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BIOMARKER:

ROS1 expression

i
Other names: ROS1, ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1, C-Ros Oncogene 1 Receptor Tyrosine Kinase, Proto-Oncogene Tyrosine-Protein Kinase ROS, Proto-Oncogene C-Ros-1, MCF3, ROS, V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian), ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, Transmembrane Tyrosine-Specific Protein Kinase, Receptor Tyrosine Kinase C-Ros Oncogene 1, C-Ros Receptor Tyrosine Kinase, Proto-oncogene C-Ros, C-Ros-1
Entrez ID:
1m
Apurinic/apyrimidinic endonuclease 1 alleviates inflammation in fibroblast-like synoviocytes from patients with rheumatoid arthritis. (PubMed, Cent Eur J Immunol)
Notably, APEX1 downregulated cell migration of TNF-α/IL-17-treated RA FLS via inhibition of matrix metalloproteinase 3 (MMP3). These findings collectively underscore the role of APEX1 as a key mediator of cytokine-amplified migration, modulating ROS and MMP3 in RA FLS, thus supporting its potential as a therapeutic target in RA treatment.
Journal
|
IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL17A (Interleukin 17A) • APEX1 (Apurinic/Apyrimidinic Endodeoxyribonuclease 1) • MMP3 (Matrix metallopeptidase 3)
|
ROS1 expression
2ms
Involvement of ICAM5 in Carcinostasis Effects on LUAD Based on the ROS1-Related Prognostic Model. (PubMed, J Inflamm Res)
PLX4720 may be a suitable treatment for the high-risk patient population...Personalized therapy may play an essential role in treatment. We further investigated the role of ICAM5 in inhibiting the malignant bioactivity of LUAD cells.
Journal • IO biomarker
|
ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • ICAM5 (Intercellular Adhesion Molecule 5)
|
ROS1 fusion • ROS1 expression
|
PLX4720
2ms
Role of the GalNAc-galectin pathway in the healing of premature rupture of membranes. (PubMed, Mol Med)
GalNAc might be a potential target for the prevention and treatment of PROM through the galectin pathway, including (i) inflammation; (ii) epithelial-mesenchymal transition; (iii) proliferation and migration; and (iv) regression, remodeling, and healing.
Journal
|
IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • LGALS3 (Galectin 3)
|
IL6 expression • ROS1 expression
8ms
Targeting ERBB2 and PIK3R1 as a therapeutic strategy for dilated cardiomyopathy: A single-cell sequencing and mendelian randomization analysis. (PubMed, Heliyon)
We found that everolimus was a pharmacological inhibitor for both PIK3R1 and ERBB2...In addition, there is a cross-expression of PIK3R1 and ERBB2 genes in both DCM and tumors. The adaptive immune system and PIK3R1 may be involved in DCM disease progression, while ERBB2 exerts a protective effect against DCM.
Journal
|
HER-2 (Human epidermal growth factor receptor 2) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1)
|
HER-2 expression • ROS1 expression
|
everolimus
9ms
Therapeutic potential of HUC-MSC-exos primed with IFN-γ against LPS-induced acute lung injury. (PubMed, Iran J Basic Med Sci)
IFN-γ-exos reduced oxidative stress and inflammatory responses in LPS-induced A549 cells and mice. The result demonstrated the therapeutic potential of IFN-γ-exos in LPS-induced ALI.
Journal • IO biomarker
|
IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • RELA (RELA Proto-Oncogene)
|
IDO1 expression • ROS1 expression
10ms
TNF-α promotes expression of inflammatory factors by upregulating nicotinamide adenine dinucleotide phosphate oxidase-2 expression in human gingival fibroblasts. (PubMed, J Dent Sci)
Compared with the si-NC group, the mRNA and protein expression levels of IL-6 and MCP-1 were significantly down-regulated and ROS expression was significantly decreased in the si-NOX2 group stimulated by 10 ng/ml TNF-α. TNF-α promotes the expression of NOX-2 in human gingival fibroblasts and enhances the expression of inflammatory factors and ROS in human gingival fibroblasts through the upregulation of NOX-2 partly.
Journal
|
IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha)
|
IL6 expression • ROS1 expression
10ms
Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling. (PubMed, Biomark Res)
Our study demonstrates that the combination of IN10018 and crizotinib shows synergistic antitumor effects in TNBC. Mechanistically, this combination inhibits cell proliferation, enhances apoptosis, and induces ferroptosis, which is associated with increased p53 levels.
