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    BIOMARKER:

    RPL10 R98S

    i
    Other names: RPL10, Ribosomal Protein L10, DXS648E, Large Ribosomal Subunit Protein UL16, 60S Ribosomal Protein L10, Laminin Receptor Homolog, Tumor Suppressor QM, DXS648, Wilms Tumor-Related Protein, Protein QM, FLJ23544, AUTSX5, MRXS35
    Entrez ID:
    6134
    3years
    Mutational analysis of ribosomal proteins in a cohort of pediatric patients with T-cell acute lymphoblastic leukemia reveals Q123R, a novel mutation in RPL10. (PubMed, Front Genet)
    In addition, our sequencing highlighted the presence of a novel mutation in RPL10, namely the Q123R, which we found associated with a defect in protein synthesis. Our findings indicate that genetic alterations involving ribosome biogenesis and translational control should be carefully considered in the context of precision medicine in T-ALL.
    Journal
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    RPL10 (Ribosomal Protein L10)
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    RPL10 R98S