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    BIOMARKER:

    ROS1 G2032R + ROS1 L2086F

    i
    Other names: ROS1, ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1, C-Ros Oncogene 1 Receptor Tyrosine Kinase, Proto-Oncogene Tyrosine-Protein Kinase ROS, Proto-Oncogene C-Ros-1, MCF3, ROS, V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian), ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, Transmembrane Tyrosine-Specific Protein Kinase, Receptor Tyrosine Kinase C-Ros Oncogene 1, C-Ros Receptor Tyrosine Kinase, Proto-oncogene C-Ros, C-Ros-1
    Entrez ID:
    6098
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over2years
    A Phase 2 Study of Lorlatinib in Patients With ROS1-Rearranged Lung Cancer With Brain-Only Progression on Crizotinib. (PubMed, JTO Clin Res Rep)
    No grade greater than or equal to 4 adverse events were observed. Lorlatinib induced durable intracranial responses in patients with ROS1-rearranged NSCLC and prior isolated CNS progression on crizotinib.
    P2 data • Journal
    |
    RET (Ret Proto-Oncogene) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • CCDC6 (Coiled-Coil Domain Containing 6)
    |
    RET fusion • ROS1 fusion • CCDC6-RET fusion • ROS1 rearrangement • ROS1 G2032R • ROS1 L2086F • ROS1 G2032R + ROS1 L2086F
    |
    Xalkori (crizotinib) • Lorbrena (lorlatinib)
    almost3years
    Phase II Study of Lorlatinib in Patients with ROS1-Rearranged Lung Cancer with CNS Progression on Crizotinib (IASLC-TTLC 2022)
    No grade 5 adverse events were observed. The study was terminated early after enrollment of 16 of 22 planned patients due to the commercial availability of off-label lorlatinib.Conclusion s : The CNS-penetrant next-generation ROS1 inhibitor lorlatinib is an effective salvage therapy for patients experiencing isolated CNS progression on crizotinib.
    Clinical • P2 data
    |
    RET (Ret Proto-Oncogene) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • CCDC6 (Coiled-Coil Domain Containing 6)
    |
    RET fusion • ROS1 fusion • CCDC6-RET fusion • ROS1 rearrangement • ROS1 G2032R • ROS1 L2086F • ROS1 G2032R + ROS1 L2086F
    |
    Xalkori (crizotinib) • Lorbrena (lorlatinib)