Journal • PARP Biomarker • IO biomarker
|
ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • GPX4 (Glutathione Peroxidase 4) • CASP9 (Caspase 9) • CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1)
|
ROS1 expression
|
Xalkori (crizotinib) • ifebemtinib (IN10018)
11ms
Preclinical evidence for anaplastic lymphoma kinase inhibitors as novel therapeutic treatments for cholangiocarcinoma. (PubMed, Front Oncol)
Whereas capmatinib did not affect cell survival, ceritinib dose-dependently inhibited survival in all cell lines, with IC ranging from 1 to 9 µM and co-treatments with gemcitabine and cisplatin further sensitized cells, with IC ranging from IC 0.60 to 2.32 µM...Only ceritinib inhibited 3D growth of all four patient samples below mean peak serum concentration, in the presence and absence of mesenchymal cells, whereas crizotinib and capmatinib failed to do this. Ceritinib appeared to exert its effect more through autophagy than apoptosis. These results indicate that ceritinib or other ALK/ROS inhibitors could be therapeutically useful in cholangiocarcinoma even in the absence of aberrant ALK/ROS1 expression.
Preclinical • Journal
|
ALK (Anaplastic lymphoma kinase)
|
ALK rearrangement • ROS1 expression
|
cisplatin • Xalkori (crizotinib) • gemcitabine • Zykadia (ceritinib) • Tabrecta (capmatinib)
11ms
Hyaluronic Acid-modified Liposomes for Ursolic Acid-targeted Delivery Treat Lung Cancer Based on p53/ARTS-mediated Mitochondrial Apoptosis. (PubMed, Iran J Pharm Res)
HA-Lipo/UA induced overexpression of reactive oxygen species and upregulated expression of p53 and apoptosis-related protein in the transforming growth factor-β signaling (ARTS) pathway, which induced cytochrome-c release, activation of caspase-3, and promoted mitochondrial apoptosis in A549 cells. Taken together, these data suggested that HA-Lipo/UA could be used to target tumor cells.
Journal
|
CASP3 (Caspase 3)
|
TP53 expression • ROS1 expression
11ms
Ajmalicine induces the pyroptosis of hepatoma cells to exert the antitumor effect. (PubMed, J Biochem Mol Toxicol)
The AJM-induced pyroptosis was suppressed after N-acetylcysteine treatment to inhibit ROS, while Caspase-3 knockdown also inhibited the AJM-induced pyroptosis. In animals, AJM suppressed tumor growth. AJM can activate ROS to induce pyroptosis and exert the antitumor effect via the noncanonical Caspase-3-GSDME pyroptosis pathway.
Journal
|
IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • IL1B (Interleukin 1, beta) • GSDME (Gasdermin E)
|
ROS1 expression
1year
Translation Inhibition through eIF4A1 Targeting in Multiple Myeloma Is a Promising Therapeutic Strategy (ASH 2023)
We investigated the link between Roca sensitivity and the response of HMCLs to MM drugs, and found that higher resistance to Bortezomib was associated with higher sensitivity to Roca (n = 10, r = -0.6, p value < 0.05). A synergy between Roca and Lenalidomide was identified in HMCLs, suggesting that the downregulation of MM oncoproteins with Roca could be used to increase the efficacy of IMIDs. In conclusion, Rocaglamide combination with IMIDs or other targeted therapies, such as EZH2 inhibitors, could be of clinical interest and represents a promising strategy to improve the outcome of MM patients.
IO biomarker
|
TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • IKZF1 (IKAROS Family Zinc Finger 1) • RECQL (RecQ Like Helicase) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2)
|
MYC expression • IKZF2 expression • ROS1 expression
|
lenalidomide • bortezomib
1year
Expanding the clinical and histomorphologic spectrum of ROS1-associated Spitz nevi: A study of 13 cases (ASDP 2023)
Although we were unable to correlate a distinct histomorphologic feature with this driver mutation, we identified for the first time two cases with Reed-like features. Poster type: Poster Defense
Clinical
|
ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
ROS1 expression
1year
Oxidative Stress-induced liver damage and remodeling of the liver vasculature. (PubMed, Am J Pathol)
This review provides a detailed perspective on various stress-induced factors and the specific focus on role of oxidative stress in different liver diseases with special emphasis on different molecular mechanisms. It also highlights how resultant changes in the liver vasculature corelates with pathogenesis.
