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    GENE:

    RPA1 (Replication Protein A1)

    i
    Other names: RPA1, Replication Protein A1, Replication Protein A 70 KDa DNA-Binding Subunit, Single-Stranded DNA-Binding Protein, Replication Factor A Protein 1, Replication Protein A1 70kDa, RF-A Protein 1, RP-A P70, REPA1, RPA70, Replication Protein A1 (70kD), MSTP075, MST075, HSSB, RF-A, RP-A
    6d
    Clinicopathological and functional evaluation of replication protein A in epithelial ovarian cancers: A target validation study. (PubMed, Transl Oncol)
    Platinum resistant ovarian cancer cells were depleted for RPA 1 or 2 and tested for cisplatin, olaparib and talazoparib sensitivity. HAMNO monotherapy was cytotoxic to sensitive and resistant cells. We conclude that RPA directed precision oncology strategy could be a viable strategy in HGSOC.
    Journal • PARP Biomarker
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    RPA1 (Replication Protein A1) • RPA2 (Replication Protein A2)
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    Lynparza (olaparib) • cisplatin • Talzenna (talazoparib)
    8d
    HAT1 as a Lactyltransferase to Promote DNA Repair Through RPA1 Lactylation in Glioblastoma. (PubMed, Int J Biol Sci)
    Correspondingly, targeted inhibition of RPA1 lactylation at K88, using a competitive peptide, reverses radioresistance in GBM cells. Collectively, these findings establish the lactate-driven HAT1-RPA1 lactylation axis as a critical regulator of radioresistance and nominate both HAT1 and lactylated RPA1 as novel therapeutic targets in GBM.
    Journal
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    HAT1 (Histone Acetyltransferase 1) • RPA1 (Replication Protein A1)
    12d
    Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation. (PubMed, Adv Sci (Weinh))
    Targeting ASCOR with antisense oligonucleotides reverses chemoresistance in mouse models. Our study unveils an ascites circRNA-driven pathway underlying platinum resistance in HGSOC, suggesting targeting ASCOR is a promising strategy for HGSOC treatment.
    Journal
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    RPA1 (Replication Protein A1) • NUP153 (Nucleoporin 153)
    15d
    Condensins regulate resection-dependent DNA double-strand break repair pathways in replicated chromatin. (PubMed, Nucleic Acids Res)
    Cytogenetic analysis revealed inhibition of chromosome break repair and visible chromatin decondensation, suggesting that condensins function to maintain an appropriate chromatin state for efficient DSB repair in G2-phase. These results identify for the first time condensins as G2 phase-specific regulators of genome stability by fine-tuning HR and other resection-dependent DSB repair pathways.
    Journal
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    RAD51 (RAD51 Homolog A) • RPA1 (Replication Protein A1) • TP53BP1 (Tumor Protein P53 Binding Protein 1)
    26d
    Orf Infection Localized in the Earlobe: The First Case Report in the Literature (PubMed, Mikrobiyol Bul)
    In conclusion, it should be kept in mind that orf lesions may occur even in unexpected sites such as the periauricular region, particularly in patients living in rural areas with a history of animal contact. Early diagnosis of orf infection will prevent unnecessary aggressive surgical interventions and will also contribute to the proper follow-up of patients and the prevention of complications.
    Journal
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    RPA1 (Replication Protein A1)
    1m
    Fluzoparib as Adjuvant Treatment in Patients With Germline Homologous Recombination Repair (HRR) Mutated Primary Breast Cancer (Flamenco) (clinicaltrials.gov)
    P2, N=334, Not yet recruiting, Fudan University
    New P2 trial • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • PGR (Progesterone receptor) • RAD51 (RAD51 Homolog A) • RAD51B (RAD51 Paralog B) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • RAD51C (RAD51 paralog C) • RAD50 (RAD50 Double Strand Break Repair Protein) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • RAD51D (RAD51 paralog D) • BARD1 (BRCA1 Associated RING Domain 1) • NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)) • RAD54L (DNA Repair And Recombination Protein RAD54) • FANCM (FA Complementation Group M) • RAD52 (RAD52 Homolog DNA Repair Protein) • RPA1 (Replication Protein A1) • PARP2 (Poly(ADP-Ribose) Polymerase 2)
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    HER-2 negative • PALB2 mutation • PGR positive • BRIP1 mutation • RAD51C mutation • RAD51D mutation • RAD51B mutation • BARD1 mutation • RAD54L mutation
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    capecitabine • AiRuiYi (fluzoparib)
    2ms
    Single-stranded DNA-binding proteins at healthy and diseased telomeres. (PubMed, Trends Biochem Sci)
    Here, we review recent findings on the roles of SSBPs and their coordination during telomere replication and elongation. We also present recent advances on ssDNA-binding factors and their regulators in alternative lengthening of telomeres (ALTs), highlighting how these findings may provide viable therapeutic targets in ALT cancers.
