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    GENE:

    RRAGC (Ras Related GTP Binding C)

    i
    Other names: RRAGC, Ras Related GTP Binding C, GTR2, Ras-Related GTP-Binding Protein C, GTPase-Interacting Protein 2, FLJ13311, TIB929, Ras-Related GTP Binding C, Rag C Protein, Rag C, RAGC, RagC
    Associations

    News

    Trials
    over2years
    Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphoma. (PubMed, BMC Complement Med Ther)
    Cardamonin exerts selective therapeutic effects on RagC-mutant cells. Cardamonin can serve as a drug for individualised therapy for follicular lymphoma with RRAGC mutations.
    Journal
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    RRAGC (Ras Related GTP Binding C)
    |
    MTOR mutation
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    sirolimus
    over2years
    De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood. (PubMed, Genet Med)
    The above results are in line with a constitutive overactivation of the mTORC1 pathway. Our study establishes de novo missense variants in RRAGC as cause of an early-onset mTORopathy with unfavorable prognosis.
    Journal
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    RPS6 (Ribosomal Protein S6) • TFEB (Transcription Factor EB 2) • RRAGC (Ras Related GTP Binding C) • RRAGD (Ras related GTP binding)
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    sirolimus