Review • Journal
|
ROS1 expression
1year
Antisense lncRNA-RP11-498C9.13 promotes bladder cancer progression by enhancing reactive oxygen species-induced mitophagy. (PubMed, J Gene Med)
We demonstrated that lncRNA-RP11-498C9.13 promoted bladder cancer tumorigenesis by stabilizing the mRNA of PYCR1 and promoted ROS-induced mitophagy. The lncRNA-RP11-498C9.13/PYCR1/mitophagy axis was anticipated to be a significant therapeutic target for bladder cancer.
Journal
|
PRO-C3 (Pyrroline-5-carboxylate reductase) • PYCR1 (Pyrroline-5-Carboxylate Reductase 1)
|
ROS1 expression
1year
Coleus vettiveroides ethanolic root extract induces cytotoxicity by intrinsic apoptosis in HepG2 cells. (PubMed, J Appl Toxicol)
CV also induced mitochondria-mediated apoptosis, as evidenced by increased expression of p53, Bax, cytochrome C, Apaf-1, PARP, caspase-3 and caspase-9, and downregulated Bcl-2 expression. Therefore, CV exerts its anticancer effect by inducing mitochondrial dysfunction, oxidative stress, cytoskeletal disorganization, cell cycle arrest, and mitochondria-mediated apoptosis, and it could be a potent therapeutic option for HCC.
Journal • PARP Biomarker • IO biomarker
|
TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • APAF1 (Apoptotic peptidase activating factor 1)
|
BCL2 expression • TP53 expression • BAX expression • ROS1 expression
1year
IKAROS: from chromatin organization to transcriptional elongation control. (PubMed, Cell Death Differ)
We highlight the dynamic regulation of this factor by post-translational modifications. Finally, potential avenues to explain how IKAROS destruction may be favorable in the treatment of certain hematological malignancies are also explored.
Review • Journal
|
IKZF1 (IKAROS Family Zinc Finger 1)
|
IKZF2 expression • ROS1 expression
over1year
Mitophagy-mediated inflammation and oxidative stress contribute to muscle wasting in cancer cachexia. (PubMed, J Clin Biochem Nutr)
Meanwhile, ATP production was undermined, indicating a close relationship with mitophagy, inflammation, and oxidative stress in the skeletal muscle of cancer cachexia mice models. In conclusion, mitophagy is activated in cancer cachexia and may play a role in skeletal muscle atrophy, and inflammation and oxidative stress might participate in mitophagy-related skeletal muscle injury.
Journal
|
ROS1 expression
over1year
Upregulation and the clinical significance of KCNQ1OT1 and HAGLROS lncRNAs in papillary thyroid cancer: An observational study. (PubMed, Medicine (Baltimore))
When only microcarcinoma samples were evaluated, KCNQ1OT1 expression was higher in tumor tissues compared to normal tissues; however, no significant difference was observed in HAGLROS expression. Our data suggests that high expressions of KCNQ1OT1 and HAGLROS might contribute to the development of PTC and disease progression, and both lncRNAs may be potential therapeutic targets in PTC patients.
Observational data • Journal
|
KCNQ1OT1 (KCNQ1 Opposite Strand/Antisense Transcript 1)
|
ROS1 expression
over1year
Routine Clinically Detected Increased ROS1 Transcripts Are Related With ROS1 Expression by Immunohistochemistry and Associated With EGFR Mutations in Lung Adenocarcinoma. (PubMed, JTO Clin Res Rep)
Moreover, we have found a mean statistically significant relationship between ROS1 expression and EGFR gene mutations, suggesting a crosstalk mechanism between these oncogenic driver molecules. This study demonstrates that ROS1 IHC represents true ROS1 mRNA expression, and raises the question of a potential benefit of combined targeted therapy in EGFR-mutated NSCLC.
Journal
|
EGFR (Epidermal growth factor receptor) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
EGFR mutation • EGFR expression • ROS1 positive • ROS1 rearrangement • ROS1 expression
over1year
Effect and mechanism of Dahuang Zhechong Pills in improving liver aging in rats by regulating ROS-mediated PI3K/Akt/FoxO4 signaling pathway (PubMed, Zhongguo Zhong Yao Za Zhi)
Based on the D-gal-induced LA model in rats, this study demonstrates that DHZCP can ameliorate LA with multiple targets in vivo, and its effects and mechanism are related to regulating the activation of the ROS-mediated PI3K/Akt/FoxO4 signaling pathway in the liver. These findings are expected to provide new pharmacological evidence for the treatment of DHZCP in aging-related liver diseases.
