^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    RPN2 (Ribophorin II)

    i
    Other names: RPN2, Ribophorin II, RIBIIR, RPN-II, RPNII, SWP1, Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 63 KDa Subunit, Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 2, Oligosaccharyltransferase Complex Subunit (Non-Catalytic), Ribophorin-2
    Associations

    News

    Trials
    6ms
    S100A16 knockdown reduces RPN2 expression and inhibits β-catenin/TCF signaling, leading to suppressed metastasis in cervical cancer cells. (PubMed, Biochim Biophys Acta Mol Cell Res)
    In conclusion, our research revealed that S100A16 silencing downregulated RPN2 levels through p-STAT3, thereby inhibiting the p-GSK3β/β-catenin/TCF signaling pathway. These findings highlight S100A16 as a potential therapeutic target for cervical cancer.
    Journal
    |
    STAT3 (Signal Transducer And Activator Of Transcription 3) • S100A16 (S100 Calcium Binding Protein A16) • RPN2 (Ribophorin II)
    almost3years
    YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1-RPN2-PI3K/AKT/mTOR Axis. (PubMed, Int J Mol Sci)
    Meanwhile, overexpression of the downstream target gene, RPN2, could rescue the effect of reduced METTL3/YTHDF1 expression on bladder cancer cells. In conclusion, this study proposes a novel METTL3/YTHDF1-RPN2-PI3K/AKT/mTOR regulatory axis that affects bladder cancer cell proliferation and cisplatin sensitivity.
    Journal
    |
    METTL3 (Methyltransferase Like 3) • RPN2 (Ribophorin II) • YTHDF1 (YTH N6-Methyladenosine RNA Binding Protein 1)
    |
    cisplatin