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    GENE:

    RNF31 (Ring Finger Protein 31)

    i
    Other names: RNF31, Ring Finger Protein 31, ZIBRA, HOIP, HOIL-1-Interacting Protein, Paul, Zinc In-Between-RING-Finger Ubiquitin-Associated Domain Protein, RING-Type E3 Ubiquitin Transferase RNF31, E3 Ubiquitin-Protein Ligase RNF31, FLJ10111, FLJ23501, RING Finger Protein 31
    4ms
    Activating transcription factor 4-mediated upregulation of Heat Shock Protein Family A Member 4 promotes hepatocellular carcinoma progression through activation of Wnt/β-catenin/EMT signaling pathway. (PubMed, Int J Biol Macromol)
    Knockdown of ATF4 reduced HSPA4 levels and suppressed HCC progression. These findings suggest that HSPA4, regulated by ATF4, may serve as a promising therapeutic target and prognostic biomarker for HCC.
    Journal • IO biomarker
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    FLT3 (Fms-related tyrosine kinase 3) • BCL2 (B-cell CLL/lymphoma 2) • ATRX (ATRX Chromatin Remodeler) • SQSTM1 (Sequestosome 1) • DNMT1 (DNA methyltransferase 1) • ATF4 (Activating Transcription Factor 4) • GATA3 (GATA binding protein 3) • RNF31 (Ring Finger Protein 31) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • MAPK8 (Mitogen-activated protein kinase 8) • TCF4 (Transcription Factor 4) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    1year
    KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31. (PubMed, Dev Cell)
    Notably, knockin of USP25C178A in KRasG12D-driven NSCLC models fails to inhibit cancer progression and reconstitution of USP25C178A into USP25 KO A549 cells restores tumor growth. These findings identify previously uncharacterized roles of USP25 and RNF31 in oncogenic KRAS-driven NSCLC progression and provide potential therapeutic targets for KRASmuts-related cancers.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • RNF31 (Ring Finger Protein 31) • USP25 (Ubiquitin Specific Peptidase 25)
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    KRAS mutation • KRAS G12D • KRAS G12
    1year
    RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic-nuclear shuttling in human triple-negative breast cancer. (PubMed, Clin Transl Med)
    RNF31 facilitated ALYREF-mediated PTX resistance in TNBC. RNF31 promoted ALYREF nuclear transport via IPO13 in response to PTX treatment, subsequently enhancing the export of mRNAs encoding PTX resistance-related factors, including TUBB3, STMN1, and TAU. Blocking RNF31 trapped ALYREF in the cytoplasm and induced TNBC cell death upon PTX treatment. Inhibiting RNF31 activity re-sensitized PTX-resistant TNBC to PTX treatment.
    Journal
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    TUBB3 (Tubulin beta 3 class III) • MAPT (Microtubule Associated Protein Tau) • RNF31 (Ring Finger Protein 31) • ALYREF (Aly/REF Export Factor) • STMN1 (Stathmin 1)
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    paclitaxel
    over1year
    Lipopolysaccharide-regulated RNF31/NRF2 axis in colonic epithelial cells mediates homeostasis of the intestinal barrier in ulcerative colitis. (PubMed, Cell Signal)
    Overall, depletion of RNF31 effectively relieves DSS-induced colitis in mice by inhibiting NRF2 degradation, suggesting that RNF31 may be a potential therapy for human ulcerative colitis.
    Journal
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    IL18 (Interleukin 18) • IL1B (Interleukin 1, beta) • RNF31 (Ring Finger Protein 31)
    over1year
    High TNF and NF-ĸB pathway dependency are associated with AZD5582 sensitivity in OSCC via CASP8-dependent apoptosis. (PubMed, Cancer Res Commun)
    CASP8-dependent apoptotic and CASP8-independent necroptotic cellular programs mediate AZD5582-induced cell death. In summary, through the systematic integration of pharmacological and CRISPR data, we identified a subset of OSCC with potent sensitivity to AZD5582 mediated through the NF-κB and TNF signalling pathways.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CASP8 (Caspase 8) • RNF31 (Ring Finger Protein 31) • MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7)
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    AZD5582
    almost2years
    RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes. (PubMed, Free Radic Biol Med)
    The findings highlight RNF31's essential role in the regulation of mitochondrial homeostasis in hepatocytes, emphasizing its potential as a therapeutic target for NAFLD.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • RNF31 (Ring Finger Protein 31)
    2years
    RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation. (PubMed, Sci Rep)
    Treatment with HOIPIN-8, a specific LUBAC inhibitor that suppresses RNF31 ubiquitin ligase (E3) activity, showed similar effects, resulting in decreased cell proliferation and invasion. Our clinical and in vitro data showed that RNF31 is a prognostic factor for HCC that promotes tumor aggressiveness via NF-κB activation.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • RNF31 (Ring Finger Protein 31)
    2years
    Predicting Prognosis and Immunotherapy Response in Multiple Cancers Based on the Association of PANoptosis-Related Genes with Tumor Heterogeneity. (PubMed, Genes (Basel))
    Finally, we predicted the possible drugs for targeted therapy of the cancers. These data greatly enhance our understanding of the components of cancer and may lead to the discovery of new biomarkers for predicting immunotherapy response and improving the prognosis of cancer patients.
    Journal • IO biomarker
    |
    TNFAIP3 (TNF Alpha Induced Protein 3) • FADD (Fas associated via death domain) • CASP8 (Caspase 8) • NLRC5 (NLR Family CARD Domain Containing 5) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • CASP6 (Caspase 6, apoptosis-related cysteine peptidase) • NLRP3 (NLR Family Pyrin Domain Containing 3) • RNF31 (Ring Finger Protein 31) • MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7) • PYCARD (PYD And CARD Domain Containing)
    over2years
    Resonance assignments of the PUB domain of the RNF31 protein. (PubMed, Biomol NMR Assign)
    Here, we report the backbone and side-chain resonance assignments of the PUB domain of RNF31 and study the backbone relaxation of the domain. These studies will contribute to further understanding of the structural and functional relationship of RNF31 protein, which may also be a target for drug research.
    Journal
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    RNF31 (Ring Finger Protein 31) • UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5)
    almost3years
    RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis. (PubMed, Oncogene)
    Most importantly, we found that RNF31 could limit RIPK1 kinase activity and further prevent tumor cell death in a transcription-independent manner, suggesting a crucial role of RIPK1 kinase activity in tumorigenesis. Together, our results demonstrate an essential role of RNF31 and RIPK1 kinase activity in tumorigenesis and imply that RNF31 inhibition could be harnessed to enhance antitumor toxicity during tumor immunotherapy.
    Journal
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) • RNF31 (Ring Finger Protein 31)
    almost3years
    High expression of RNF31 is associated with tumor immune cell infiltration and leads to poor prognosis in liver hepatocellular carcinoma. (PubMed, Sci Rep)
    RNF31 is also associated with immune cell infiltration in LIHC. RNF31 may be a potential target for immunotherapy of LIHC.
    Journal • IO biomarker • Immune cell
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • RNF31 (Ring Finger Protein 31)
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    IFNG expression