Preclinical • Journal
|
TP53 (Tumor protein P53) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • H2AX (H2A.X Variant Histone)
|
TP53 expression • IL6 expression • ROS1 expression
over1year
"Evaluation of ROS1 expression and rearrangements in a large cohort of early-stage lung cancer". (PubMed, Diagn Pathol)
ROS1 seems to be less frequent in early-stage disease than in advanced stages. IHC is a sensitive, but less specific method and the results need to be confirmed with another method like FISH or NGS.
Journal
|
TP53 (Tumor protein P53) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
TP53 mutation • ROS1 fusion • ROS1 positive • ROS1 expression
over1year
Ikaros expression is associated with an increased risk of chronic graft-versus-host disease. (PubMed, Sci Rep)
In conclusion, Ikaros expression in the graft and in the recipients' PB after transplantation was associated with a higher risk of moderate/severe chronic GVHD. Ikaros expression should be evaluated in larger prospective trials as a potential biomarker for chronic GVHD.
Journal
|
IKZF1 (IKAROS Family Zinc Finger 1)
|
IKZF2 expression • ROS1 expression
over1year
CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer. (PubMed, J Transl Med)
Our findings established CEBPG as a novel transcriptional regulator of OC ferroptosis, with potential value in predicting clinical outcomes and as a therapeutic candidate.
Journal
|
SLC7A11 (Solute Carrier Family 7 Member 11)
|
ROS1 expression
over1year
Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment. (PubMed, Biochim Biophys Acta Mol Basis Dis)
Like the cognate RXFP1 ligand RLN-2 and the small molecule RXFP1 agonist ML-290, CTRP8 reduced degranulation of ROSA MC stimulated by the Ca-ionophore A14187. In conclusion, this is the first report to identify the RXFP1 agonist CTRP8 as a novel marker of MC and autocrine/paracrine oncogenic factor within the PC microenvironment.
Journal
|
TNFA (Tumor Necrosis Factor-Alpha)
|
ROS1 expression
almost2years
PROS1 shapes the immune-suppressive tumor microenvironment and predicts poor prognosis in glioma. (PubMed, Front Immunol)
Increased expression of PROS1 was correlated with malignant phenotype and associated with poor prognosis in glioma. Besides, PROS1 could be a possible biomarker and potential immunotherapeutic target through promoting the glioma immunosuppressive microenvironment and inducing tumor-associated macrophages M2 polarization.
Journal • IO biomarker
|
NCAM1 (Neural cell adhesion molecule 1)
|
ROS1 expression
almost2years
Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach. (PubMed, iScience)
CTD/WGCNA multigene biomarkers are predictive in PDX datasets (RNAseq and Affymetrix) for both taxane- (docetaxel or paclitaxel) and platinum-based (carboplatin or cisplatin) response, thereby demonstrating cross-expression platform and cross-drug class robustness. These biomarkers were also predictive in clinical datasets, thus demonstrating translational potential.
Journal • PARP Biomarker
|
MAGEA4 (Melanoma antigen family A, 4) • ARHGDIB (Rho GDP Dissociation Inhibitor Beta) • SEC14L2 (SEC14 Like Lipid Binding 2)
|
ROS1 expression
|
cisplatin • carboplatin • paclitaxel • docetaxel
almost2years
Distinct Profiles of DNA Repair Activity Define Favorable-risk Prostate Cancer Subtypes With Divergent Outcome. (PubMed, Clin Genitourin Cancer)
Cluster I is a novel subgroup of favorable-risk disease with high DDR activity, AR activity, PARP1 and chr8q/MYC expression, and poorer MFS and OS.
Journal • PARP Biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog)
|
MYC expression • ROS1 expression
2years
HAGLROS knockdown restrained cell proliferation, migration and invasion and facilitated apoptosis in laryngeal cancer via miR-138-5p/CLN5 axis. (PubMed, J Clin Lab Anal)
Silenced HAGLROS restrained the LC cells' abilities to proliferate, migrate, and invade as well as facilitated apoptosis in LC via miR-138-5p/CLN5 axis.
