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    GENE:

    RSRC1 (Arginine And Serine Rich Coiled-Coil 1)

    i
    Other names: RSRC1, Arginine And Serine Rich Coiled-Coil 1, SRrp53, BM-011, SFRS21, Arginine/Serine-Rich Coiled-Coil Protein 1, Splicing Factor, Arginine/Serine-Rich 21, Arginine/Serine-Rich Coiled-Coil 1, Serine/Arginine-Related Protein 53, MGC12197, SRRP53, MRT70
    12ms
    Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci. (PubMed, Chin J Cancer Res)
    Our findings validate multiple loci as neuroblastoma risk factors in Chinese children and demonstrate the utility of polygenic risk models, particularly the PRS, in improving risk prediction. These results suggest that integrating multiple genetic variants into a PRS can enhance neuroblastoma risk stratification and potentially improve early diagnosis by guiding targeted screening programs for high-risk children.
    Journal
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    BARD1 (BRCA1 Associated RING Domain 1) • RSRC1 (Arginine And Serine Rich Coiled-Coil 1)
    12ms
    Mendelian randomization analysis of environmental pollution factors and head and neck cancer risk: a causal inference study integrating autophagy-related genes. (PubMed, Discov Oncol)
    This study provides evidence for causal relationships between specific air pollutants and HNSC risk, and identifies potential gene targets for further investigation. The developed clinical prediction model may aid in HNSC prognosis and personalized treatment strategies.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • IRF4 (Interferon regulatory factor 4) • RSRC1 (Arginine And Serine Rich Coiled-Coil 1)