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    BIOMARKER:

    RPS6 overexpression

    i
    Other names: RPS6, S6, Ribosomal Protein S6, 40S Ribosomal Protein S6, Phosphoprotein NP33, Small Ribosomal Subunit Protein ES6
    Entrez ID:
    6194
    Related biomarkers:
    Expression
    Associations

    News

    Trials
    3ms
    Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing. (PubMed, Acta Pharm Sin B)
    Targeting RPS6 with vivo phosphorodiamidate morpholino oligomer (V-PMO) significantly inhibited the growth of CCA cells, patient-derived organoids, and subcutaneous xenograft tumor. Taken together, the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.
    Journal
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    RPS6 (Ribosomal Protein S6) • MCM7 (Minichromosome Maintenance Complex Component 7)
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    RPS6 overexpression
    1year
    MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response. (PubMed, Sci Rep)
    The negative role of UPR in GSIS is further supported by analysis of public transcriptomic data from murine islets. In all, our studies identify MRPS6 and UPR as novel modulators of GSIS and apoptosis in β-cells, contributing to our understanding of the molecular and cellular mechanisms of IGT, prediabetes, and diabetes.
    Preclinical • Journal
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    RPS6 (Ribosomal Protein S6)
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    RPS6 overexpression