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    BIOMARKER:

    RSPO2 rs555008

    i
    Other names: RSPO2, R-Spondin 2, Roof Plate-Specific Spondin-2, R-Spondin-2, R-Spondin 2 Homolog (Xenopus Laevis), R-Spondin 2 Homolog, CRISTIN2, TETAMS2, HRspo2
    Entrez ID:
    340419
    over5years
    A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: data from FIRE-3 and TRIBE trials. (PubMed, Eur J Cancer)
    Genotyping of the RSPO2 rs555008 polymorphism may help to select patients who will derive the most benefit from FOLFIRI/bevacizumab dependent on (K)RAS mutational status.
    Clinical • Journal
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    KRAS (KRAS proto-oncogene GTPase) • RSPO2 (R-Spondin 2)
    |
    KRAS mutation • RSPO2 rs555008
    |
    Avastin (bevacizumab) • Erbitux (cetuximab)