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    GENE:

    RSPO3 (R-Spondin 3)

    i
    Other names: RSPO3, R-Spondin 3, Thrombospondin Type-1 Domain-Containing Protein 2, Thrombospondin, Type I, Domain Containing 2, Protein With TSP Type-1 Repeat, Roof Plate-Specific Spondin-3, R-Spondin-3, PWTSR, THSD2, R-Spondin 3 Homolog (Xenopus Laevis), R-Spondin 3 Homolog
    24d
    Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis. (PubMed, J Pathol)
    These results highlight the importance of evaluating BDTT in SDT, as it may be the main route of hilar extension in aggressive cases.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • ARID1A (AT-rich interaction domain 1A) • NF1 (Neurofibromin 1) • BAP1 (BRCA1 Associated Protein 1) • KMT2D (Lysine Methyltransferase 2D) • MUC1 (Mucin 1) • SMAD4 (SMAD family member 4) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • MUC4 (Mucin 4, Cell Surface Associated) • CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • RSPO3 (R-Spondin 3) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • MUC17 (Mucin 17) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)
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    FGFR2 mutation • FGFR2 fusion • FGFR2 rearrangement
    3ms
    Investigation of the impact of gynoid fat on steatotic and advanced liver diseases-Genomic and clinical perspectives from a large-scale population cohort. (PubMed, Clin Nutr)
    We delineate the genetic landscape of gynoid fat and provide evidence that higher GTFP, proxied by PRS, protects against NAFLD, MASLD and liver fibrosis, supporting adipose-targeted strategies for prevention and risk stratification.
    Journal
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    CCND1 (Cyclin D1) • RSPO3 (R-Spondin 3) • PNPLA3 (Patatin Like Phospholipase Domain Containing 3)
    3ms
    RSPO3 rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics. (PubMed, World J Gastrointest Oncol)
    This study identifies a relatively high incidence of RSPO3 rearrangements in aCRC and a strong association with clinical features. Furthermore, we find that RSPO3 fusions are associated with poorer OS.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR3 (Fibroblast growth factor receptor 3) • CEACAM5 (CEA Cell Adhesion Molecule 5) • RAS (Rat Sarcoma Virus) • RSPO3 (R-Spondin 3) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • RSPO1 (R-Spondin 1)
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    TP53 mutation
    4ms
    Identification and analysis of metabolic reprogramming-related genes in triple-negative breast cancer. (PubMed, Clin Exp Med)
    Our analysis accurately identified four genes-CLEC7A, IRS1, RSPO3, and ALB-that are closely correlated with the metabolic reprogramming characteristics of cancer, and could be regarded as innovative biomarkers for TNBC. This opens a new avenue for further investigation into the mechanisms of metabolic reprogramming in TNBC and new treatment strategies.
    Journal
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    CLEC7A (C-Type Lectin Domain Containing 7A) • RSPO3 (R-Spondin 3)
    5ms
    TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell niche. (PubMed, bioRxiv)
    TNFR1-mediated signaling regulates specification and function of colonic mesenchyme, performing an integral role in the maintenance of the crypt stem cell population.
    Journal
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    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • TNFRSF1A (TNF Receptor Superfamily Member 1A) • RSPO3 (R-Spondin 3) • ITGA6 (Integrin, alpha 6) • RSPO1 (R-Spondin 1)
    6ms
    Circulating proteins and bone mineral density: A Proteome-Wide Mendelian Randomization Study. (PubMed, Curr Med Chem)
    This large-scale Proteome-Wide MR study introduced novel targets for BMD and osteoporosis at transcriptional and translational levels, presenting new prospects for drug repurposing and development.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF9 (TNF Receptor Superfamily Member 9) • LYN (LYN Proto-Oncogene Src Family Tyrosine Kinase) • RSPO3 (R-Spondin 3) • TGFBI (Transforming Growth Factor Beta Induced) • RSPO1 (R-Spondin 1) • TNFRSF19 (TNF Receptor Superfamily Member 19)
    6ms
    Unveiling CTRB2, RSPO3, KLOTB, and ROR1 as obesity-pancreatic disease association proteins: a comprehensive Mendelian randomization study. (PubMed, Gastroenterol Rep (Oxf))
    In mediation analysis, decreased chymotrypsin B2 (CTRB2) levels mediated 1.03% (95% CI [confidence interval] 0.02%-2.03%) of the effects of body mass index on acute pancreatitis...We also found increased klotho beta (KLOTB) levels mediated the effects of waist-hip ratio (7.01%, 95% CI 3.30%-10.71%) and visceral adipose tissue (8.98%, 95% CI 4.55%-13.41%) on chronic pancreatitis, and decreased receptor tyrosine kinase-like orphan receptor 1 (ROR1) levels mediated the effects of body mass index (10.39%, 95% CI 3.36%-17.42%) and visceral adipose tissue (6.29%, 95% CI 1.00%-11.58%) on pancreatic carcinoma. The MR suggests that circulating CTRB2, RSPO3, KLOTB, and ROR1 proteins may mediate associations between obesity and pancreatic diseases.
