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    BIOMARKER:

    RRM1 deletion

    i
    Other names: Ribonucleotide Reductase Catalytic Subunit M1, Ribonucleoside-Diphosphate Reductase Large Subunit, Ribonucleoside-Diphosphate Reductase Subunit M1, Ribonucleotide Reductase M1 Polypeptide, RR1, Ribonucleotide Reductase Large Subunit, Ribonucleotide Reductase R1 Subunit, RIR1, rrm1
    Entrez ID:
    6240
    Related biomarkers:
    Expression
    8ms
    A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-β Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma Cells. (PubMed, Int J Mol Sci)
    Notably, primary and metastatic samples from renal cancer patients exhibited high A1CF expression, low p65(Ser536) phosphorylation, and decreased IFN-β levels in renal carcinoma tissues compared with the corresponding paracancerous tissues. Our results indicate that A1CF-decreased p65(Ser536) phosphorylation and IFN-β levels may be caused by A1CF competitive binding to the p65-combined site on NKRF and demonstrate the direct binding of A1CF independent of RNA or DNA in signal pathway regulation and tumor promotion in renal carcinoma cells.
    Journal
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    RRM1 (Ribonucleotide Reductase Catalytic Subunit M1) • APOBEC1 (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 1) • IFNB1 (Interferon Beta 1) • RELA (RELA Proto-Oncogene)
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    RRM1 deletion • RELA expression