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    GENE:

    RTN3 (Reticulon 3)

    i
    Other names: RTN3, Reticulon 3, NSPLII, NSPL2, ASYIP, HAP, Neuroendocrine-Specific Protein-Like 2, Homolog Of ASY Protein, NSP-Like Protein II, RTN3-A1, Neuroendocrine-Specific Protein-Like II, ASY Interacting Protein, NSP-Like Protein 2, Reticulon-3, Isoforme III
    Associations

    News

    Trials
    30d
    Declined RTN3 stabilizes DHCR7 to induce cholesterol-dependent tumor progression and MEK inhibitors insensitivity in thyroid cancer. (PubMed, Cell Death Dis)
    Downregulation of RTN3 lead to stabilization of DHCR7 and elevate cholesterol concentration, activating EGFR/ERK pathway and contributes to progression of thyroid cancer, which can be rescued by HMG-CoA reductase inhibitor Simvastatin. We identified RTN3 as a tumor suppressor and a biomarker of sensitivity to MEK inhibitors and verified the role of cholesterol in drug resistance. The combination of statins provides a novel therapeutic method in patients resistant to MEK inhibitors.
    Journal
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    DHCR7 (7-Dehydrocholesterol Reductase) • RTN3 (Reticulon 3)
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    simvastatin
    over2years
    Machine learning-based integration develops a neutrophil-derived signature for improving outcomes in hepatocellular carcinoma. (PubMed, Front Immunol)
    The developed NDS is a powerful tool for assessing the risk and clinical treatment of HCC. Furthermore, we identified and analyzed the feasibility of the critical gene RTN3 in NDS as a molecular marker for HCC.
    Journal • Machine learning
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    RTN3 (Reticulon 3)