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    GENE:

    RPTOR (Regulatory Associated Protein Of MTOR Complex 1)

    i
    Other names: RPTOR, Regulatory Associated Protein Of MTOR Complex 1, Raptor, KIAA1303, KOG1, Mip1, Regulatory-Associated Protein Of MTOR, P150 Target Of Rapamycin (TOR)-Scaffold Protein Containing WD-Repeats, Regulatory Associated Protein Of MTOR, Complex 1, P150 Target Of Rapamycin (TOR)-Scaffold Protein, Regulatory Associated Protein Of MTOR, RAPTOR
    7d
    Hyperactivation of mTORC1 signaling mediates folliculin deficiency-induced pulmonary cyst formation in Birt-Hogg-Dubé syndrome. (PubMed, J Clin Invest)
    Attenuation of mTORC1 activity by knocking out Raptor gene (Rptor) or pharmacologic inhibition using rapamycin substantially rescued the pulmonary pathology caused by Flcn deletion in mice. Taken together, these human and mouse data support a model in which mTORC1 hyperactivation drives pulmonary cystic pathology in BHD.
    Journal
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    FLCN (Folliculin) • RPTOR (Regulatory Associated Protein Of MTOR Complex 1)
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    sirolimus
    2years
    RPTOR mutation: a novel predictor of efficacious immunotherapy in melanoma. (PubMed, Invest New Drugs)
    RPTOR-Mut melanoma patients had higher expression levels of immune-related genes than the RPTOR-WT patients. Our results suggest that RPTOR mutation could serve as a predictor of effective immunotherapy for melanoma.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • CD4 (CD4 Molecule) • RPTOR (Regulatory Associated Protein Of MTOR Complex 1)
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    TMB-H • RPTOR mutation
    2years
    MALAT1 DEREPRESSES MIR-433-3P-MEDIATED RPTOR SUPPRESSION TO IMPAIR AUTOPHAGY AND DRIVE PYROPTOSIS IN ENDOTOXEMIA. (PubMed, Shock)
    MALAT1 is highly expressed in endotoxemia. MALAT1 promotes RPTOR expression by competitively absorbing miR-433-3p, inhibits LPS-activated HUVEC cell autophagy, promotes cell death, enhances LPS-induced inflammatory activation of vascular endothelial cells, and ultimately promotes the progression of endotoxemia.
    Journal
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    mTOR (Mechanistic target of rapamycin kinase) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • RPTOR (Regulatory Associated Protein Of MTOR Complex 1) • MIR433 (MicroRNA 433)
    over2years
    Cancer-Associated Fibroblasts Influence Survival in Pleural Mesothelioma: Digital Gene Expression Analysis and Supervised Machine Learning Model. (PubMed, Int J Mol Sci)
    CIT revealed a three-tier system based on FAP, NF1, and RPTOR expressions. We could outline the prognostic value of CAFs-induced PI3K signaling pathway activation together with FAP-dependent CDK4 mediated cell cycle progression in PM, where prognostic and predictive biomarkers are urgently needed to introduce new therapeutic strategies.
    Journal • Machine learning
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    NF1 (Neurofibromin 1) • KDR (Kinase insert domain receptor) • CDK4 (Cyclin-dependent kinase 4) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • VEGFC (Vascular Endothelial Growth Factor C) • FAP (Fibroblast activation protein, alpha) • PKMYT1 (Protein Kinase Membrane Associated Tyrosine/Threonine 1) • RPTOR (Regulatory Associated Protein Of MTOR Complex 1)