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    GENE:

    RNPEP (Arginyl Aminopeptidase)

    i
    Other names: Arginyl Aminopeptidase, Aminopeptidase B, APB, Arginine Aminopeptidase, AP-B, Arginyl Aminopeptidase (Aminopeptidase B), RNPEP
    1year
    Tumor exosomal RNPEP promotes lung metastasis of liver cancer via inducing cancer-associated fibroblast activation. (PubMed, Cancer Sci)
    Furthermore, tumor-derived exosomal RNPEP induced the activation of NF-κB signaling in MRC-5 cells, a critical pathway associated with CAF activation. Collectively, these results provide novel insight into tumor-derived exosomal RNPEP for its crosstalk with CAFs during HCC lung metastasis.
    Journal
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    RNPEP (Arginyl Aminopeptidase)
    over4years
    Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells. (PubMed, Hemasphere)
    Melflufen, a substrate of aminopeptidase B, efficiently eliminates bortezomib-resistant myeloma cells in vitro and in vivo, and completely suppresses clonogenic myeloma growth in vitro at subphysiological concentrations. Thus, melflufen represents a novel treatment option that is able to eradicate drug-resistant myeloma clones characterized by elevated aminopeptidase B expression.
    Journal
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    RNPEP (Arginyl Aminopeptidase)
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    bortezomib • Melflufen (melphalan flufenamide)