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    GENE:

    RPL10 (Ribosomal Protein L10)

    i
    Other names: RPL10, Ribosomal Protein L10, DXS648E, Large Ribosomal Subunit Protein UL16, 60S Ribosomal Protein L10, Laminin Receptor Homolog, Tumor Suppressor QM, DXS648, Wilms Tumor-Related Protein, Protein QM, FLJ23544, AUTSX5, MRXS35
    1m
    Transcriptome Sequencing and Differential Analysis of Testes of 1-Year-Old and 3-Year-Old Kazakh Horses. (PubMed, Biology (Basel))
    RT-qPCR validation confirmed the accuracy of the transcriptomic sequencing data. This study further elucidates the differentially expressed genes and associated signaling pathways in Kazakh stallion testes tissue before and after sexual maturity, providing a theoretical foundation and data reference for enhancing reproductive efficiency in equids and promoting biological processes such as testes development and spermatogenesis.
    Journal
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    CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • RPL10 (Ribosomal Protein L10)
    8ms
    Angio-associated migratory cell protein promotes colorectal cancer progression by enhancing phosphoglycerate kinase 1 phosphorylation. (PubMed, J Cell Commun Signal)
    RNA sequencing revealed AAMP modulation of immune-related pathways (Tumor Necrosis Factor, IL-17, Jak-STAT) and key proteins (EGFR, RPL10, NOD2), suggesting dual roles in proliferation. AAMP promotes CRC progression through PGK1 phosphorylation-dependent metabolic activation, proposing the AAMP-PGK1 axis as a therapeutic target for advanced CRC.
    Journal
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    EGFR (Epidermal growth factor receptor) • TNFA (Tumor Necrosis Factor-Alpha) • IL17A (Interleukin 17A) • AAMP (Angio Associated Migratory Cell Protein) • RPL10 (Ribosomal Protein L10) • PGK1 (Phosphoglycerate Kinase 1)
    9ms
    The characterisation of the complete mitochondrial genome of Polygonatum Kingianum reveals recombination mediated by repeats associated with DNA replication. (PubMed, Sci Rep)
    The phylogenetic tree established a close relationship between P. kingianum and the 27 closely related species. To sum up, this study will contribute to the application of population genetics and evolutionary research in the genus Polygonatum and other genera in the Asparagales family.
    Journal
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    RPL10 (Ribosomal Protein L10) • SDHC (Succinate Dehydrogenase Complex Subunit C) • SDHD (Succinate Dehydrogenase Complex Subunit D)
    over1year
    Integrated analysis of single-cell, spatial and bulk RNA-sequencing identifies a cell-death signature for predicting the outcomes of head and neck cancer. (PubMed, Front Immunol)
    ST from LSCC showed that spots with high-risk scores were colocalized with TGF-β and the proliferating malignant cells, additionally, the risk scores have a negative correlation with TCR signaling but positive association with LAG3 transcription. The CDRscore model could be utilized as a powerful prognostic indicator for HNC.
    Journal • IO biomarker
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    TP53 (Tumor protein P53) • LAG3 (Lymphocyte Activating 3) • EFNB2 (Ephrin B2) • PCM1 (Pericentriolar Material 1) • TGFB1 (Transforming Growth Factor Beta 1) • HPRT1 (Hypoxanthine Phosphoribosyltransferase 1) • RPL10 (Ribosomal Protein L10) • MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7)
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    TP53 mutation
    over1year
    Rare Drivers at Low Prevalence with High Cancer Effects in T-Cell and B-Cell Pediatric Acute Lymphoblastic Leukemia. (PubMed, Int J Mol Sci)
    Even CDKN2A, with a low prevalence and relatively modest cancer effect, is potentially highly relevant for the epistatic effects that its mutated form exerts on other mutations. Prioritizing investigation into these moderately frequent but potentially high-impact targets not only presents novel personalized therapeutic opportunities but also enhances the understanding of disease mechanisms and advances precision therapeutics for pediatric ALL.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • IL7R (Interleukin 7 Receptor) • RPL10 (Ribosomal Protein L10) • XBP1 (X-box-binding protein 1)
    over1year
    Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis. (PubMed, J Ovarian Res)
    Our results indicated that amplifications of these genes may play an important etiological role in teratoma formation. Moreover, amplifications of EVX2 and HOXD9-HOXD13 on 2q31.1, found on array comparative genomic hybridization, may help to explain the characteristics of teratomas in chondrogenesis and osteogenesis.