Journal • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • MIR138 (MicroRNA 138)
|
BCL2 expression • BAX expression • ROS1 expression
2years
SNP rs9387478 at ROS1-DCBLD1 Locus is Significantly Associated with Lung Cancer Risk and Poor Survival in Indian Population. (PubMed, Asian Pac J Cancer Prev)
Overall, our study provides strong evidence that rs9387478 is significantly associated with both nicotine dependence and lung cancer in our North Indian cohort. The association of the SNP with prognostic genes, DCBLD1 and ROS1 make rs9387478 a promising prognostic marker in the North Indian population. The results obtained are significant, however, the study needs to be performed in a larger sample size.
Journal
|
ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
ROS1 expression
2years
Substrate stiffness effect on molecular crosstalk of epithelial-mesenchymal transition mediators of human glioblastoma cells. (PubMed, Front Oncol)
Finally, we observed that cells more motile showed a more depolarized mitochondrial membrane potential. Unravelling the process that regulates GBM cells' infiltrative behavior could provide new opportunities for identification of new targets and less invasive approaches for treatment.
Journal
|
EGFR (Epidermal growth factor receptor) • CDH2 (Cadherin 2)
|
EGFR expression • ROS1 expression
2years
Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care Therapy. (PubMed, Cancers (Basel))
We identified a role for EGFR pathway activation in the expression of mACE2 in NSCLC cells, associated with increased sACE2 levels in patients. Therefore, it is of great interest to study SARS-CoV-2-infected EGFR-mutated NSCLC patients in greater depth in order to obtain a better understanding of how mACE2, sACE2, and SOC TKIs can affect the course of COVID-19.
Journal • IO biomarker
|
HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • HRAS (Harvey rat sarcoma viral oncogene homolog) • TMPRSS2 (Transmembrane serine protease 2) • FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme)
|
KRAS mutation • EGFR mutation • HER-2 expression • MET expression • EGFR mutation + KRAS mutation • ROS1 expression • KRAS expression
2years
Valproic Acid Inhibits Peripheral T Cell Lymphoma Cells Behaviors via Restraining PI3K/AKT Pathway. (PubMed, Evid Based Complement Alternat Med)
The combination of VPA and miR-3196 mimics has the most obvious effect. VPA can inhibit the proliferation of Hut 78 cells and promote cell apoptosis and the structure and dysfunction of mitochondria by regulating the activity of the PI3K/AKT pathway.
Journal • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • CASP3 (Caspase 3)
|
BCL2 expression • ROS1 expression
over2years
BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas. (PubMed, Cancers (Basel))
These findings were corroborated by multicolor immunohistochemistry, where class 2/BAP1-mutant UMs demonstrated increased PROS1 expression in tumor cells and increased MERTK phosphorylation in CD163+ macrophages compared with class 1/BAP1-wildtype UMs. Taken together, these findings provide a mechanistic link between BAP1 loss and the suppression of the tumor immune microenvironment in class 2 UMs, and they implicate the PROS1-MERTK pathway as a potential target for immunotherapy in UM.
Journal • IO biomarker
|
BAP1 (BRCA1 Associated Protein 1) • CD163 (CD163 Molecule) • MERTK (MER Proto-Oncogene, Tyrosine Kinase)
|
ROS1 expression
over2years
Journal • PARP Biomarker
|
CASP3 (Caspase 3)
|
ROS1 expression
|
carfilzomib
over2years
LncRNA RP3-525N10.2-NFKB1-PROS1 triplet-mediated low PROS1 expression is an onco-immunological biomarker in low-grade gliomas: a pan-cancer analysis with experimental verification. (PubMed, J Transl Med)
long non-coding RNA RP3-525N10.2-NFKB1-PROS1 triplet-mediated PROS1 expression could serve as a biomarker for cancer diagnosis, prognosis, therapy selection, and follow-up in LGG patients.
Journal • IO biomarker • Pan tumor
|
NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1)
|
ROS1 expression
over2years
Glutor, a Glucose Transporter Inhibitor, Exerts Antineoplastic Action on Tumor Cells of Thymic Origin: Implication of Modulated Metabolism, Survival, Oxidative Stress, Mitochondrial Membrane Potential, pH Homeostasis, and Chemosensitivity. (PubMed, Front Oncol)
Glutor also enhanced the chemosensitivity of tumor cells to cisplatin, accompanied by decreased MDR1 expression...These results demonstrate that in addition to inhibited glucose uptake, modulated tumor growth regulatory molecular pathways are also implicated in the manifestation of the antineoplastic action of glutor. Thus, the novel findings of this study will have a long-lasting clinical significance in evaluating and optimizing the use of glutor in anticancer therapeutic strategies.
