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    BIOMARKER:

    RSF1 amplification

    i
    Other names: RSF1, Remodeling And spacing factor 1, P325 Subunit Of RSF Chromatin-Remodeling Complex, Hepatitis B Virus X-Associated Protein, HBV PX-Associated Protein 8, XAP8, Hepatitis B Virus X Associated Protein, RSF-1, P325
    Entrez ID:
    51773
    almost2years
    The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer. (PubMed, Int J Mol Sci)
    Most notably, ARID1A in endometriosis-related OC, SMARCA4, and SMARCB1 in hypercalcemic type small cell ovarian carcinoma (SCCOHT), ACTL6A, CHRAC1, RSF1 amplification in high-grade serous OC. Here we review the available literature on CRCs' involvement in OC to improve our understanding of its development and investigate CRCs as possible biomarkers and treatment targets for OC.
    Review • Journal
    |
    ARID1A (AT-rich interaction domain 1A) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • RSF1 (Remodeling and spacing factor 1)
    |
    ARID1A mutation • RSF1 amplification
    almost4years
    RSF1 requires CEBP/β and hSNF2H to promote IL-1β-mediated angiogenesis: the clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas. (PubMed, Angiogenesis)
    In vivo, both RSF1 knockdown and anti-IL-1β P2D7KK (200 μg twice weekly) enabled significant growth inhibition and devascularization in xenografts. In conclusion, RSF1 overexpression, partly attributable to RSF1 amplification, contributes a novel proangiogenic function by partnering with CEBP/β to cotransactivate IL1B, highlighting its prognostic, pathogenetic, and therapeutic relevance in myxofibrosarcomas.
    Clinical • Journal
    |
    CEBPA (CCAAT Enhancer Binding Protein Alpha) • IL1B (Interleukin 1, beta) • RSF1 (Remodeling and spacing factor 1)
    |
    RSF1 amplification