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    GENE:

    RTP4 (Receptor Transporter Protein 4)

    i
    Other names: RTP4, Receptor Transporter Protein 4, Z3CXXC4, IFRG28, 28 KDa Interferon-Responsive Protein, 3CxxC-Type Zinc Finger Protein 4, Receptor-Transporting Protein 4, Zinc Finger, 3CxxC-Type 4, Receptor (Chemosensory) Transporter Protein 4, 28kD Interferon Responsive Protein
    Associations

    News

    Trials
    4ms
    RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8+ T Cell Infiltration and Enhances Immunotherapy Response. (PubMed, J Cell Mol Med)
    Furthermore, RTP4 overexpression markedly improved the efficacy of immune checkpoint blockade therapy. All in all, our findings establish RTP4 as a dual-functional biomarker for prognosis prediction and a potential target to enhance immunotherapy responsiveness in CRC.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • RTP4 (Receptor Transporter Protein 4)
    8ms
    A novel mesothelioma molecular classification based on malignant cell differentiation. (PubMed, Cancer Cell Int)
    The novel molecular classification system and the prognostic prediction model might benefit the management of MESO patients.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • PDZK1IP1 (PDZK1 interacting protein 1) • SERPINH1 (Serpin family H member 1) • ALDH2 (Aldehyde Dehydrogenase 2 Family Member) • SLC7A5 (Solute Carrier Family 7 Member 5) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • RTP4 (Receptor Transporter Protein 4) • CASP1 (Caspase 1)
    over1year
    Identification of RTP4 facilitating ovarian cancer by bioinformatics analysis and experimental validation. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)
    RTP4 was associated with the poor prognosis in OV. In summary, silencing RTP4 inhibited the proliferation, migration, and invasion of OV cells, having the potential to be a novel therapeutic target for OV.
    Journal
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    CD8 (cluster of differentiation 8) • STING (stimulator of interferon response cGAMP interactor 1) • KIFC1 (Kinesin Family Member C1) • TAGLN (Transgelin) • RTP4 (Receptor Transporter Protein 4) • ZFP36 (ZFP36 Ring Finger Protein)
    over1year
    Exploring the impact of GSTM1 as a novel molecular determinant of survival in head and neck cancer patients of African descent. (PubMed, J Exp Clin Cancer Res)
    This study identifies GSTM1 as a novel molecular determinant of survival in HNSCC patients of African descent. It also provides a molecular basis for future research focused on identifying molecular determinants and developing therapeutic interventions to improve outcomes for BAA patients with HNSCC.
    Journal
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    FAT1 (FAT atypical cadherin 1) • PAX5 (Paired Box 5) • GSTM1 (Glutathione S-transferase mu 1) • RTP4 (Receptor Transporter Protein 4)
    over2years
    The diagnostic significance of the ZNF gene family in pancreatic cancer: a bioinformatics and experimental study. (PubMed, Front Genet)
    Moreover, the upregulation of RTP4, SERTAD2, and SP110 were verified by the cell experiments. We established and validated a novel, Zinc finger protein family - related prognostic risk model for patients with PAAD, that has the potential to inform patient management.
    Journal
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    RTP4 (Receptor Transporter Protein 4) • U2AF1L4 (U2 Small Nuclear RNA Auxiliary Factor 1 Like 4)
    almost3years
    RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer. (PubMed, J Gastroenterol)
    We clarified that RTP4 could be silenced by histone H3K9 methylation as the early event of ICB resistance. RTP4 expression could be a promising biomarker for predicting ICB response, and the combination of epigenetic drugs and immune checkpoint inhibitors might exhibit synergistic effects on dMMR/MSI-H CRC.
    Journal • Checkpoint inhibition • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker • Checkpoint block
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    MSI (Microsatellite instability) • RTP4 (Receptor Transporter Protein 4)
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    MSI-H/dMMR
    almost3years
    Identification of the pyroptosis-related gene signature and risk score model for esophageal squamous cell carcinoma. (PubMed, Aging (Albany NY))
    Hence, ESCC patient prognostic outcomes can be assessed by our PRGs-based risk model. Further, these PRGs may also serve as therapeutic targets.
    Journal • Gene Signature
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    CD14 (CD14 Molecule) • RTP4 (Receptor Transporter Protein 4)