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    BIOMARKER:

    RPS6KB1 amplification

    i
    Other names: RPS6KB1, Ribosomal Protein S6 Kinase B1, S6K1, Serine/Threonine-Protein Kinase 14A, Ribosomal Protein S6 Kinase Beta-1, Ribosomal Protein S6 Kinase I, P70(S6K)-Alpha, S6K-Beta-1, P70 S6KA, STK14A, PS6K, S6K, Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1, Ribosomal Protein S6 Kinase, 70kD, Polypeptide 1, 70 KDa Ribosomal Protein S6 Kinase 1, Serine/Threonine Kinase 14 Alpha, P70 Ribosomal S6 Kinase Alpha, P70 S6 Kinase, Alpha, P70 S6 Kinase Alpha, P70 S6K-Alpha, P70-Alpha, P70-S6K 1, P70-S6K,
    Entrez ID:
    6198
    Related biomarkers:
    Expression
    Others
    2years
    S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair. (PubMed, Elife)
    Moreover, breast cancer cells harboring RPS6KB1 gene amplification show increased resistance to several DNA damaging agents and S6K1 expression is associated with poor survival of breast cancer patients treated with chemotherapy. Our findings reveal an unexpected function of S6K1 in the DNA repair pathway, serving as a tumorigenic barrier by safeguarding genomic stability.
    Journal
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    MSH6 (MutS homolog 6) • RPS6KB1 (Ribosomal Protein S6 Kinase B1) • CDK1 (Cyclin-dependent kinase 1)
    |
    RPS6KB1 amplification