These data implicate WNT5A-ROR2 in VEGF secretion, vascularity, adverse outcomes and bevacizumab sensitivity of BRAF melanomas, suggesting that this axis has potential therapeutic relevance.
over 1 year ago
Journal
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BRAF (B-raf proto-oncogene) • ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2) • WNT5A (Wnt Family Member 5A)
Therefore, ROR2 appears to regulate the cell cycle through Aurora kinases. The present results reveal a role for ROR2 in SCLC and afford a candidate system (ROR2-Aurora kinase) accompanying tumor heterogeneity in SCLC.
over 1 year ago
Journal
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ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2)