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BIOMARKER:

ROR2 overexpression

i
Other names: ROR2, Receptor Tyrosine Kinase Like Orphan Receptor 2, NTRKR2, Tyrosine-Protein Kinase Transmembrane Receptor ROR2, BDB1, BDB, Neurotrophic Tyrosine Kinase, Receptor-Related 2, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Neurotrophic Tyrosine Kinase Receptor-Related 2
Entrez ID:
over1year
WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma. (PubMed, Cell Oncol (Dordr))
These data implicate WNT5A-ROR2 in VEGF secretion, vascularity, adverse outcomes and bevacizumab sensitivity of BRAF melanomas, suggesting that this axis has potential therapeutic relevance.
Journal
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BRAF (B-raf proto-oncogene) • ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2) • WNT5A (Wnt Family Member 5A)
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BRAF mutation • BRAF wild-type • ROR2 overexpression • WNT5A expression
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Avastin (bevacizumab)
over1year
Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer. (PubMed, Hum Cell)
Therefore, ROR2 appears to regulate the cell cycle through Aurora kinases. The present results reveal a role for ROR2 in SCLC and afford a candidate system (ROR2-Aurora kinase) accompanying tumor heterogeneity in SCLC.
Journal
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ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2)
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ROR2 overexpression