    Journal
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    ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • KLB (Klotho Beta) • RSPO3 (R-Spondin 3) • RSPO1 (R-Spondin 1)
    7ms
    Exploring hepatic stellate cell-driven fibrosis: therapeutic advances and future perspectives. (PubMed, ADMET DMPK)
    The review highlights critical research gaps in liver fibrosis therapy and promising active targeting strategies and pharmacological interventions to improve therapeutic outcomes. Overall, this review provides a robust foundation for scientists and clinicians to advance active targeting of the disease pathology and to develop new pharmaceutical formulations that are pharmacologically safer and more efficacious.
    Review • Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • RSPO3 (R-Spondin 3) • BSG (Basigin (Ok Blood Group)) • LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4) • TEAD4 (TEA Domain Transcription Factor 4)
    7ms
    Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas. (PubMed, Discov Oncol)
    This study provides evidence and explores the biological significance of BET1L, COL17A1, CFAP43, SH3PXD2A, TTC28, ZNRF3, SLK, AKR1C3, NRXN3, and RSPO3 as potential therapeutic targets for meningiomas, providing new insights into the development of targeted therapy for meningiomas.
    Journal
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    RSPO3 (R-Spondin 3) • COL17A1 (Collagen Type XVII Alpha 1 Chain) • SH3PXD2A (SH3 And PX Domains 2A) • ZNRF3 (Zinc And Ring Finger 3)
    9ms
    Investigation of differentiation conditions for canine duodenum, upper jejunum, and ileum crypt-derived cells for drug transport and metabolism. (PubMed, Drug Metab Dispos)
    The intestinal availability (Fg) of midazolam [0.13 or 0.15 for LLI (BM) and 0.23 or 0.27 for ALI] closely matched the in vivo value (0.15)...SIGNIFICANCE STATEMENT: The study successfully established an in vitro model to investigate drug transport and metabolism in differentiated cells derived from 3D spheroids of the dog duodenum, upper jejunum, and ileum, under both liquid-liquid and air-liquid interface conditions. The platform will be used to address species differences in drug absorption and pre-systemic metabolism between experimental animals and humans although their applicability to cells across other dogs and species needs to be validated in future studies.
    Journal
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    EGF (Epidermal growth factor) • RSPO3 (R-Spondin 3) • RSPO1 (R-Spondin 1)
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    midazolam hydrochloride
    9ms
    Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration. (PubMed, Ann Med)
    Furthermore, RSPO3 exhibited a positive correlation with tumour progression, the proportion of plasma cells and M2 macrophages in mice, while showing a negative association with M1 macrophages. The present study identified ECM1, NPC1L1 and RSPO3 as new diagnostic biomarkers for HCC based on normal and diseased samples from HCC, meanwhile the pro-oncogenic function of RSPO3 and its regulation on immune infiltration have been confirmed.
    Journal
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    SDC1 (Syndecan 1) • MRC1 (Mannose Receptor C-Type 1) • RSPO3 (R-Spondin 3) • RSPO1 (R-Spondin 1)
    9ms
    Protein interaction network drive more group integrated analytic larynx hub protein markers: LYVE1/FBLN5/INMT/DCN/ZFY/RSPO3 protein macromolecule collaborative diagnosis of a new era. (PubMed, Int J Biol Macromol)
    In particular, the ME2 module, as a central hub of tumorigenesis, emphasizes the importance of LYVE1, FBLN5, INMT, DCN, ZFY, and RSPO3 in the tumor network by coordinating the co-expression network. LYVE1, FBLN5, INMT, DCN, ZFY, and RSPO3 have potential biomarker value as central proteins that could be used in the future for the diagnosis and development of treatment strategies for laryngeal cancer.
    Journal
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    RSPO3 (R-Spondin 3) • LYVE1 (Lymphatic vessel endothelial hyaluronan receptor 1)