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    GENE:

    RUSC1-AS1 (RUSC1 Antisense RNA 1)

    i
    Other names: RUSC1-AS1, RUSC1 Antisense RNA 1, C1orf104, RUSC1 Antisense RNA 1 (Non-Protein Coding), RUSC1 Antisense Gene Protein 1, FLJ35976, Putative Uncharacterized Protein RUSC1-AS1, Chromosome 1 Open Reading Frame 104, HSALNG0007497, RUSC1-AS1
    Associations

    News

    Trials
    3ms
    Coordinated upregulation of PABPC1L and SNHG lncRNAs defines a tumor-specific expression module in colorectal cancer: evidence from paired tumor-normal expression profiling. (PubMed, Biochem Biophys Rep)
    The combined four-gene model demonstrated moderate discriminatory power, yielding an AUC of 0.76 (95 % CI 0.65-0.86, p < 0.0001) with balanced sensitivity and specificity of 69.8 % each at the 0.5 cutoff (overall accuracy 69.8 %). Taken together, RUSC1-AS1, SNHG17, PABPC1L and SNHG1 can be novel candidates for future diagnostic studies in CRC.
    Journal
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    SNHG1 (Small Nucleolar RNA Host Gene 1) • PABPC1L (Poly(A) Binding Protein Cytoplasmic 1 Like) • SNHG17 (Small Nucleolar RNA Host Gene 17) • RUSC1-AS1 (RUSC1 Antisense RNA 1)
    3ms
    A novel disulfidptosis-related lncRNA signature to predict prognosis and immune response of cervical cancer. (PubMed, Medicine (Baltimore))
    The low-risk group exhibited improved survival outcomes and increased sensitivity to immunotherapy, whereas the high-risk group showed heightened sensitivity to to bexarotene, bicalutamide, embelin, FH535, and pazopanib. Quantitative PCR results indicated that ILF3-DT and PPP1R14B-AS1 were downregulated in CC tissues, whereas RUSC1-AS1 was upregulated. In conclusion, we developed a novel prognostic risk signature based on 9 disulfidptosis-related lncRNAs, which may serve as an independent predictor of immunotherapy response and chemotherapy sensitivity in CC.
    Journal • IO biomarker
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    RUSC1-AS1 (RUSC1 Antisense RNA 1)
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    pazopanib • bicalutamide • Targretin oral (bexarotene oral)
    1year
    Machine learning analysis of CD4+ T cell gene expression in diverse diseases: insights from cancer, metabolic, respiratory, and digestive disorders. (PubMed, Cancer Genet)
    This highlights the distinct roles of these genes in different diseases. Our approach highlights the potential for developing novel therapeutic strategies based on the transcriptional profiles of CD4+ T cells.
    Journal
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    CD4 (CD4 Molecule) • RUSC1-AS1 (RUSC1 Antisense RNA 1)
    over2years
    RUSC1-AS1 promotes the malignant progression of breast cancer depending on the regulation of the miR-326/XRCC5 pathway. (PubMed, Thorac Cancer)
    RUSC1-AS1 could serve as a sponge of miR-326 to promote BC progression by targeting XRCC5, suggesting that RUSC1-AS1 might be a target for BC treatment.
    Journal
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    MIR326 (MicroRNA 326) • RUSC1-AS1 (RUSC1 Antisense RNA 1)