Journal • IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • LDHA (Lactate dehydrogenase A) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • IL2RA (Interleukin 2 receptor, alpha) • IL2 (Interleukin 2) • BAX (BCL2-associated X protein)
|
BCL2 expression • BAX expression • HIF1A expression • ROS1 expression • BCL2/BAX ratio elevation
|
cisplatin
over2years
Tracking ROS1 Fusions in NSCLC - Mirage or Truth When Screening the Desert (IASLC-WCLC 2022)
Our data indicate that the occurrence of ROS1 fusions is exceedingly low in resected NSCLC. IHC assays are able to detect this fusion, however, the accuracy is variable depending on the used clone. The false positive FISH and several uncertain FISH results neither support the use of FISH as a screening nor as a reference Method to detect ROS1-rearrangement in NSCLC.
ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
ROS1 fusion • ROS1 positive • ROS1 rearrangement • ROS1 expression
|
VENTANA ROS1 (SP384) Rabbit Monoclonal Primary Antibody
over2years
The prognostic role of PD-1, PD-L1, ALK, and ROS1 proteins expression in non-small cell lung carcinoma patients from Egypt. (PubMed, J Egypt Natl Canc Inst)
Positive ALK expression and EGFR-mutations are independent adverse predictors of NSCLC. Overexpression of PD-1/PD-L1 is not a significant prognostic marker in NSCLC patients receiving chemotherapy, making them susceptible to immunotherapy. Since PD-1/PD-L1 expression is independent to oncogenic driver mutations, future studies into specific immune checkpoint inhibitors combined with targeted therapies for individualized treatment of NSCLC is warranted. Positive ALK expression and EGFR mutations are independent risk factors for NSCLC. Overexpression of PD-1/PD-L1 is not a significant prognostic factor in patients with NSCLC who are receiving chemotherapy, making them immunotherapy susceptible. Given that PD-1/PD-L1 expression is not dependent on oncogenic driver mutations, additional research into specific immune checkpoint inhibitors in combination with targeted therapies for the treatment of NSCLC on an individual basis is warranted.
Journal • PD(L)-1 Biomarker • IO biomarker
|
EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • PD-1 (Programmed cell death 1)
|
PD-L1 expression • EGFR mutation • ALK positive • EGFR expression • EGFR wild-type • ALK mutation • ROS1 positive • PD-1 overexpression • ROS1 rearrangement • PD-1 expression • ALK negative • ROS1 expression
over2years
A Single-Institute Experience with C-ros Oncogene 1 Translocation in Non-Small Cell Lung Cancers in Taiwan. (PubMed, Int J Mol Sci)
Overall survival and progression-free survival were better in the 19 ROS1-translocated NSCLCs of the prospective group with crizotinib treatment than the four ROS1-translocated NSCLCs of the retrospective group without crizotinib treatment. (4) ROS1-translocated NSCLCs had a poor prognosis and could have a beneficial outcome with crizotinib.
Retrospective data • Journal
|
EGFR (Epidermal growth factor receptor) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
EGFR mutation • EGFR expression • EGFR wild-type • ROS1 positive • ROS1 expression
|
Xalkori (crizotinib)
over2years
Amentoflavone promotes ferroptosis by regulating reactive oxygen species (ROS) /5'AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) to inhibit the malignant progression of endometrial carcinoma cells. (PubMed, Bioengineered)
NAC reversed the effects of AF on biological behaviors of KLE cells by inactivating ROS/AMPK/mTOR signaling. In conclusion, AF promoted ferroptosis by activating ROS/AMPK/mTOR to inhibit the viability and proliferation and promoted the apoptosis and ferroptosis of KLE cells.
Journal
|
AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
|
ROS1 expression • AMPK expression
over2years
Long non-coding RNA HAGLROS facilitates the malignant phenotypes of NSCLC cells via repressing miR-100 and up-regulating SMARCA5. (PubMed, Biomed J)
These results conclude that HAGLROS is a tumor promoter in NSCLC, and it regulates the malignant phenotypes of NSCLC cells via miR-100/SMARCA5 axis.
Journal
|
MIR100 (MicroRNA 100)
|
ROS1 expression • miR-100 expression