNFSF14 may be the basement of chordoma research.
    Journal
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    MIR186 (MicroRNA 186) • MIR30C • NPTX1 (Neuronal Pentraxin 1) • RYR3 (Ryanodine Receptor 3) • TNFSF14 (TNF Superfamily Member 14)
    2years
    Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction. (PubMed, Brain Res Bull)
    Ryanodine receptor agonist caffeine may improve cognitive dysfunction in mice after isoflurane anesthesia.
    Journal
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    RYR3 (Ryanodine Receptor 3)
    2years
    NBIBLI: Accuracy for Predicting Deep Submucosal Invasion (clinicaltrials.gov)
    P=N/A, N=426, Completed, Althaia Xarxa Assistencial Universitària de Manresa | Recruiting --> Completed | N=1158 --> 426 | Trial completion date: Dec 2021 --> Oct 2022 | Trial primary completion date: Dec 2021 --> Sep 2022
    Trial completion • Enrollment change • Trial completion date • Trial primary completion date
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    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog) • HRAS (Harvey rat sarcoma viral oncogene homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • ARID1A (AT-rich interaction domain 1A) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • KMT2C (Lysine Methyltransferase 2C) • MUC16 (Mucin 16, Cell Surface Associated) • POLD1 (DNA Polymerase Delta 1) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • ARID2 (AT-Rich Interaction Domain 2) • FAT4 (FAT Atypical Cadherin 4) • CSMD1 (CUB And Sushi Multiple Domains 1) • DAPK1 (Death Associated Protein Kinase 1) • SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1) • PCLO (Piccolo Presynaptic Cytomatrix Protein) • RYR3 (Ryanodine Receptor 3) • ZFHX4 (Zinc Finger Homeobox 4)
    2years
    Genomic Alterations as Independent Prognostic Factors to Predict the Type of Lung Cancer Recurrence. (PubMed, Gene)
    Our findings indicate distinct genomic signatures in the LR and DR cohorts, with microtubule disturbance and calcium regulation playing a crucial role in invasiveness in DR of LC. Understanding molecular mechanisms of LC recurrence may lead to the discovery of novel drug targets that could potentially stop spread of cancer cells.
    Journal
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    ABCC9 (ATP Binding Cassette Subfamily C Member 9) • LASP1 (LIM And SH3 Protein 1) • RYR3 (Ryanodine Receptor 3) • STIM1 (Stromal Interaction Molecule 1)
    over2years
    Technical Validation of the Idylla Microsatellite Instability Assay on FFPE Tissue in Colorectal Cancers (AMP Europe 2023)
    The Idylla MSI Test was successfully technically validated as an adequate tool for the evaluation of the MSI status in CRC.
    Microsatellite instability • MSi-H Biomarker
    |
    MSI (Microsatellite instability) • MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • PMS2 (PMS1 protein homolog 2) • MRE11A (MRE11 homolog, double strand break repair nuclease) • ACVR2A (Activin A Receptor Type 2A) • BTBD7 (BTB Domain Containing 7) • RYR3 (Ryanodine Receptor 3) • SEC31A (SEC31 Homolog A COPII Coat Complex Component) • SULF2 (Sulfatase 2)
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    MSI-H/dMMR • PMS2 mutation
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    Idylla™ MSI Test
    over2years
    Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization. (PubMed, Biomedicines)
    Genes encoding autoantigens that share epitopes with AChR-α (NEFM and HSP60), RYR1 (neuronal RYR3), and TTN (NEFM) were up-regulated in thymomas versus hyperplastic and control thymuses, with distinct molecular patterns across the thymoma histotypes that could be relevant for autoimmunity development. Our findings support the idea that altered muscle autoantigen expression, related with hyperplastic and neoplastic changes, may favor autosensitization in the MG thymus, and that molecular mimicry involving tumor-related muscle-like proteins may be a mechanism that makes thymoma prone to developing MG.
    Journal
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    TTN (Titin) • RYR1 (Ryanodine Receptor 1) • HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1) • RYR3 (Ryanodine Receptor 3)