    Journal
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    RPL10 (Ribosomal Protein L10) • ATP6AP1 (ATPase H+ Transporting Accessory Protein 1)
    almost2years
    Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. (PubMed, Proc Natl Acad Sci U S A)
    However, combinations of copanlisib/afatinib and copanlisib/elimusertib were significantly more effective in controlling NETc tumor growth. These findings define the genetic landscape of NETc and suggest that a large subset of these highly lethal malignancies might benefit from existing targeted therapies.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1) • ARID1A (AT-rich interaction domain 1A) • KMT2D (Lysine Methyltransferase 2D) • NOTCH2 (Notch 2) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • MBD4 (Methyl-CpG Binding Domain 4, DNA Glycosylase) • PVT1 (Pvt1 Oncogene) • RPL10 (Ribosomal Protein L10)
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    KRAS mutation • PIK3CA mutation • ARID1A mutation • KMT2D mutation
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    Gilotrif (afatinib) • Aliqopa (copanlisib) • elimusertib (BAY 1895344)
    2years
    Transcriptomics analysis reveals distinct mechanism of breast cancer stem cells regulation in mammospheres from MCF-7 and T47D cells. (PubMed, Heliyon)
    Drug-gene association analysis revealed that both upregulated and downregulated DEGs were associated with fostamatinib...CMap analysis unveiled SA-83851 as a potential candidate to counteract the effects of DEGs, specifically in cells harbouring mutant TP53. Further research, including in vitro and in vivo validations, is warranted to develop drugs targeting BCSCs.
    Journal • Cancer stem
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    EPAS1 (Endothelial PAS domain protein 1) • ERO1A (Endoplasmic Reticulum Oxidoreductase 1 Alpha) • RPL10 (Ribosomal Protein L10) • PKM (Pyruvate Kinase M1/2) • SLC6A6 (Solute Carrier Family 6 Member 6) • NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase)
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    TP53 mutation • TP53 wild-type • TP53 expression
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    Tavalisse (fostamatinib)
    over2years
    The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma. (PubMed, Cell Death Dis)
    Moreover, the mutagenesis of ufmylation sites in RPL10 further demonstrated the connection of RPL10 ufmylation with cell proliferation and stemness. Collectively, this study reveals that PRL10 ufmylation plays an important role to enhance the stemness of pancreatic cancer cells for PAAD development.
    Journal
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    KLF4 (Kruppel-like factor 4) • RPL10 (Ribosomal Protein L10)
    over2years
    Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations. (PubMed, Breast Cancer Res)
    We observed significant differences in mutational spectra, gene expression, and relevant transcriptional signatures between patients with genetically determined African and European ancestries, particularly within the HR+/HER2- BC and TNBC subtypes. These findings could guide future development of treatment strategies by providing opportunities for biomarker-informed research and, ultimately, clinical decisions for precision oncology care in diverse populations.
    Journal • Real-world evidence • Real-world
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    HER-2 (Human epidermal growth factor receptor 2) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • KMT2C (Lysine Methyltransferase 2C) • ATRX (ATRX Chromatin Remodeler) • HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) • RPL10 (Ribosomal Protein L10)
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    HER-2 negative • PIK3CA mutation • KMT2C mutation • MLL3 mutation
    almost3years
    Identification of three small nucleolar RNAs (snoRNAs) as potential prognostic markers in diffuse large B-cell lymphoma. (PubMed, Cancer Med)
    Put together, our findings explored the potential biological effects of snoRNAs in DLBCL, and provided a new predictor for DLBCL prediction.
    Journal
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    RPL10 (Ribosomal Protein L10)