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    BIOMARKER:

    ROR2 overexpression

    i
    Other names: ROR2, Receptor Tyrosine Kinase Like Orphan Receptor 2, NTRKR2, Tyrosine-Protein Kinase Transmembrane Receptor ROR2, BDB1, BDB, Neurotrophic Tyrosine Kinase, Receptor-Related 2, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Neurotrophic Tyrosine Kinase Receptor-Related 2
    Entrez ID:
    4920
    2ms
    WNT1/ROR2 pathway enhances the Triple-Negative breast cancer invasion, migration, and Epithelial-Mesenchymal transition. (PubMed, J Biochem Mol Toxicol)
    Finally, the mouse model experiments further validated the anticancer effect of PP on TNBC. Generally speaking, the malignant progression of TNBC could be stimulated by the WNT1/ROR2 signaling pathway which can be inhibited by PP, suggesting the potential value of PP in controlling TNBC.
    Journal
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    ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2)
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    ROR2 overexpression
    8ms
    miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression. (PubMed, Cancer Gene Ther)
    Mechanistically, miR-124-3p and miR-194-5p synergistically regulated the ROR2/PI3K/Akt pathway, influencing MB progression. Our findings indicate that miR-124-3p and miR-194-5p function as tumor suppressors, inhibiting MB progression via the ROR2/PI3K/Akt axis, suggesting a key mechanism and therapeutic targets for MB patients.
    Journal
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    ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2) • MIR194 (MicroRNA 194) • MIR124-3 (MicroRNA 124-3)
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    ROR2 overexpression
    almost2years
    WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma. (PubMed, Cell Oncol (Dordr))
    These data implicate WNT5A-ROR2 in VEGF secretion, vascularity, adverse outcomes and bevacizumab sensitivity of BRAF melanomas, suggesting that this axis has potential therapeutic relevance.
    Journal
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    BRAF (B-raf proto-oncogene) • ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2) • WNT5A (Wnt Family Member 5A)
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    BRAF mutation • BRAF wild-type • ROR2 overexpression • WNT5A expression
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    Avastin (bevacizumab)
    2years
    Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer. (PubMed, Hum Cell)
    Therefore, ROR2 appears to regulate the cell cycle through Aurora kinases. The present results reveal a role for ROR2 in SCLC and afford a candidate system (ROR2-Aurora kinase) accompanying tumor heterogeneity in SCLC.
    Journal
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    ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2)
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    ROR2 overexpression