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    BIOMARKER:

    ROR1 overexpression

    i
    Other names: ROR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Inactive Tyrosine-Protein Kinase Transmembrane Receptor ROR1, Neurotrophic Tyrosine Kinase, Receptor-Related 1, NTRKR1, DJ537F10.1, ROR1
    Entrez ID:
    4919
    Related biomarkers:
    Expression
    5d
    Exosomal lncRNA ROR1-AS1 from cancer-associated fibroblasts inhibits ferroptosis of lung cancer cells through the IGF2BP1/SLC7A11 signal axis. (PubMed, Cell Signal)
    CAFs secrete exosomal ROR1-AS1 to promote the expression of SLC7A11 by interacting with IGF2BP1, thereby inhibiting ferroptosis of lung cancer cells.
    Journal
    |
    ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • SLC7A11 (Solute Carrier Family 7 Member 11)
    |
    ROR1 expression • IGF2 overexpression • IGF2BP1 overexpression • SLC7A11 expression • ROR1 overexpression
    |
    erastin
    18d
    Dihydroartemisinin inhibits tumor progress via blocking ROR1-induced STAT3-activation in non-small cell lung cancer. (PubMed, Int Immunopharmacol)
    Finally, we found that ROR1 overexpression could partially reverse the decreased activity of STAT3 induced by DHA which indicates that DHA-induced anti-growth signaling is conferred, at least in part, through blocking ROR1-mediated STAT3 activation. In summary, our study indicates that in NSCLC, ROR1 could be one of the critical molecular targets mediating DHA-induced STAT3 retardation.
    Journal
    |
    ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • STAT3 (Signal Transducer And Activator Of Transcription 3)
    |
    ROR1 expression • ROR1 overexpression
    5ms
    IL15 (N-803) and IL21 (oHSV-21) Significantly Enhance ROR1 CAR NK Cells Against Pediatric Neuroblastoma (TCT-ASTCT-CIBMTR 2024)
    The N-803 combined with dinutuximab and exPBNK cells significantly extended the survival of NB xenografts (Chu/Cairo, et al, JITC...C021 was generated by modifying C134 to express human IL21 gene... Our data demonstrated IL15 or IL21 based novel cytokine therapy (N-803 or C021) significantly enhanced the anti-tumor efficacy of ROR1 CAR NK targeting NB in vitro and in vivo
    Clinical
    |
    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • IFNG (Interferon, gamma) • ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • GZMB (Granzyme B) • GZMA (Granzyme A) • IL15 (Interleukin 15) • IL21 (Interleukin 21)
    |
    MYCN amplification • ROR1 expression • ROR1 overexpression
    |
    Anktiva (nogapendekin alfa inbakicept-pmln) • Unituxin (dinutuximab)