    Review • Journal
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    RPA1 (Replication Protein A1)
    2ms
    NKX2-1 regulates cell survival, maturation, and DNA-damage responses as a cofactor of RUNX1 in T-cell acute lymphoblastic leukemia. (PubMed, Haematologica)
    Furthermore, NKX2-1 positive cells showed less induction of DNA damage and apoptosis upon treatment with etoposide, a DNA damaging chemotherapy agent that is clinically used to treat T-ALL...Notably, NKX2-1 expressing cells showed higher sensitivity towards RUNX1 inhibition, suggesting a cooperative role in regulating T-ALL cell survival. This work reveals a critical role of NKX2-1 in enhancing T-ALL cell survival through DNA damage protection, and identifies RUNX1 as an important cofactor in T-ALL pathogenesis.
    Journal
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    RUNX1 (RUNX Family Transcription Factor 1) • CDK6 (Cyclin-dependent kinase 6) • RPA1 (Replication Protein A1) • RPA2 (Replication Protein A2)
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    etoposide IV
    2ms
    Homologous Recombination Is Associated with Enhanced Anti-Tumor Innate Immunity and Favorable Prognosis in Head and Neck Cancer. (PubMed, Cancers (Basel))
    Together, our findings provide a comprehensive overview of the HR pathway in HNSCC, highlighting the dual role of HR proteins in both genomic maintenance and immune regulation. The consistent upregulation of HR proteins, their association with disease progression, and potential immunogenic effects underscore their promise as diagnostic/prognostic biomarkers and therapeutic targets in HNSCC.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PALB2 (Partner and localizer of BRCA2) • RAD51 (RAD51 Homolog A) • STING (stimulator of interferon response cGAMP interactor 1) • MRE11A (MRE11 homolog, double strand break repair nuclease) • STAT1 (Signal Transducer And Activator Of Transcription 1) • LRIG1 (Leucine Rich Repeats And Immunoglobulin Like Domains 1) • RPA1 (Replication Protein A1) • RPA2 (Replication Protein A2)
    2ms
    Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells. (PubMed, bioRxiv)
    Our findings establish that fumarate-induced succination of RPA1 impairs DNA repair and cell cycle control, promoting genomic instability in FH-dRCC. This work reveals a novel mechanism by which oncometabolites contribute to genomic instability.
    Journal
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    FH (Fumarate Hydratase) • RPA1 (Replication Protein A1)
    3ms
    RPA1, RFC1, and POLE Expression in Clear Cell Renal Cell Carcinoma: Immune and Clinical Relevance. (PubMed, Anticancer Res)
    DNA replication proteins interact with systemic inflammation and the TME in ccRCC, supporting their role as biomarkers and potential therapeutic targets.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • POLE (DNA Polymerase Epsilon) • CD4 (CD4 Molecule) • RPA1 (Replication Protein A1) • RFC4 (Replication Factor C Subunit 4)
    3ms
    HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma. (PubMed, Cell Death Dis)
    Interestingly, we also found that K15 auto-lactylation of HAT1 can modulate its lactyltransferase activity. In conclusion, our research reveals that HAT1-regulated RPA1 lactylation plays an important role in homologous recombination and radioresistance, suggesting that HAT1 may become a potential therapeutic target for reversing the radioresistance caused by lactate accumulation in cancer cells.
    Journal
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    RAD50 (RAD50 Double Strand Break Repair Protein) • HAT1 (Histone Acetyltransferase 1) • RPA1 (Replication Protein A1)